Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8+ Cells and TNF-α Levels in Target Organs, and Protects Mice From Graft-Versus-Host Disease-Related Mortality Through PPAR Activation Without Compromising the Graft-Versus-Tumour Response [0.03%]
棕榈乙醇胺（PEA）通过PPAR激活诱导脾脏调节性T细胞增加，减少靶器官中的CD8+细胞和TNF-α水平，并通过不损害移植物抗肿瘤反应来保护小鼠免受移植物抗宿主病相关的死亡
Bárbara Betônico Berg,Zara Desiree Tonidandel Campos,Gioconda Muniz Fiorenza Ruggio et al.
Bárbara Betônico Berg et al.
Graft-versus-host disease (GVHD), a secondary complication of bone marrow transplantation, leads to the development of a systemic inflammatory illness in the host, resulting in high mortality and morbidity. Current therapies lack prophylact...
Acute Plasmodium yoelii 17XNL Infection During BCG Vaccination Limits T Cell Responses and Mycobacterial Growth Inhibition [0.03%]
BCG疫苗接种期间急性感染耶尔森氏疟原虫17XNL限制T细胞的反应和分枝杆菌生长抑制作用
Emily Tangie,Nawamin Pinpathomrat,Rachel Tanner et al.
Emily Tangie et al.
Tuberculosis and malaria overlap in many sub-Saharan African countries where Bacillus Calmette Guérin (BCG) vaccination is routinely administered. The aim of this study was to determine whether the timing of BCG vaccination in relation to ...
CD59, Disulphide-Locked Human C9 and Horse C9 Inhibit Human Membrane Attack Complex Assembly by Similar Mechanisms [0.03%]
CD59、人二硫键锁定C9和马C9通过类似机制抑制人类膜攻击复合物组装
Rebekah S Cooke,Bradley A Spicer,Richard A Harrison et al.
Rebekah S Cooke et al.
Five plasma proteins, C5b, C6, C7, C8 and C9, assemble in a step-wise manner to form the membrane attack complex (MAC) which inserts into target cell membranes to cause lysis. The membrane regulator CD59 binds nascent C5b-8, preventing C9 r...
Should We Advance Our Understanding of Immunoglobulin E in Viral Immunity? [0.03%]
我们应当进一步认识免疫球蛋白E在病毒免疫中的作用吗？
Amanda Izeli Portilho,Valéria Oliveira Silva,Luis Fernando de Macedo Brigido et al.
Amanda Izeli Portilho et al.
Immunoglobulin E has been extensively studied in allergies and parasitic diseases. However, antigen-specific IgE has been identified as part of the humoral response to some viruses, including Respiratory syncytial virus (RSV), Human rhinovi...
Review
Immunology. 2025 Jun 13. DOI:10.1111/imm.70007 2025
A Novel Small Molecule ITK Inhibitor Suppresses Th2/Th17 Differentiation and Attenuates Airway Inflammation in a Mouse Model of HDM-Induced Asthma [0.03%]
一种新型的小分子ITK抑制剂可通过抑制Th2/Th17分化而减轻HDM诱导小鼠哮喘气道炎症
Zhaoxi Guo,Fuqiang Ye,Yongyou Zhang et al.
Zhaoxi Guo et al.
Interleukin (IL)-2-inducible T cell kinase (ITK) is essential for T cell receptor (TCR) signalling and plays a pivotal role in asthma pathogenesis. Thus, ITK inhibitors have therapeutic potential in T cell-derived allergic airway inflammati...
PD-1 Regulates the Glycolytic Pathway to Reverse Abnormal CD4+ T Cell Differentiation and Alleviate Hashimoto's Thyroiditis [0.03%]
PD-1通过调节糖酵解通路逆转异常CD4+T细胞分化进而缓解桥本甲状腺炎
Xiao Jiang,Tao Luo,Xinyu Zhao et al.
Xiao Jiang et al.
Hashimoto's thyroiditis (HT) is a prevalent autoimmune disease lacking a specific cure. This study endeavours to explore the role of PD-1 in modulating glycolysis during CD4+ T cell differentiation in HT. The lactate and glucose content in ...
Ying Gao,Jie Li,Fangxia Li et al.
Ying Gao et al.
The regulation of terminal differentiation of B cells into plasma cells is influenced by transcription factors, epigenetics, and cytokines. Both human and murine B cells possess the capacity to produce interleukin 16 (IL16), a pleiotropic c...
Claudio Vieira da Silva
Claudio Vieira da Silva
Chronic systemic inflammation is increasingly recognised as a central pathological state driving the global burden of non-communicable diseases, most notably cancer, and significantly exacerbated by environmental stressors linked to climate...
Review
Immunology. 2025 Jun 10. DOI:10.1111/imm.70000 2025
Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects [0.03%]
鞭毛蛋白作为疫苗佐剂和癌症免疫治疗的新进展与未来前景
Asma Talukder,Md Mijanur Rahman,Md Sifat Rahi et al.
Asma Talukder et al.
Flagellin, an essential structural protein of bacterial flagella, has emerged as a potent modulator of both specific and nonspecific immunity, demonstrating significant potential as a vaccine adjuvant and carrier. By inducing the release of...
Review
Immunology. 2025 Jun 10. DOI:10.1111/imm.70001 2025
Pannexin-1 Aggravates Inflammatory Bowel Disease via Unbalancing Macrophage Polarisation and Triggering Ferroptosis in Mice [0.03%]
连接蛋白-1通过使小鼠巨噬细胞极化失衡和触发铁死亡加重炎症性肠病
Qingfan Zheng,Yunfeng Qiu
Qingfan Zheng
Inflammatory bowel disease (IBD) is characterised by chronic inflammation in the gastrointestinal tract resulting from dysregulated immune responses to gut microflora. Intestinal macrophages play important roles in the pathogenesis of IBD. ...