Early programming and late-acting checkpoints governing the development of CD4 T-cell memory [0.03%]
控制CD4T细胞记忆发育的早期编程和晚期作用检查点
Kunal Dhume,Karl Kai McKinstry
Kunal Dhume
CD4 T cells contribute to protection against pathogens through numerous mechanisms. Incorporating the goal of memory CD4 T-cell generation into vaccine strategies therefore offers a powerful approach to improve their efficacy, especially in...
Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus [0.03%]
圆形单链RNA表达谱及hsa_circ_0045272在系统性红斑狼疮中的潜在功能
Lian-Ju Li,Zhi-Wei Zhu,Wei Zhao et al.
Lian-Ju Li et al.
Circular RNAs (circRNAs) represent a class of non-coding RNAs that form covalently closed RNA circles with extensive expression and conservation in mammals. Circular RNAs regulate gene expression through acting as competitive endogenous RNA...
Tomasz Ahrends,Jannie Borst
Tomasz Ahrends
Cancer immunotherapy focuses mainly on anti-tumour activity of CD8+ cytotoxic T lymphocytes (CTLs). CTLs can directly kill all tumour cell types, provided they carry recognizable antigens. However, CD4+ T cells also play important roles in ...
Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome [0.03%]
免疫营养与炎症性肠病：通过调节饮食和肠道菌群的新型治疗途径
Larissa S Celiberto,Franziska A Graef,Genelle R Healey et al.
Larissa S Celiberto et al.
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, thought to at least in part reflect an aberrant immune response to gut bacteria. IBD is increasing in incidence, particularly in populations...
The role of transforming growth factor β in T helper 17 differentiation [0.03%]
转化生长因子β在T辅助细胞17分化中的作用
Song Zhang
Song Zhang
T helper 17 (Th17) cells play critical roles in inflammatory and autoimmune diseases. The lineage-specific transcription factor RORγt is the key regulator for Th17 cell fate commitment. A substantial number of studies have established the ...
Thomas Scambler,Jonathan Holbrook,Sinisa Savic et al.
Thomas Scambler et al.
Ascertaining the dominant cell type driving an immunological disease is essential to understanding the causal pathology and, therefore, selecting or developing an effective treatment. Classifying immunological diseases in this way has led t...
Daniel M Altmann
Daniel M Altmann
Editorial
Immunology. 2018 May;154(1):1-2. DOI:10.1111/imm.12932 2018
Mapping the tumour human leukocyte antigen (HLA) ligandome by mass spectrometry [0.03%]
基于质谱的肿瘤人类白细胞抗原(HLA)配体组测绘技术
Lena Katharina Freudenmann,Ana Marcu,Stefan Stevanović
Lena Katharina Freudenmann
The entirety of human leukocyte antigen (HLA)-presented peptides is referred to as the HLA ligandome of a cell or tissue, in tumours often termed immunopeptidome. Mapping the tumour immunopeptidome by mass spectrometry (MS) comprehensively ...
A humanized TCR retaining authentic specificity and affinity conferred potent anti-tumour cytotoxicity [0.03%]
一种具有真实特异性和亲和力的人源化TCR能够有效杀死肿瘤细胞
Lin Chen,Ye Tian,Kai Zhan et al.
Lin Chen et al.
The affinity of T-cell receptor (TCR) determines the efficacy of TCR-based immunotherapy. By using human leucocyte antigen (HLA)-A*02 transgenic mice, a TCR was generated previously specific for human tumour testis antigen peptide MAGE-A311...
Impacts of microbiome metabolites on immune regulation and autoimmunity [0.03%]
微生物代谢产物对免疫调节和自身免疫的影响
Stefanie Haase,Aiden Haghikia,Nicola Wilck et al.
Stefanie Haase et al.
A vast number of studies have demonstrated a remarkable role for the gut microbiota and their metabolites in the pathogenesis of inflammatory diseases, including multiple sclerosis (MS). Recent studies in experimental autoimmune encephalomy...