Julian R Marchesi
Julian R Marchesi
CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis [0.03%]
CD93在自身免疫性脑脊髓炎两种小鼠模型中的中枢神经系统炎症调节作用
Mark R Griffiths,Marina Botto,Bryan Paul Morgan et al.
Mark R Griffiths et al.
Microglia and non-professional immune cells (endothelial cells, neurons) participate in the recognition and removal of pathogens and tissue debris in the injured central nervous system through major pro-inflammatory processes. However, the ...
Ismail Sebina,Ashraful Haque
Ismail Sebina
Type I interferons (IFNs) are a family of cytokines with a wide range of biological activities including anti-viral and immune-regulatory functions. Here, we focus on the protozoan parasitic disease malaria, and examine the effects of type ...
A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens [0.03%]
复杂的细胞外基质与固有免疫系统对抗微生物病原体的相互作用
Hannah Tomlin,Anna M Piccinini
Hannah Tomlin
The role of the host extracellular matrix (ECM) in infection tends to be neglected. However, the complex interactions between invading pathogens, host tissues and immune cells occur in the context of the ECM. On the pathogen side, a variety...
New tools for MHC research from machine learning and predictive algorithms to the tumour immunopeptidome [0.03%]
机器学习和预测算法在MHC研究中的新工具——从免疫肽组学到肿瘤免疫肽组学
Daniel M Altmann
Daniel M Altmann
At a time when immunology seeks to progress ever more rapidly from characterization of a microbial or tumour antigen to the immune correlates that may define protective T-cell immunity, there is a need for robust tools to enable accurate pr...
Editorial
Immunology. 2018 Jul;154(3):329-330. DOI:10.1111/imm.12956 2018
The interaction between invariant Natural Killer T cells and the mucosal microbiota [0.03%]
不变自然杀伤T细胞与黏膜微生物群的相互作用
Fatma Zehra Hapil,Gerhard Wingender
Fatma Zehra Hapil
The surface of mammalian bodies is colonized by a multitude of microbial organisms, which under normal conditions support the host and are considered beneficial commensals. This requires, however, that the composition of the commensal micro...
Neuroimmunology and neuroinflammation in autoimmune, neurodegenerative and psychiatric disease [0.03%]
自身免疫、神经退行性和精神疾病中的神经免疫学和神经炎症
Daniel M Altmann
Daniel M Altmann
An ever-increasing collection of neurological human diseases are becoming appreciated as encompassing a strong immunological component in pathogenesis or regulation. This derives to a large extent from genome-wide association studies that h...
Editorial
Immunology. 2018 Jun;154(2):167-168. DOI:10.1111/imm.12943 2018
Toll-like receptor 4 signalling regulates antibody response to adenoviral vector-based vaccines by imprinting germinal centre quality [0.03%]
toll-like受体4信号通过编程生发中心质量调节腺病毒载体疫苗的抗体应答
Ruihua Li,Ju Liu,Shipo Wu et al.
Ruihua Li et al.
Adenoviral vectors (AdV) are considered promising candidates for vaccine applications. A prominent group of Toll-like receptors (TLRs) participate in the adenovirus-induced adaptive immune response, yet there is little information regarding...
ImmTAC/Anti-PD-1 antibody combination to enhance killing of cancer cells by reversing regulatory T-cell-mediated immunosuppression [0.03%]
ImmTAC和抗PD-1抗体联合用药通过逆转调节性T细胞介导的免疫抑制来增强对癌细胞的杀伤作用
Huanling Zhang,Yanyan Li,Xiaoping Liu et al.
Huanling Zhang et al.
Recently, bi-functional molecules that can redirect immune effectors to tumour cells have emerged as potentially robust mediators of tumour regression in clinical trials. Two modalities in particular, bi-specific antibodies for T-cell redir...
Andrew J McDermott,Bruce S Klein
Andrew J McDermott
The mucosal surface of the respiratory tract encounters microbes, such as fungal particles, with every inhaled breath. When pathogenic fungi breach the physical barrier and innate immune system within the lung to establish an infection, ada...