T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection [0.03%]
抗逆转录病毒治疗对感染了猴免疫缺陷病毒的T细胞亚群分化和抗体反应的影响
Mitra Bhattacharyya,James B Whitney,Michael Seaman et al.
Mitra Bhattacharyya et al.
Antiretroviral therapy (ART) for the treatment of human immunodeficiency virus (HIV) infection represents a major breakthrough in the treatment of HIV/acquired immune-deficiency syndrome. However, it remains unclear how ART influences virus...
Sandeep K Dhanda,Kerrie Vaughan,Veronique Schulten et al.
Sandeep K Dhanda et al.
Epitopes identified in large-scale screens of overlapping peptides often share significant levels of sequence identity, complicating the analysis of epitope-related data. Clustering algorithms are often used to facilitate these analyses, bu...
Regulatory T cells control epitope spreading in autoimmune arthritis independent of cytotoxic T-lymphocyte antigen-4 [0.03%]
调节性T细胞独立于细胞毒性T淋巴细胞抗原-4控制自身免疫性关节炎中的抗原播散
Min Yang,Katrin Klocke,Clara Marquina Hernandez et al.
Min Yang et al.
CD4+ Foxp3+ regulatory T (Treg) cells can control both cellular and humoral immune responses; however, when and how Treg cells play a predominant role in regulating autoimmune disease remains elusive. To deplete Treg cells in vivo at given ...
Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis [0.03%]
一项研究pH值转换型抗C5抗体的研究：将该抗体作为人类和小鼠补体C5纯化及跨物种经典反应溶细胞作用抑制剂的实验工具
Wioleta M Zelek,Matthew Stott,David Walters et al.
Wioleta M Zelek et al.
C5 plays a major role in complement activation; C5 convertase cleaves C5 into the pro-inflammatory C5a, and C5b, the nidus for the formation of the lytic membrane attack complex. C5 is a major target for anti-complement drugs, necessitating...
Low-molecular-mass hyaluronan induces pulmonary inflammation by up-regulation of Mcl-1 to inhibit neutrophil apoptosis via PI3K/Akt1 pathway [0.03%]
低分子量透明质酸通过PI3K/Akt1信号上调Mcl-1诱导肺部炎症的新机制研究
Hang Zhao,Yating Ma,Leifang Zhang
Hang Zhao
Although low-molecular-mass hyaluronan (LMMHA) has been implicated in pulmonary inflammatory diseases, the signalling pathway of LMMHA (200 000 molecular weight) that initiates the inflammatory response in lung is still unknown. In this stu...
Interleukin-6 signalling mediates Galectin-8 co-stimulatory activity of antigen-specific CD4 T-cell response [0.03%]
半乳糖凝集素8通过介导白细胞介素6信号转导共刺激抗原特异性CD4+T细胞活化
Julieta Carabelli,Cecilia A Prato,Liliana M Sanmarco et al.
Julieta Carabelli et al.
Galectin-8 (Gal-8) is a mammalian lectin endowed with the ability to co-stimulate antigen-specific immune responses. We have previously demonstrated that bone-marrow-derived dendritic cells produce high levels of interleukin-6 (IL-6) in res...
Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection [0.03%]
人自然感染克鲁氏锥虫细胞液中隐翅红糠孢子菌过氧化物酶的免疫反应评估
Magalí C Girard,Gonzalo R Acevedo,Lucía López et al.
Magalí C Girard et al.
Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by its host. One of the antioxidant enzymes involved is the cytosolic tryparedoxin peroxidase...
Clinical Trial
Immunology. 2018 Nov;155(3):367-378. DOI:10.1111/imm.12979 2018
Felix Clemens Richter,Sandrine Obba,Anna Katharina Simon
Felix Clemens Richter
Immune cell differentiation and function depend on metabolic changes for the provision of energy and metabolites. Consequently, cellular metabolism relies on the availability of micronutrients such as vitamins and energy-rich sources includ...
Peyer's patches-derived CD11b+ B cells recruit regulatory T cells through CXCL9 in dextran sulphate sodium-induced colitis [0.03%]
派氏垫特化CD11b+B细胞通过CXCL9募集调节性T细胞以治疗硫酸盐钠诱导的结肠炎
Zhiming Wang,Hushan Zhang,Ronghua Liu et al.
Zhiming Wang et al.
Regulatory T (Treg) cells play an essential role in the maintenance of intestinal homeostasis. In Peyer's patches (PPs), which comprise the most important IgA induction site in the gut-associated lymphoid tissue, Treg cells promote IgA isot...
Macrophage targeting: opening new possibilities for cancer immunotherapy [0.03%]
巨噬细胞靶向：为癌症免疫治疗开辟新的可能性
Luca Cassetta,Takanori Kitamura
Luca Cassetta
Tumour-infiltrating immune cells regulate tumour development and progression either negatively or positively. For example, cytotoxic lymphocytes (CTL) such as CD8+ T and natural killer (NK) cells can recognize and eliminate cancer cells, an...