Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies [0.03%]
采用单细胞技术区分活化Tregs和Tconv细胞
Julia Reinhardt,Virag Sharma,Antigoni Stavridou et al.
Julia Reinhardt et al.
Resting conventional T cells (Tconv) can be distinguished from T regulatory cells (Treg) by the canonical markers FOXP3, CD25 and CD127. However, the expression of these proteins alters after T-cell activation leading to overlap between Tco...
Oncolytic virus treatment differentially affects the CD56dim and CD56bright NK cell subsets in vivo and regulates a spectrum of human NK cell activity [0.03%]
溶瘤病毒治疗在体内对CD56dim和CD56brightNK细胞亚群产生不同的影响，并调节人类NK细胞的活性范围
Michelle Wantoch,Erica B Wilson,Alastair P Droop et al.
Michelle Wantoch et al.
Natural killer (NK) cells protect against intracellular infection and cancer. These properties are exploited in oncolytic virus (OV) therapy, where antiviral responses enhance anti-tumour immunity. We have analysed the mechanism by which re...
HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19 [0.03%]
SARS-CoV-2感染及COVID-19症状易感性的HLA-DR多态性
Stuart Astbury,Catherine J Reynolds,David K Butler et al.
Stuart Astbury et al.
SARS-CoV-2 infection results in different outcomes ranging from asymptomatic infection to mild or severe disease and death. Reasons for this diversity of outcome include differences in challenge dose, age, gender, comorbidity and host genom...
The relationship between peripheral immune response and disease severity in SARS-CoV-2-infected subjects: A cross-sectional study [0.03%]
SARS-CoV-2感染者的外周免疫反应与疾病严重程度之间的关系：一项横断面研究
Laura Otto Walter,Chandra Chiappin Cardoso,Íris Mattos Santos-Pirath et al.
Laura Otto Walter et al.
Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and marked by an intense inflammatory response and immune dysregulation in the most severe cases. In order...
Dechao Feng,Qiao Xiong,Qiang Wei et al.
Dechao Feng et al.
Prostate cancer is still a public health priority in men and the impact of this disease will be more pronounced with the ageing of the world's population. Clinical heterogeneity of prostate cancer is reflected in spatial and clonal genomic ...
Lauren Kelly,Sarah McGrath,Lewis Rodgers et al.
Lauren Kelly et al.
Annexin-A1 has a well-defined anti-inflammatory role in the innate immune system, but its function in adaptive immunity remains controversial. This glucocorticoid-induced protein has been implicated in a range of inflammatory conditions and...
Editorial: Highlighting early-career researchers-The future of Immunology [0.03%]
本期编者按：关注青年科学家——免疫学的未来
Greg M Delgoffe
Greg M Delgoffe
Editorial
Immunology. 2022 Mar;165(3):289. DOI:10.1111/imm.13446 2022
Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1 [0.03%]
应激激素通过mTORC1和昼夜节律基因PER1以CD4T细胞内在的方式抑制Th1极化
Christophe M Capelle,Anna Chen,Ni Zeng et al.
Christophe M Capelle et al.
Stress hormones are believed to skew the CD4 T-cell differentiation towards a Th2 response via a T-cell-extrinsic mechanism. Using isolated primary human naïve and memory CD4 T cells, here we show that both adrenergic- and glucocorticoid-m...
HLA-dependent variation in SARS-CoV-2 CD8 + T cell cross-reactivity with human coronaviruses [0.03%]
人冠状病毒的SARS-CoV-2 CD8+T细胞交叉反应性存在HLA依赖性变异
Paul R Buckley,Chloe H Lee,Mariana Pereira Pinho et al.
Paul R Buckley et al.
The conditions and extent of cross-protective immunity between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and common-cold human coronaviruses (HCoVs) remain open despite several reports of pre-existing T cell immunity to S...
Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid [0.03%]
金黄色葡萄球菌通过脂壁酸控制二十烷类和专业促进解决介导物的产生
Laura Miek,Paul M Jordan,Kerstin Günther et al.
Laura Miek et al.
Staphylococcus aureus causes severe infections associated with inflammation, such as sepsis or osteomyelitis. Inflammatory processes are regulated by distinct lipid mediators (LMs) but how their biosynthetic pathways are orchestrated in S. ...