Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer [0.03%]
醛脱氢酶在调节性T细胞发育、免疫和癌症中的作用
Christopher G Bazewicz,Saketh S Dinavahi,Todd D Schell et al.
Christopher G Bazewicz et al.
The role of aldehyde dehydrogenase (ALDH) in carcinogenesis and resistance to cancer therapies is well known. Mounting evidence also suggests a potentially important role for ALDH in the induction and function of regulatory T (Treg) cells. ...
Dennis Montoya,Manali Mehta,Benjamin G Ferguson et al.
Dennis Montoya et al.
Macrophage (MΦ) polarization is triggered during the innate immune response to defend against microbial pathogens, but can also contribute to disease pathogenesis. In a previous study, we found that interleukin-15 (IL-15) -derived classica...
A Nobel Prize-worthy pursuit: cancer immunology and harnessing immunity to tumour neoantigens [0.03%]
堪获诺贝尔奖的追求：癌症免疫学与利用免疫力对抗肿瘤新抗原
Daniel M Altmann
Daniel M Altmann
The field of cancer immunology stepped into the limelight this year when James P. Allison and Tasuku Honjo received the Nobel Prize in Physiology or Medicine for their discovery of cancer therapy by inhibition of negative immune regulation....
Editorial
Immunology. 2018 Nov;155(3):283-284. DOI:10.1111/imm.13008 2018
Drebrin 1 in dendritic cells regulates phagocytosis and cell surface receptor expression through recycling for efficient antigen presentation [0.03%]
dendritic细胞中的Drebrin 1通过回收作用调节胞吞作用和细胞表面受体表达以实现高效的抗原呈递
Diana M Elizondo,Temesgen E Andargie,Naomi L Haddock et al.
Diana M Elizondo et al.
Phagocytosis, macropinocytosis and antigen presentation by dendritic cells (DC) requires reorganization of the actin cytoskeleton. Drebrin (Dbn1) is an actin binding and stabilizing protein with roles in endocytosis, formation of dendrite s...
René H M Raeven,Elly van Riet,Hugo D Meiring et al.
René H M Raeven et al.
Systems vaccinology has proven a fascinating development in the last decade. Where traditionally vaccine development has been dominated by trial and error, systems vaccinology is a tool that provides novel and comprehensive understanding if...
Different phenotypes of non-classical monocytes associated with systemic inflammation, endothelial alteration and hepatic compromise in patients with dengue [0.03%]
登革热患者的全身性炎症、内皮细胞改变和肝功能障碍与非经典单核细胞的不同表型相关
Juan S Naranjo-Gómez,Jorge Andrés Castillo,Mauricio Rojas et al.
Juan S Naranjo-Gómez et al.
Although dengue can progress to severe stages, the exact causes of this phenomenon are unknown; however, the possibility of monocyte participation is acknowledged. It has been suggested that monocyte subsets (classical, intermediate and non...
Addition of the C-terminus of CD6 to a chimeric antigen receptor enhances cytotoxicity and does not compromise expression [0.03%]
向嵌合抗原受体添加CD6C端增强细胞毒性且不影响表达水平
Johannes Breuning,Brian Philip,Marion H Brown
Johannes Breuning
T cells expressing chimeric antigen receptors (CARs) are a promising new cancer immunotherapy that has now reached the clinic. CARs are synthetic receptors that redirect T cells towards a tumour-associated antigen and activate them through ...
DNA prime-protein boost vaccine encoding HLA-A2, HLA-A24 and HLA-DR1 restricted epitopes of CaNA2 against visceral leishmaniasis [0.03%]
一种针对内脏利什曼病的CaNA2 DNA-prime-Protein-boots疫苗，包含HLA-A2、HLA-A24和HLA-DR1限制性表位
Jinlei He,Fan Huang,Jianhui Zhang et al.
Jinlei He et al.
Visceral leishmaniasis is a tropical and neglected disease with an estimated 200 000-400 000 cases and 60 000 deaths worldwide each year. Currently, no clinically valid vaccine is available for this disease. In this study, we formulated DNA...
Naoki Iwanaga,Jay K Kolls
Naoki Iwanaga
Interleukin-17 (IL-17)-producing cells play a critical role in mucosal immunity including the respiratory tract. This review will highlight recent advances in our understanding of these cells in mucosal immunity in the lung as well as their...
Recent advances on the crosstalk between neutrophils and B or T lymphocytes [0.03%]
中性粒细胞与B或T淋巴细胞串扰的最新研究进展
Sara Costa,Dalila Bevilacqua,Marco A Cassatella et al.
Sara Costa et al.
An increasing body of literature supports a role for neutrophils as players in the orchestration of adaptive immunity. During acute and chronic inflammatory conditions, neutrophils rapidly migrate not only to sites of inflammation, but also...