GD2-CAR T Cell Therapy for H3K27M+ Diffuse Intrinsic Pontine Glioma: A Phase I Clinical Trial and Mechanistic Insights [0.03%]
H3K27M阳性弥漫内生性脑桥胶质瘤的GD2-CAR T细胞治疗：Ⅰ期临床试验及机制研究
Congfa Jiang,Hening Xu,Jianqiao Shentu et al.
Congfa Jiang et al.
Use of a Foamy-Virus Vector System to Produce an 'Off-the-Shelf' Fcγ-CR-T Cell Product for the Treatment of Haematological and Solid Tumour Malignancies [0.03%]
用于制造“即用型”Fcγ-CR-T细胞产品治疗血液系统恶性肿瘤和实体瘤的发泡沫病毒载体系统的研究
Ioanna Lazana,Emmanouil Simantirakis,Evangelos Kourous et al.
Ioanna Lazana et al.
The emergence of chimeric antigen receptor (CAR)-T cells has revolutionised the therapeutic landscape of hematologic malignancies, with limited translation only to solid organ malignancies. Furthermore, safety concerns have recently been ra...
Raminta Venskutonytė,Sven Kjellström,Emily Amelia O&#x;Connor et al.
Raminta Venskutonytė et al.
The major histocompatibility complex (MHC) plays a key role in pathogen recognition as part of the adaptive immune system. MHC I gene copy numbers in birds of the order Passeriformes (songbirds) are substantially larger compared to other bi...
Ascaris Lumbricoides Cystatin Impairs IL-1β Maturation and CD14 Expression in Human Monocytes [0.03%]
人单核细胞中芽囊原虫半胱氨酸蛋白酶抑制剂对IL-1β成熟和CD14表达的调控作用研究
Ana Lozano,Josefina Zakzuk,Nathalie Acevedo et al.
Ana Lozano et al.
Ascaris lumbricoides cystatin (Al-CPI), a cysteine protease inhibitor, has shown anti-inflammatory effects in models of house dust mite-induced respiratory allergy and experimental colitis. Since monocytes are primary targets of cystatins, ...
The Role and Mechanism of Anti-ICOS mAb in Experimental Autoimmune Encephalomyelitis [0.03%]
抗ICOS单克隆抗体在实验性自身免疫性脑脊髓炎中的作用及机制研究
Minjun Xiao,Yun Zhao,Xue Zhang et al.
Minjun Xiao et al.
Targeting costimulatory signalling pathways, especially inducible T-cell costimulatory (ICOS)-ICOS ligand(ICOSL) co-stimulatory signal, has been widely used as a therapeutic target in autoimmune diseases. Multiple sclerosis (MS) is an autoi...
Distinct T Cell Receptor Clonotypes in the Sardinian Population Highlight the Role of Mucosal-Associated Invariant T Cells and Invariant Natural Killer T Cells in Multiple Sclerosis [0.03%]
沙丁尼亚人群中的不同T细胞受体克隆型突显了黏膜相关不变性T细胞和不变自然杀伤T细胞在多发性硬化症中的作用
Jiaxin Shen,Elena Rita Simula,Yisu Liu et al.
Jiaxin Shen et al.
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory disease of the central nervous system, driven by T-cell mediated immune responses. Studying T-cell receptor (TCR) clonotypes specific to MS in distinct populations can provide i...
CD73 Expression by CD4+ T Cells Marks Early Effector Memory T Cells [0.03%]
CD4⁺ T 细胞中的 CD73 表达标志着早期效应记忆 T 细胞
Luxia Chen,Sabine Ring,Anna Jurga et al.
Luxia Chen et al.
CD73 is a membrane bound ectoenzyme, dephosphorylating adenosine mono- and di-phosphate to immunosuppressive adenosine. It is strongly expressed by CD4+CD25+Foxp3+ regulatory T cells, but when analysing conventional CD4+ T cells only 50% ex...
Radiofrequency Ablation and Immunotherapy: Orchestrating the Immune Microenvironment for Improved Hepatocellular Carcinoma Control [0.03%]
射频消融和免疫治疗：调控免疫微环境以改善肝细胞癌控制能力
Liu Yang,Shuhang Wei,Zongxin Liu et al.
Liu Yang et al.
Radiofrequency ablation (RFA) is a radical treatment modality for early-stage hepatocellular carcinoma (HCC). In addition to directly eliminating tumour cells, RFA induces changes in infiltrating cells within the liver tumour immune microen...
Review
Immunology. 2025 Jun 26. DOI:10.1111/imm.70004 2025
Baoqing Xu,Jianbin Ji,Lingling Ma et al.
Baoqing Xu et al.
γδT cells play a crucial role in inflammatory bowel disease (IBD). Studies have shown that the number, subsets and secreted cytokines of γδT cells undergo changes in IBD. However, whether γδT cells are beneficial or detrimental in IBD...
Review
Immunology. 2025 Jun 25. DOI:10.1111/imm.70012 2025