Lucia Russo,Carey N Lumeng
Lucia Russo
The expansion of adipose tissue (AT) in obesity is accompanied by the accumulation of immune cells that contribute to a state of low-grade, chronic inflammation and dysregulated metabolism. Adipose tissue macrophages (ATMs) represent the mo...
Daniel M Altmann
Daniel M Altmann
In the 20-or-so years that immunologists have spent describing the mechanisms and functions of regulatory T-cells, a very great deal has been learnt: a T-cell subset once described for the generic ability to harness autoimmunity in vivo or ...
Editorial
Immunology. 2018 Oct;155(2):153-154. DOI:10.1111/imm.12999 2018
Impact of sex hormones on immune function and multiple sclerosis development [0.03%]
性激素对免疫功能及多发性硬化发病的影响
María C Ysrraelit,Jorge Correale
María C Ysrraelit
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting young people and leading to demyelination and neurodegeneration. The disease is clearly more common in women, in whom incidence has been...
Jinghua Wang,Guoping Wu,Brian Manick et al.
Jinghua Wang et al.
B7 family members and their receptors play a central role in the regulation of T-cell responses through T-cell co-stimulation and co-inhibition pathways that constitute attractive targets for the development of immunotherapeutic drugs. In t...
Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation [0.03%]
全白细胞受体复合物基因组区域的筛选发现了可能是由基因调控解释的天疱疮相关性
Ticiana Della Justina Farias,Danillo G Augusto,Rodrigo Coutinho de Almeida et al.
Ticiana Della Justina Farias et al.
Pemphigus foliaceus (PF) is a blistering autoimmune skin disease rare in most of the world but endemic in certain regions of Brazil. PF is characterized by the detachment of epidermal cells and the presence of autoantibodies against desmogl...
The essential role of complement in antibody-mediated resistance to Salmonella [0.03%]
补体在抗体介导的抗沙门氏菌感染免疫应答中的作用
Omar Rossi,Chris Coward,Yun Shan Goh et al.
Omar Rossi et al.
Vaccines can serve as essential tools to prevent bacterial diseases via the induction of long-lasting IgG responses. The efficacy of such vaccines depends on the effector mechanisms triggered by IgG. The complement system and Fc-gamma recep...
Daniel M Altmann
Daniel M Altmann
Immunology was once a specialty prone to cause dismay or even scepticism among outsiders for its struggles to visualize poorly understood, complex interactions through descriptive models integrating cell types, their factors and functions. ...
Editorial
Immunology. 2018 Sep;155(1):1-2. DOI:10.1111/imm.12987 2018
Corrigendum [0.03%]
勘误表
Published Erratum
Immunology. 2018 Sep;155(1):150-151. DOI:10.1111/imm.12955 2018
Deceleration of glycometabolism impedes IgG-producing B-cell-mediated tumor elimination by targeting SATB1 [0.03%]
糖代谢减缓通过靶向SATB1抑制IgG产生B细胞介导的肿瘤消除
Jiajing Liu,Yifan Li,Zhou Lu et al.
Jiajing Liu et al.
B lymphocytes, known as antibody producers, mediate tumor cell destruction in the manner of antibody-dependent cell-mediated cytotoxicity; however, their anti-tumor function seems to be weakened during tumorigenesis, while the underlying me...
mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity [0.03%]
B细胞中mTORC1激活通过过度活化半胱天冬酶损害边缘区微环境
Naresh Kumar Meena,Shakti Prasad Pattanayak,Yael Ben-Nun et al.
Naresh Kumar Meena et al.
Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and lymphocyte proliferation. It is inhibited by the tuberous sclerosis complex (TSC), a heterodimer of TSC1 and TSC2. Deletion of either gene results in...