Neutrophils in the Bone Marrow Express DEC205, Guiding Their Migration to Inflamed Tissues [0.03%]
骨髓中的中性粒细胞表达DEC205指导它们迁移到炎症组织
Shiying Jin,Xuan Lei,Sonali Singh et al.
Shiying Jin et al.
The surface molecule DEC205 (CD205) is well-characterised in murine dendritic cells (DCs) as an antigen uptake receptor. However, recent studies have also identified its expression in other leukocytes, including B cells and neutrophils. In ...
Distinct Activation and Functional Features of CD307c+ T Lymphocytes in Peripheral Blood as Diagnostic and Prognostic Markers in Breast Cancer [0.03%]
CD307c+T淋巴细胞在乳腺癌诊断和预后中的不同活化及功能特征
Ziqi Xiong,Zhenxue Li,Zhao Guan et al.
Ziqi Xiong et al.
This study aims to investigate the expression and role of CD307c in the breast cancer (BC) microenvironment, T lymphocytes of peripheral blood, particularly in BC patients at various stages, and assess its potential as a clinical diagnostic...
Bohan Xu,Guanglong Liu,Yifang Peng et al.
Bohan Xu et al.
Although extranuclear histones have been identified for a long time, their role in lymphocytes, particularly cytoplasmic histones, remains elusive. In this study, we conducted a visual and quantitative analysis of cytoplasmic histones in CD...
Loss of ALK3 Ameliorates Acute but Aggravates Chronic Lung Inflammation In Vivo [0.03%]
ALK3丢失缓解急性但加重慢性肺部炎症反应
Mathias Hochgerner,Yamei Jiang,Shenfei Sun et al.
Mathias Hochgerner et al.
ALK3 (BMPR1a) is a type-1 receptor of the TGF-β receptor superfamily. It translates signals mainly from bone morphogenetic proteins, but also from TGF-β1. Previously, we showed that specific deletion of ALK3 in antigen-presenting cells (A...
PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression-A Mini-Review [0.03%]
磷脂酰肌醇-3-激酶γ与肿瘤炎症：免疫反应和癌症进展之间的桥梁-迷你综述
Anghesom Ghebremedhin,Judith A Varner
Anghesom Ghebremedhin
Phosphatidylinositol 3-kinase gamma (PI3Kγ), a class I PI3K family member, plays a critical role in modulating inflammation and immune responses within the tumour microenvironment. Emerging evidence suggests that PI3Kγ promotes myeloid ce...
Review
Immunology. 2025 May 28. DOI:10.1111/imm.13959 2025
Araya Rattanasri,Pussadee Paensuwan,Wolfgang W W A Schamel et al.
Araya Rattanasri et al.
Non-catalytic region of tyrosine kinase 1 (Nck1) is an adaptor protein found in many cell types and plays several functions. In T cells, Nck1 is functionally associated with a T cell receptor (TCR)-mediated actin rearrangement, insulin sign...
Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis [0.03%]
利用多重成像分析描绘人类生发中心免疫图谱
Spiros Georgakis,Michail Orfanakis,Craig Fenwick et al.
Spiros Georgakis et al.
Given the role of follicular immune dynamics, especially the germinal centre, for the development of pathogen-specific antibodies, their in situ characterisation is of great importance. We have developed a multiplex immunofluorescence imagi...
IFN-λ: Unleashing Its Potential in Disease Therapies From Acute Inflammation Regulation to Cancer Immunotherapy [0.03%]
从急性炎症调节到癌症免疫治疗：释放IFN-λ的潜力用于疾病治疗
Benfeng Tang,Zhihong Liu,Huabao Xiong et al.
Benfeng Tang et al.
Type III interferons (IFN-λ), which include IFN-λ1 (or interleukin [IL]-29), IFN-λ2 (IL-28A), IFN-λ3 (IL-28B) and IFN-λ4, exert their effects through a unique receptor complex composed of interferon lambda receptor 1 (IFNLR1) and IL-10...
Review
Immunology. 2025 May 27. DOI:10.1111/imm.13954 2025
The Roles of T Cells in the Development of Metabolic Dysfunction-Associated Steatohepatitis [0.03%]
T细胞在代谢功能障碍相关脂肪肝病发病机制中的作用
Zhifa Ge,Qingwei Wu,Chengyu Lv et al.
Zhifa Ge et al.
Metabolic dysfunction-associated steatohepatitis (MASH), the progressed period of metabolic dysfunction-associated steatotic liver disease (MASLD), is a multifaceted liver disease characterised by inflammation and fibrosis that develops fro...
Review
Immunology. 2025 May 25. DOI:10.1111/imm.13943 2025
Endogenous Hydrogen Sulphide Promotes the Ex Vivo Expansion of Haematopoietic Stem Cells by Regulating the Activation of the JAK2/STAT3 Pathway [0.03%]
内源性硫化氢通过调节JAK2/STAT3信号通路活化促进血液干细胞的体外扩增
Zhiyuan Qiu,Hui Liu,Rongxuan Cao et al.
Zhiyuan Qiu et al.
Haematopoietic stem cell transplantation (HSCT) is one of the key strategies for treating various haematologic malignancies. Although there are haematopoietic stem cells (HSCs) in umbilical cord blood (UCB), the number is limited. Thus, the...