Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells [0.03%]
naïve CD8 T 细胞的细胞表面CD8水平与功能、表型和转录组的相关性研究
Renu Balyan,Rupali Gund,Amanpreet Singh Chawla et al.
Renu Balyan et al.
We have previously demonstrated co-receptor level-associated functional heterogeneity in apparently homogeneous naive peripheral CD4 T cells, dependent on MHC-mediated tonic signals. Maturation pathways can differ between naive CD4 and naiv...
Nina Sopel,Julia Kölle,Sonja Dumendiak et al.
Nina Sopel et al.
Acid sphingomyelinase (ASM) is one of the enzymes that catalyzes the breakdown of sphingomyelin to ceramide and phosphorylcholine. In this study, we aimed at elucidating the role of ASM in allergic asthma. We used an ovalbumin-induced murin...
Claire E Macdougall,M Paula Longhi
Claire E Macdougall
Healthy white adipose tissue (WAT) participates in regulating systemic metabolism, whereas dysfunctional WAT plays a prominent role in the development of obesity-associated co-morbidities. Tissue-resident immune cells are important for main...
Nital Sumaria,Stefania Martin,Daniel J Pennington
Nital Sumaria
Murine γδ T cells display diverse responses to pathogens and tumours through early provision of pro-inflammatory cytokines such as interleukin-17A (IL-17) and interferon-γ (IFN-γ). Although it is now clear that acquisition of these cyto...
Inflammatory response under zinc deficiency is exacerbated by dysfunction of the T helper type 2 lymphocyte-M2 macrophage pathway [0.03%]
锌缺乏状态下Th2淋巴细胞-M2巨噬细胞通路功能障碍加重炎症反应
Takamasa Kido,Kenji Ishiwata,Machi Suka et al.
Takamasa Kido et al.
Nutritional zinc deficiency leads to immune dysfunction and aggravates inflammation. However, the underlying mechanism remains unknown. In this study, the relationship between macrophage subtypes (M1 and M2) and helper T lymphocytes (Th1 an...
T-cell immunology of the lung: maintaining the balance between host defence and immune pathology [0.03%]
肺的T细胞免疫学：在宿主防御和免疫病理之间的平衡维护中的作用
Daniel M Altmann
Daniel M Altmann
Respiratory immunology poses the dual questions of how to grapple with lung infection as one of the greatest unmet global health needs of our time, while also dealing with the growing challenge posed by chronic diseases of excessive or inap...
Editorial
Immunology. 2019 Jan;156(1):1-2. DOI:10.1111/imm.13029 2019
Camouflage and interception: how pathogens evade detection by intracellular nucleic acid sensors [0.03%]
伪装与拦截：病原体如何逃避细胞内核酸传感器的检测
Leonie Unterholzner,Jessica F Almine
Leonie Unterholzner
Intracellular DNA and RNA sensors play a vital part in the innate immune response to viruses and other intracellular pathogens, causing the secretion of type I interferons, cytokines and chemokines from infected cells. Pathogen RNA can be d...
Basics of memory B-cell responses: lessons from and for the real world [0.03%]
记忆B细胞反应的基本原理：来自和应用于现实世界的教训
Rachel Wong,Deepta Bhattacharya
Rachel Wong
The production of pathogen-specific B cells and antibodies underlies protective immunity elicited by most vaccines and many infections. Humoral immunity follows a regulated process by which high-affinity antibody-secreting plasma cells and ...
Neutrophils mitigate the systemic host response during endotoxemia in mice [0.03%]
中性粒细胞在小鼠内毒素血症期间可缓解全身宿主反应
Anne Jan van der Meer,Chao Ding,Arie Johan Hoogendijk et al.
Anne Jan van der Meer et al.
Recent studies have suggested that neutrophils can exert anti-inflammatory effects. To determine the role of neutrophils in the acute response to lipopolysaccharide (LPS), a component of the Gram-negative bacterial cell wall, we challenged ...
Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model [0.03%]
白细胞介素17/白细胞介素17受体轴募集肠道中性粒细胞，抑制高脂饮食诱导的代谢综合征模型中小肠菌群失调及内毒素移位
Malena M Pérez,Larissa M S Martins,Murilo S Dias et al.
Malena M Pérez et al.
Sound evidence supports a role for interleukin-17 (IL-17) -producing γδ T cells and IL-17-producing helper T (Th17) cells in intestinal homeostasis, especially in intestinal barrier integrity. In the present study, we aimed to evaluate th...