B-cell-specific-peroxisome proliferator-activated receptor γ deficiency augments contact hypersensitivity with impaired regulatory B cells [0.03%]
B细胞特异性过氧化物酶体增殖激活受体γ缺乏通过抑制调节性B细胞增强接触性超敏反应
Jianbing Su,Keng Wang,Xuan Zhou et al.
Jianbing Su et al.
Nuclear receptor peroxisome proliferator-activated receptor γ (PPAR-γ) activation can prevent immunoinflammatory disorders and diabetes. B cells play protective roles during inflammation as well. However, the roles of endogenous PPAR-γ i...
A sequence conserved between CD5 and CD6 binds an FERM domain and exerts a restraint on T-cell activation [0.03%]
CD5和CD6保守的序列结合一个FERM区域并对T细胞活化形成抑制作用
Johannes Breuning,Marion H Brown
Johannes Breuning
CD5 and CD6 are related surface receptors that limit and promote T-cell responses. Co-stimulatory effects of CD6 depend on binding a cell surface ligand, CD166, and recruitment of the intracellular adaptor proteins GADS and SLP-76 by C-term...
Frequency and immunophenotype of IL10-producing regulatory B cells in optic neuritis [0.03%]
视神经炎中产IL10的调节性B细胞频率及表型特征分析
Sara Lundqvist,Signe Modvig,Emilie A Fischer et al.
Sara Lundqvist et al.
Mouse models of multiple sclerosis (MS) have shown the importance of interleukin-10 (IL-10) -producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune dis...
Marc Brillantes,Aimee M Beaulieu
Marc Brillantes
Natural killer (NK) cells are highly specialized cytotoxic lymphocytes that provide protection against pathogens and malignant cells. They develop from common lymphoid progenitors via a multi-stage lineage commitment and differentiation pro...
Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co-morbidity [0.03%]
糖尿病合并肺结核患者单核细胞活化标志物水平升高的现象
Nathella P Kumar,Kadar Moideen,Yukthi Bhootra et al.
Nathella P Kumar et al.
Alteration in the frequency of monocyte subsets is a hallmark of tuberculosis-diabetes co-morbidity (TB-DM). To study this association, we examined the plasma levels of sCD14, sCD163, C-reactive protein (CRP) and soluble tissue factor (sTF)...
Interleukin-1β influences functional regeneration following nerve injury in mice through nuclear factor-κB signaling pathway [0.03%]
白细胞介素-1β通过核因子-κB信号途径影响神经损伤小鼠的功能恢复
Ruoyu Wu,Bi Chen,Xiang Jia et al.
Ruoyu Wu et al.
This study focuses on investigating the role of interleukin-1β (IL-1β) in functional regeneration following nerve injury in mice. A microarray-based mRNA profiling study was used to analyze the expression level of IL-1β in peripheral ner...
Jagged1-expressing adenovirus-infected dendritic cells induce expansion of Foxp3+ regulatory T cells and alleviate T helper type 2-mediated allergic asthma in mice [0.03%]
表达Jagged1的腺病毒感染的树突状细胞诱导Foxp3+调节性T细胞增殖并减轻小鼠Th2介导的过敏性哮喘
Chu-Lun Lin,Huei-Mei Huang,Chia-Ling Hsieh et al.
Chu-Lun Lin et al.
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in directing T-cell responses. Regulatory T (Treg) cells possess an immunosuppressive ability to inhibit effector T-cell responses, and Notch ligand Jagged...
Functions of adipose-resident immune subsets and the impact on metabolic syndrome [0.03%]
脂肪组织驻留免疫亚群的功能及其对代谢综合征的影响
Daniel M Altmann
Daniel M Altmann
There is a growing appreciation of the role in the aetiology of metabolic syndrome that is played by the interplay of diet, microbiota and the interactions of immune cells and adipose cells in visceral adipose tissue. Recent studies have hi...
Editorial
Immunology. 2018 Dec;155(4):405-406. DOI:10.1111/imm.13015 2018
PRBAM: a new tool to analyze the MHC class I and HLA-DR anchor motifs [0.03%]
PRBAM：一个用于分析MHCⅠ类和HLA-DRAA锚定基元的新工具
Anna Mestre-Ferrer,Erika Scholz,Jepi Humet-Alsius et al.
Anna Mestre-Ferrer et al.
Major histocompatibility complex (MHC) genes are highly polymorphic, which makes each MHC molecule different regarding their peptide repertoire, so they can bind and present to T lymphocytes. The increasing importance of immunopeptidomics a...
HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasis [0.03%]
髓系和淋巴细胞中HLA-DR II类表达与内脏利什曼病的遗传危险因素HLA-DRB1的关系研究
Bhawana Singh,Michaela Fakiola,Medhavi Sudarshan et al.
Bhawana Singh et al.
Genetic variation at HLA-DRB1 is a risk factor for visceral leishmaniasis (VL) caused by Leishmania donovani. The single nucleotide polymorphism rs9271252 upstream of the DRB1 gene provides a perfect tag for protective versus risk HLA-DRB1 ...