A cross-kingdom view on the immunomodulatory role of MIF/D-DT proteins in mammalian and plant Pseudomonas infections [0.03%]
从跨王国的角度审视MIF/D-DT蛋白在哺乳动物和植物假单胞菌感染中对免疫调节的作用
Ralph Panstruga,Seamas C Donnelly,Jürgen Bernhagen
Ralph Panstruga
Gram-negative Pseudomonas bacteria are largely harmless saprotrophs, but some species can be potent pathogens of both plants and mammals. Macrophage migration-inhibitory factor (MIF) and its homologue D-dopachrome tautomerase (D-DT, also re...
Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity [0.03%]
治疗性抗体糖基化影响抗原识别和免疫原性
Babette Wolf,Mateusz Piksa,Isabelle Beley et al.
Babette Wolf et al.
In this study we show that glycosylation is relevant for immune recognition of therapeutic antibodies, and that defined glycan structures can modulate immunogenicity. Concerns regarding immunogenicity arise from the high heterogeneity in gl...
Activation of T cell checkpoint pathways during β-cell antigen presentation by engineered dendritic cells promotes protection from type 1 diabetes [0.03%]
工程化树突细胞在β细胞抗原呈递过程中活化T细胞检查点通路可促进1型糖尿病的预防
Radhika R Gudi,Nicolas Perez,Subha Karumuthil-Melethil et al.
Radhika R Gudi et al.
Defective immune regulation has been recognized in type 1 diabetes (T1D). Immune regulatory T cell check-point receptors, which are generally upregulated on activated T cells, have been the molecules of attention as therapeutic targets for ...
T cell-intrinsic miR-155 is required for Th2 and Th17-biased responses in acute and chronic airway inflammation by targeting several different transcription factors [0.03%]
靶向多个不同转录因子后，T细胞固有的miR-155在急性及慢性气道炎症中需要产生Th2和Th17偏向性反应
Hyo Jin Kim,Seong Ok Park,Hee Won Byeon et al.
Hyo Jin Kim et al.
Asthmatic airway inflammation is divided into two typical endotypes: Th2-mediated eosinophilic and Th1- or Th17-mediated neutrophilic airway inflammation. The miRNA miR-155 has well-documented roles in the regulation of adaptive T-cell resp...
Wei Fan,Weidi Huang,Jiayi Chen et al.
Wei Fan et al.
Microglia, the resident immune cells in the retina and nervous system, make irreplaceable contributions to the maintenance of normal homeostasis and immune surveillance of these systems. Recently, great progress has been made in determining...
The effect of age on the magnitude and longevity of Th1-directed CD4 T-cell responses to SARS-CoV-2 [0.03%]
年龄对SARS-CoV-2特异性Th1定向CD4 T细胞反应幅度和持久性的影响
Ryan G Nattrass,Lisa Krafft,Polina Zjablovskaja et al.
Ryan G Nattrass et al.
Age is associated with changes in the immune system which increase the risk for severe COVID-19. Here, we investigate SARS-CoV-2-reactive CD4 T cells from individuals recovered from SARS-CoV-2 infection with mild COVID-19 symptoms after 3, ...
Corrigendum [0.03%]
勘误表
Published Erratum
Immunology. 2022 Jun;166(2):265. DOI:10.1111/imm.13474 2022
Adoptive transfer of IL-4 reprogrammed Tc17 cells elicits anti-tumour immunity through functional plasticity [0.03%]
白介素4重编程的Tc17细胞过继转移通过功能重塑诱导抗肿瘤免疫响应
Chiung-Hui Liu,Bo-Shiou Lin,Mei-Yao Wu et al.
Chiung-Hui Liu et al.
Ability of IL-17-producing CD8+ T cells (Tc17) to transform into cytotoxic anti-tumour effectors makes them a promising candidate for immune effector cell (IEC) therapy. However, key factors regulating Tc17 reprogramming remain poorly defin...
1,25-Dihydroxyvitamin D3 suppresses CD4+ T-cell effector functionality by inhibition of glycolysis [0.03%]
1,25-二羟基维生素D3通过抑制糖酵解来抑制CD4+T细胞的效应功能
Emma L Bishop,Nancy H Gudgeon,Gillian M Mackie et al.
Emma L Bishop et al.
In CD4+ T helper cells, the active form of vitamin D3 , 1,25-dihydroxyvitamin D3 (1,25D) suppresses production of inflammatory cytokines, including interferon-gamma (IFN-γ), but the mechanisms for this are not yet fully defined. In innate ...
Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles [0.03%]
肿瘤相关抗原肽存在于癌细胞系衍生外泌体的人白细胞抗原I类配体组中
Pankaj Kumar,Caitlin Boyne,Sydney Brown et al.
Pankaj Kumar et al.
The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells to detect cancer-related antigenic peptides has refocused the need to fully understand the repertoire of peptides being presen...