CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action [0.03%]
CD6单克隆抗体在表位、动力学和作用机制上有所不同
Lee I Garner,Andrew Hartland,Johannes Breuning et al.
Lee I Garner et al.
CD6 is a type I T-cell surface receptor that modulates antigen receptor signalling. Its activity is regulated by binding of its membrane proximal domain (domain 3) to a cell surface ligand, CD166. CD6 monoclonal antibodies (mAbs) specific f...
Muzamil Y Want,Amit A Lugade,Sebastiano Battaglia et al.
Muzamil Y Want et al.
Major progress in the analysis of human immune responses to cancer has been made through the molecular characterization of human tumour antigens. The development of therapeutic strategies for eliciting immune-mediated rejection of tumours h...
Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity [0.03%]
分段丝状细菌诱导的免疫反应：宿主保护和自身免疫之间的平衡行为
Kyle L Flannigan,Timothy L Denning
Kyle L Flannigan
Segmented filamentous bacteria (SFB) are Gram-positive, spore-forming, bacteria that primarily colonize the ileum of the small intestine. Upon direct adherence to intestinal epithelial cells, SFB actively stimulate innate and adaptive immun...
Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer [0.03%]
结直肠癌中肿瘤YAP1和PTEN表达与肿瘤相关髓系抑制细胞的扩增及生存期下降相关
Rong Yang,Ting-Ting Cai,Xiao-Jun Wu et al.
Rong Yang et al.
The expansion of myeloid-derived suppressor cells (MDSCs) correlates with tumorigenesis in colorectal cancer (CRC). Here, we found a significant association between CD33+ MDSC number and Yes-associated protein 1 (YAP1) and phosphatase and t...
Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of Sjögren syndrome [0.03%]
非肥胖糖尿病小鼠模型中特异性影响雌性的唾液腺炎源于保护唾液腺的调节性T细胞功能障碍
Jennifer Y Barr,Xiaofang Wang,Portia A Kreiger et al.
Jennifer Y Barr et al.
Immune cell-mediated destruction of salivary glands is a hallmark feature of Sjögren syndrome. Similar to the female predominance in humans, female non-obese diabetic (NOD) mice develop spontaneous salivary gland autoimmunity. However, in ...
MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis [0.03%]
小鼠多发性硬化动物模型中枢神经系统浸润树突状细胞的微小核糖核酸谱型研究
Mariah L Hoye,Angela S Archambault,Taylor M Gordon et al.
Mariah L Hoye et al.
Innate immune cells are integral to the pathogenesis of several diseases of the central nervous system (CNS), including multiple sclerosis (MS). Dendritic cells (DCs) are potent CD11c+ antigen-presenting cells that are critical regulators o...
Penelope A Morel
Penelope A Morel
Upon encounter with their cognate antigen, naive CD4 T cells become activated and are induced to differentiate into several possible T helper (Th) cell subsets. This differentiation depends on a number of factors including antigen-presentin...
Interleukin-23 promotes intestinal T helper type17 immunity and ameliorates obesity-associated metabolic syndrome in a murine high-fat diet model [0.03%]
白细胞介素-23促进小鼠高脂饮食模型肠道T辅助细胞17免疫并缓解肥胖相关代谢综合征
Larissa M S Martins,Malena M Perez,Camila A Pereira et al.
Larissa M S Martins et al.
We addressed the role of interleukin-23 (IL-23) in driving the intestinal T helper type 17 (Th17) response during obesity and metabolic syndrome progression induced by a high-fat diet (HFD). Diet-induced obese and lean mice received HFD or ...
End-stage renal disease, dialysis, kidney transplantation and their impact on CD4+ T-cell differentiation [0.03%]
终末期肾病、透析、肾移植及其对CD4+t细胞分化的影响
Matthias Schaier,Angele Leick,Lorenz Uhlmann et al.
Matthias Schaier et al.
Premature aging of both CD4+ regulatory T (Treg) and CD4+ responder-T (Tresp) cells in patients with end-stage renal disease (ESRD) is expected to affect the success of later kidney transplantation. Both T-cell populations are released from...
Damien Chaussabel,Darawan Rinchai
Damien Chaussabel
Systems-scale molecular profiling data accumulating in public repositories may constitute a useful resource for immunologists. It is for instance likely that information relevant to their chosen line of research be found among the more than...