γδ T cells modulate humoral immunity against Plasmodium berghei infection [0.03%]
γδT细胞通过调节疟疾血症时期B1b淋巴细胞增殖来调控体液免疫应答
Shin-Ichi Inoue,Mamoru Niikura,Hiroko Asahi et al.
Shin-Ichi Inoue et al.
It is unclear whether γδ T cells are involved in humoral immunity against Plasmodium infection. Here, we show that B-cell-immunodeficient mice and γδ T-cell-deficient mice were incapable of protecting against Plasmodium berghei XAT para...
Santosh Kumar,Shweta Jain
Santosh Kumar
Formation of supramolecular assemblies appears to be a general mechanism in immune signalling pathways. These supramolecular assemblies appear to form through a nucleated polymerization mechanism. This review examines selected immune signal...
Interleukin-17-producing γδ T (γδ17) cells in inflammatory diseases [0.03%]
炎症性疾病中的产生白细胞介素-17的γδT（γδ17）细胞
Aoi Akitsu,Yoichiro Iwakura
Aoi Akitsu
Interleukin-17 (IL-17) is a pro-inflammatory cytokine and is involved in the development of many diseases. Recent studies have revealed that IL-17-producing γδ T cells (γδ17 cells) in addition to IL-17-producing CD4+ T cells [T helper t...
MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease [0.03%]
自身免疫病中microRNA介导的T辅助细胞17/调节性T细胞平衡的调控
Cuilian Liu,Haoran Yang,Weiyun Shi et al.
Cuilian Liu et al.
T helper type 17 (Th17) cells and regulatory T (Treg) cells are two distinct T-cell subsets with opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of ...
Human CD8 T-cell activation in acute and chronic chikungunya infection [0.03%]
急性期和慢性期白脉病的CD8T细胞活化作用
Cinthia Nóbrega de Sousa Dias,Bruna Macêdo Gois,Viviane Silva Lima et al.
Cinthia Nóbrega de Sousa Dias et al.
There is a need for more detailed elucidation of T-cell immunity in chikungunya infection. CD8 T cells are one of main actors against viruses. Here, we analysed CD8+ T lymphocytes from patients in the acute and chronic phases of chikungunya...
YY1 binds to the E3' enhancer and inhibits the expression of the immunoglobulin κ gene via epigenetic modifications [0.03%]
YY1通过表观遗传修饰与Igκ基因的E3'增强子结合并抑制其表达
Xiaorong Zhou,Weiwei Xian,Jie Zhang et al.
Xiaorong Zhou et al.
The rearrangement and expression of immunoglobulin genes are regulated by enhancers and their binding transcriptional factors that activate or suppress the activities of the enhancers. The immunoglobulin κ (Igκ) gene locus has three impor...
Interleukin-33 contributes to disease severity in Dengue virus infection in mice [0.03%]
白细胞介素-33促进小鼠登革病毒感染的致病性
Rafael E Marques,Anne-Gaëlle Besnard,Isabelle Maillet et al.
Rafael E Marques et al.
The excessive inflammation often present in patients with severe dengue infection is considered both a hallmark of disease and a target for potential treatments. Interleukin-33 (IL-33) is a pleiotropic cytokine with pro-inflammatory effects...
The impact of inflationary cytomegalovirus-specific memory T cells on anti-tumour immune responses in patients with cancer [0.03%]
癌患者中通胀性巨细胞病毒特异性记忆T细胞对抗肿瘤免疫反应的影响
Xiao-Hua Luo,Qingda Meng,Martin Rao et al.
Xiao-Hua Luo et al.
Human cytomegalovirus (CMV) is a ubiquitous, persistent beta herpesvirus. CMV infection contributes to the accumulation of functional antigen-specific CD8+ T-cell pools with an effector-memory phenotype and enrichment of these immune cells ...
Pablo Palazon-Riquelme,Gloria Lopez-Castejon
Pablo Palazon-Riquelme
As a result of its strategic location, the epithelium is constantly exposed to a wide variety of pathogen and danger signals. Traditionally, the epithelium has been perceived as a defensive but passive barrier; however, it has now become ev...
Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii [0.03%]
自然杀伤细胞在念珠状假皮酵母菌全身感染后的体内保护中起关键作用
Lucas Souza Ferreira,Deivys Leandro Portuondo,Marisa Campos Polesi et al.
Lucas Souza Ferreira et al.
Natural killer (NK) cells are one of the first cell types to enter inflammation sites and have been historically known as key effector cells against tumours and viruses; now, accumulating evidence shows that NK cells are also capable of dir...