Editorial: Perspectives on the landscape of immunology from Nikhil Joshi [0.03%]
观点·综述：尼基尔·乔西点评免疫学进展
Nikhil S Joshi,Greg M Delgoffe
Nikhil S Joshi
Editorial
Immunology. 2022 Apr;165(4):369-370. DOI:10.1111/imm.13467 2022
Interferon-α promotes MHC I antigen presentation of islet β cells through STAT1-IRF7 pathway in type 1 diabetes [0.03%]
干扰素α通过STAT1-IRF7通路促进1型糖尿病β细胞MHC I类抗原呈递
Hemin Jiang,Yue Li,Min Shen et al.
Hemin Jiang et al.
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease. Increased incidence of T1D was reported in patients receiving IFN-α treatment. However, the exact mechanisms of IFN-α that facilitate the pathogenesis of T1D are not fully und...
Siglec-5 is an inhibitory immune checkpoint molecule for human T cells [0.03%]
.siglec-5是人类t细胞的抑制性免疫检查点分子
Aleksandra Vuchkovska,David G Glanville,Gina M Scurti et al.
Aleksandra Vuchkovska et al.
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunoglobulin-type lectins that mediate protein-carbohydrate interactions via sialic acids attached to glycoproteins or glycolipids. Most of the CD33-related Siglecs...
Targeting glycolysis in Th2 cells by pterostilbene attenuates clinical severities in an asthmatic mouse model and IL-4 production in peripheral blood from asthmatic patients [0.03%]
白藜芦醇通过抑制小鼠哮喘模型中Th2细胞的糖酵解减轻临床症状并降低外周血中哮喘患者IL-4产生水平
Chuan-Teng Liu,Ying-Chyi Song,Tsai-Chen Wu et al.
Chuan-Teng Liu et al.
Asthma, a major non-communicable disease, affects both adults and children and is associated with high morbidity compared with other chronic diseases. The glycolysis-associated activation of type 2 helper T (Th2) cells is the critical immun...
The clinical relevance of epithelial-mesenchymal transition and its correlations with tumorigenic immune infiltrates in hepatocellular carcinoma [0.03%]
上皮间质转化在肝细胞癌的临床意义及其与肿瘤特异性免疫微环境的关系研究
Zhi-Qiang Qiu,Xiang Wang,Xiang-Wen Ji et al.
Zhi-Qiang Qiu et al.
Hepatocellular carcinoma (HCC) is a cancer with extremely high mortality. Epithelial-mesenchymal transition (EMT) may play an important role in the occurrence, invasion and prognosis of HCC; however, its relationship with immunity in HCC ha...
Developing an immune-related gene prognostic index associated with progression and providing new insights into the tumor immune microenvironment of prostate cancer [0.03%]
开发与前列腺癌进展相关的免疫相关基因预后指数并为肿瘤免疫微环境提供新见解
Dechao Feng,Facai Zhang,Dengxiong Li et al.
Dechao Feng et al.
We developed an immune-related gene prognostic index (IGPI) associated with progression and provided new insights into the tumour immune microenvironment (TIME) for prostate cancer (PCA) patients undergoing radical prostatectomy. All analys...
Meta-Analysis
Immunology. 2022 Jun;166(2):197-209. DOI:10.1111/imm.13466 2022
NK-cell exhaustion, B-cell exhaustion and T-cell exhaustion-the differences and similarities [0.03%]
自然杀伤细胞、B淋巴细胞和T淋巴细胞耗竭的异同点
Kevin Roe
Kevin Roe
T-cell exhaustion has been extensively researched, compared with B-cell exhaustion and NK-cell exhaustion, which have received considerably less attention; and there is less of a consensus on the precise definitions of NK-cell and B-cell ex...
CTLA4Ig/VISTAIg combination therapy selectively induces CD4+ T cell-mediated immune tolerance by targeting the SOCS1 signaling pathway in porcine islet xenotransplantation [0.03%]
CTLA4Ig/VISTA Ig联合治疗通过靶向SOCS1信号通路诱导CD4⁺T细胞介导的免疫耐受以改善猪胰岛异种移植效果
Dan Wang,Xue Bai,Bin Wang et al.
Dan Wang et al.
T cell inhibitory receptors can regulate the proliferation or function of T cells by binding to their ligands and present a unique opportunity to manage destructive immune responses during porcine islet xenotransplantation. We applied ex vi...
The roles of interleukin-1 receptor accessory protein in certain inflammatory conditions [0.03%]
白细胞介素-1受体辅因子在特定炎症反应中的作用机制研究
Ali Zarezadeh Mehrabadi,Nazanin Aghamohamadi,Majid Khoshmirsafa et al.
Ali Zarezadeh Mehrabadi et al.
Interleukin-1 receptor accessory protein (IL-1RAcP) is a member of the immunoglobulin superfamily proteins consisting of soluble and membranous isoforms. IL-1RAcP plays an essential role in the signaling of the IL-1 family cytokines such as...
Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota [0.03%]
肠道巨噬细胞代谢具有区室特异性并受微生物群调节
Nicholas A Scott,Melissa A E Lawson,Ryan James Hodgetts et al.
Nicholas A Scott et al.
Intestinal macrophages play a vital role in the maintenance of gut homeostasis through signals derived from the microbiota. We previously demonstrated that microbial-derived metabolites can shape the metabolic functions of macrophages. Here...