Exosomal miR-221-3p derived from bone marrow mesenchymal stem cells alleviates endoplasmic reticulum stress-mediated apoptosis in nucleus pulposus cells via the Nrf2/HO-1 signalling pathway [0.03%]
骨髓间充质干细胞源外泌体miR-221-3p通过Nrf2/HO-1信号通路缓解细胞内质网应激介导的椎间盘软骨终板细胞凋亡
Gang Xu,Kun Zhu,Zhixiang Chen et al.
Gang Xu et al.
Excessive endoplasmic reticulum (ER) stress can lead to apoptosis of nucleus pulposus cells (NPCs), a hallmark of intervertebral disc degeneration (IVDD). Our study aimed to determine whether bone marrow mesenchymal stem cells (BMSCs-exos) ...
Effect of pulmonary arterial hypertension on the morphology and antioxidant defence of the ventral prostate of sedentary and exercised rats [0.03%]
肺动脉高压对久坐和运动大鼠腹侧前列腺形态及抗氧化防御的影响
Luiz Otávio Guimarães-Ervilha,Thainá Iasbik-Lima,Leôncio Lopes Soares et al.
Luiz Otávio Guimarães-Ervilha et al.
Pulmonary arterial hypertension (PAH) is a chronic disease characterized by increased pulmonary vascular resistance, right ventricular overload and systemic repercussions, including disorders in non-target organs. This study aimed to invest...
Nan Jiang,Beibei Hu,Xin Shu et al.
Nan Jiang et al.
With high morbidity and mortality internationally, oesophageal cancer is one of the most common diseases of the digestive system. The most frequent approaches to the treatment of oesophageal cancer are a combination of chemotherapy and radi...
Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism [0.03%]
猪呼吸道疾病复合体诱导与鞘脂代谢异常相关的肺纤维化
Xiangfang Tang,Gaokai Li,Lijun Shi et al.
Xiangfang Tang et al.
Porcine respiratory disease complex (PRDC) is a common syndrome in the modern swine industry worldwide, and its pathogenesis remains unclear to date. Our study aimed to investigate PRDC-induced pulmonary fibrosis and sphingolipid metabolism...
Molecular epidemiology of Epstein-Barr virus in gastric cancer patients compared to healthy control group in Shiraz, Iran [0.03%]
伊朗设拉子胃癌患者中EB病毒的分子流行病学与健康对照组的对比研究
Fatemeh Hosseini Tabatabaie,Sahel Faraji,Mohammad Ansari et al.
Fatemeh Hosseini Tabatabaie et al.
Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. The Epstein-Barr virus (EBV) may play a role in certain cases of GC. Therefore, this study aimed to investigate the prevalence of EBV in the gastric tissu...
The role of ketone bodies in oxidized LDL-induced cell proliferation and lipid accumulation of macrophages [0.03%]
酮体介导氧化低密度脂蛋白诱导巨噬细胞增殖和脂质蓄积中的作用研究
Akira Sato,Hina Nemoto,Ayano Yabuki et al.
Akira Sato et al.
Ketone bodies (KBs), which include β-hydroxybutyric acid (β-HB) and acetoacetic acid (AcAc), play critical roles in organismal energy homeostasis; however, their effects on atherosclerosis remain unknown. In this study, we investigated th...
Role of the tendon circadian clock in tendinopathy and implications for therapeutics [0.03%]
肌腱昼夜钟在肌腱病中的作用及治疗意义
Ask Møbjerg,Sara Dietz Pedersen,Michael Kjaer et al.
Ask Møbjerg et al.
Tendinopathy or tendon overuse injury is a major clinical problem for individuals and has a significant socio-economic cost. Its pathophysiology is not yet fully understood and involves multiple factors, including mechanical, cellular and m...
Exercise combined with corticoid/omega-3 therapy positively affected skeletal and cardiac muscles in middle aged mdx mice [0.03%]
锻炼联合皮质类固醇/ω-3疗法可改善中间年龄段mdx小鼠的骨骼肌和心脏肌肉的功能
Paula Andrea Saenz Suarez,Marcos Maciel Junior,Samara Camaçari de Carvalho et al.
Paula Andrea Saenz Suarez et al.
Exercise has an important impact on skeletal muscle quality, emerging as an adjuvant therapy to ameliorate muscle inflammation and fibrosis in Duchenne muscular dystrophy (DMD). The aim of the present study was to investigate the benefit of...
Extracellular matrix: Dystroglycan interactions-Roles for the dystrophin-associated glycoprotein complex in skeletal tissue dynamics [0.03%]
细胞外基质：dysdaglycan相互作用-与骨骼组织动力学中的dysdaglycan相关糖蛋白复合物的作用
Mark Hopkinson,Andrew A Pitsillides
Mark Hopkinson
Contributions made by the dystrophin-associated glycoprotein complex (DGC) to cell-cell and cell-extracellular matrix (ECM) interactions are vital in development, homeostasis and pathobiology. This review explores how DGC functions may exte...