Biomarker-directed aptamer panels for diagnosis and differentiation of neuroendocrine tumors [0.03%]
生物标志物导向的用于神经内分泌肿瘤诊断和分类的适配体谱系
Mikkel Breinholt Kjær,Asger Givskov Jørgensen,Søren Fjelstrup et al.
Mikkel Breinholt Kjær et al.
Neuroendocrine tumors (NETs) are rare tumors that may arise in the small intestine (siNET) or pancreas (pNET). The tumors have heterogeneous clinical characteristics, and diagnosis may be challenging. Current non-invasive biomarkers perform...
J Herbert
J Herbert
The human brain is highly sensitive to early adversity, which can have long-term consequences for later mental health. It is also a time of rapid learning of social, motor and other skills, including language. It is proposed that pre-adrena...
Carol Fuzeti Elias,Xingfa Han,David Garcia-Galiano et al.
Carol Fuzeti Elias et al.
Puberty is a critical developmental stage during which individuals acquire the capacity for sexual reproduction. This transition involves a series of complex biological events primarily orchestrated by the activation of the hypothalamo-pitu...
Responses to medical treatment in patients with metastatic unresectable small intestinal neuroendocrine tumors - A single center study of 378 patients [0.03%]
378例不可切除转移性小肠神经内分泌肿瘤患者的治疗反应：单中心研究
Cecilie Slott,Seppo W Langer,Peter Oturai et al.
Cecilie Slott et al.
Small intestinal neuroendocrine tumors (siNET) are rare malignancies, often diagnosed at advanced stages with metastatic spread. While surgery is the only curative treatment, medical therapies, including somatostatin analogues (SSA), peptid...
GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats [0.03%]
胃饥饿素受体激动作用增加血液中葡萄糖含量但推迟胃饥饿素高反应大鼠的进食速度
Philippe Zizzari,Olalla Ramírez-Penas,Véronique Pons et al.
Philippe Zizzari et al.
Severe calorie restriction in mouse models has highlighted the crucial role of the ghrelin system in maintaining glycemia and promoting survival. We hypothesized that if ghrelin acts as a survival signal, enhancing the responsivity of the G...
Relative and normalized iodine concentrations derived from photon counting computed tomography and their correlation with tumor grade and Ki67 in pancreatic neuroendocrine neoplasia: A pilot study [0.03%]
基于光子计数CT的相对和归一化碘浓度与胰腺神经内分泌肿瘤分级及Ki67的相关性：一项试点研究
Marwin-Jonathan Sähn,Simon Waltermann,Jonas Ottemöller et al.
Marwin-Jonathan Sähn et al.
Neuroendocrine neoplasms are a rare and complex tumor entity, among which pancreatic neuroendocrine neoplasms generally display a more aggressive behavior. Despite a notable stage migration towards lower stages at initial diagnosis, the inc...
Response of gonadotropin-releasing hormone neurons from female mice to dynamic-clamp-simulated GABAergic conductances across development and after prenatal androgenization [0.03%]
模拟GABA能传导的动态钳夹技术对雌鼠下丘脑视上核 GnRH 神经元发育及孕酮期雄激素化的影响
Jennifer Jaime,R Anthony DeFazio,Suzanne M Moenter
Jennifer Jaime
Disrupted gonadotropin-releasing hormone (GnRH) secretion patterns can impair fertility as in polycystic ovary syndrome (PCOS).We used prenatally androgenized (PNA) female mice, which recapitulate neuroendocrine abnormalities observed in PC...
Reproductive stress response in male black molly Poecilia sphenops: Evidence for receptor specific regulation by GABA [0.03%]
伽玛氨基丁酸以受体依赖性方式调节雄性黑玛丽鱼(Poecilia sphenops)的生殖压力反应的证据
Achyutham Hotha,C B Ganesh
Achyutham Hotha
Gamma-aminobutyric acid (GABA) is a primary inhibitory neurotransmitter involved in several physiological functions, including reproduction in vertebrates. However, its role in stress-induced reproductive modulation in viviparous teleosts r...
A new, machine learning-based approach to metastatic neuroendocrine tumors of unknown origin [0.03%]
基于机器学习的未知来源转移性神经内分泌肿瘤的新方法
Jiaxi Lü,Tania Amin,Till Clauditz et al.
Jiaxi Lü et al.
Neuroendocrine tumors (NETs) frequently present at a metastatic stage, particularly with liver metastases. Identifying the site of the primary tumor is critical for guiding therapy but often proves difficult. Small intestine NETs are especi...
Glucocorticoids and cell fate in the developing brain: Neuroendocrine mechanisms shaping developmental trajectories [0.03%]
糖皮质激素与发育性脑细胞命运：重塑神经内分泌机制的发育轨迹
Helen Eachus
Helen Eachus
Early life stress (ELS) is a major risk factor for later psychiatric and neurological disorders. Glucocorticoids (GCs), the hormonal end-products of the neuroendocrine stress response, are central mediators of this risk, influencing how the...