Inhibition of IRE1α Alleviates Renal Fibrosis and Downregulates M1 Macrophage Activation via the p38 MAPK Pathway [0.03%]
抑制IRE1α缓解肾纤维化并下调M1型巨噬细胞活化中的p38丝裂原活化蛋白激酶途径作用机制研究
Zichan Guo,Yuting Shen,Xiaxia Yu et al.
Zichan Guo et al.
The enhanced M1 macrophage activation and proportion significantly promote the progression of renal fibrosis in the unilateral ureteral obstruction (UUO) model, while the underlying mechanisms need to be further studied. Here, we examined w...
BCG Vaccination Reprograms the Function of M-MDSCs and Aggravates Necrotizing Enterocolitis in Neonates [0.03%]
卡介苗接种重塑M-MDSC功能并加重新生儿坏死性小肠结肠炎病情
Yingying Chen,Hui Li,Yongmei Zhang et al.
Yingying Chen et al.
Bacillus Calmette-Guérin (BCG), a live-attenuated vaccine primarily used against tuberculosis (TB), also provides protection against a broad array of antigens or heterologous antigens through the induction of trained immunity (TI). While B...
Application and Perspectives of Immunotherapy in Head and Neck Squamous Cell Carcinoma [0.03%]
免疫治疗在头颈部鳞癌中应用及展望
Zihao Zhang,Xiaohui Meng,Liang Han
Zihao Zhang
Head and neck squamous cell carcinoma poses grave challenges to clinicians and patients due to its tumour invasiveness and treatment uncertainties. Despite the substantial improvements in conventional treatment modalities such as surgery, c...
Review
Immunology. 2025 May 21. DOI:10.1111/imm.13951 2025
Limitation of Deleterious iNOS-Expressing Interstitial Macrophages Is Dependent on Protective IL-1α and IL-17 in Tuberculosis and Existing Obesity [0.03%]
结核病和共生肥胖中IL-1α和IL-17限制有害的间质巨噬细胞的作用
Vinicius Bottura Apolloni,Rômulo Silva de Oliveira,Ualter Guilherme Cipriano et al.
Vinicius Bottura Apolloni et al.
IL-1α, IL-1β, IFN-γ, IL-17 and the expression of inducible nitric oxide synthase (iNOS) enzyme by macrophages, which generate nitric oxide, are protective against tuberculosis, a disease caused by Mycobacterium tuberculosis. The severity...
The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review [0.03%]
SPP1+巨噬细胞在组织和疾病中的景观：全面综述
Alessandro Palma
Alessandro Palma
Macrophages play a critical role in shaping the immune landscape of various diseases, with secreted phosphoprotein 1 (SPP1)-expressing macrophages emerging as a distinct subset implicated in both cancerous and non-cancerous conditions. Leve...
Review
Immunology. 2025 May 21. DOI:10.1111/imm.13952 2025
Antibiotic-Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa [0.03%]
抗生素诱导的小肠细菌移生导致宿主色氨酸代谢改变并增加小鼠感染绿脓杆菌的易感性
Camila Bernardo de Brito,Raquel Duque do Nascimento Arifa,Rafael de Oliveira Bezerra et al.
Camila Bernardo de Brito et al.
Pseudomonas aeruginosa is an opportunistic bacterium that mainly infects those who have previously been treated with antibiotics. We hypothesised that antibiotic treatment disrupts tryptophan metabolism, leading to increased susceptibility ...
Beyond Canonical Immune Checkpoints: Overexpression of TNFRSF Members 4-1BB and OX-40 Marks T Cells Exhibiting Phenotypic Features of Exhaustion in Cervical Carcinoma [0.03%]
超越经典的免疫检查点：宫颈癌中T细胞耗竭的标志是TNFRSF成员（4-1BB和OX-40）过度表达
Jose Manuel Rojas-Diaz,Fabiola Solorzano-Ibarra,Nadia Tatiana Garcia-Barrientos et al.
Jose Manuel Rojas-Diaz et al.
T cells are pivotal in combating cancer; however, they can become exhausted during tumour progression, losing their cytotoxic capacity and upregulating inhibitory receptors including PD-1 and TIGIT. While checkpoint blockade has emerged as ...
CCR5-Mediated Reprogramming of Regulatory T Cells and Monocytic-Myeloid-Derived Suppressor Cells in Young Dyslipidemic Individuals: A Plausible Therapeutic Approach [0.03%]
年轻高脂血症患者中CCR5介导的调节性T细胞和单核类髓源抑制细胞重编程：可能的治疗方法
Komal Sagar,Shamima Akhtar,Nikita Kumar et al.
Komal Sagar et al.
Chemokine receptor CCR5 is upregulated in the regulatory T cells (Tregs) and monocytic-myeloid-derived suppressor cells (M-MDSCs) of young dyslipidemic individuals. In this study, we investigated the role of CCR5 in regulating the phenotypi...
A Review on Biosensors for Quantification of MCP-1 as a Potential Biomarker in Diseases [0.03%]
用于疾病中MCP-1潜在生物标志物定量的生物传感器综述
Zahra Jamalizadeh Bahaabadi,Mohammad Javad Javid-Naderi,Prashant Kesharwani et al.
Zahra Jamalizadeh Bahaabadi et al.
Monocyte chemoattractant protein-1 (MCP-1) as a chemokine is essential for inflammation-related processes. It regulates immunological responses and cell migration, which contribute to inflammation. Many disorders are exacerbated by this che...
Review
Immunology. 2025 May 14. DOI:10.1111/imm.13944 2025
Depressive Disorder Affects TME and Hormonal Changes Promoting Tumour Deterioration Development [0.03%]
抑郁症影响TME和激素变化促进肿瘤恶化发展
Jingjing Dong,Juan Du,Ruyun Liu et al.
Jingjing Dong et al.
Cancer patients often suffer from depression, the presence of which promotes the deterioration of the cancer patient's condition and thus affects the patient's survival. However, the exact mechanisms underlying the relationship between depr...
Review
Immunology. 2025 May 8. DOI:10.1111/imm.13933 2025