Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function [0.03%]
信号转导和转录激活蛋白（STAT）调控黏膜相关不变性T细胞（MAIT）的功能
Olivia J Cheng,Eimear K Ryan,Michael Bennett et al.
Olivia J Cheng et al.
Mucosal-Associated Invariant T (MAIT) cells are a subset of T cells with potential for rapid cytotoxic and inflammatory functions. Dysregulation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway, partic...
The Role of NLRP1, AIM2 and MEFV Inflammasomes in the High-Intensity Interval Training of Individuals With Obesity [0.03%]
肥胖人群高强度间歇训练中NLRP1、AIM2和MEFV炎症小体的作用
Ana Luíza Pereira Assunção Silveira,Daniela Alves de Abreu,Amanda de Lima Santos Musto et al.
Ana Luíza Pereira Assunção Silveira et al.
Obesity is a chronic disease associated with systemic inflammation caused by excess visceral fat and pro-inflammatory cytokines such as IL-1β and IL-6. Inflammasomes-particularly those involving genes such as NLRP1, AIM2 and MEFV-play a ke...
The Immunosuppressive Microenvironment of Glioblastoma: Mechanisms, Clinical Challenges and Future Directions [0.03%]
胶质母细胞瘤的免疫抑制微环境：机制、临床挑战及未来方向
Changming Pang,Yan Wang
Changming Pang
Glioblastoma (GBM) remains highly lethal due to intrinsic and extrinsic mechanisms, of which the immunosuppressive tumour microenvironment (TME) collectively limits treatment efficacy. This review synthesises recent advances in understandin...
Review
Immunology. 2025 Dec 19. DOI:10.1111/imm.70087 2025
Lactate and Lactylation in Immune Cell Function and Autoimmune Diseases: Mechanisms and Therapeutic Potential [0.03%]
乳酸和乳酸化在免疫细胞功能和自身免疫疾病中的作用机制及治疗潜力
Yiying Yang,Ying Zhang,Ke Liu et al.
Yiying Yang et al.
Lactate metabolism plays a crucial role in immune cell function, particularly during inflammation or metabolic stress. Under these conditions, immune cells often undergo a metabolic shift towards glycolysis, resulting in increased lactate p...
Review
Immunology. 2025 Dec 16. DOI:10.1111/imm.70075 2025
Neutrophil Extracellular Mitochondria Are Endowed With Direct Bacteriostatic/Bactericidal Activity on Staphylococcus aureus [0.03%]
中性粒细胞胞外线粒体具有直接抑制/杀灭金黄色葡萄球菌的作用
Miguel Angel Rivero-Silva,María Maximina Bertha Moreno-Altamirano,Ricardo Mondragón-Flores et al.
Miguel Angel Rivero-Silva et al.
Neutrophils are the most abundant type of leukocyte found in human peripheral blood, with approximately 1 × 1011 produced daily in the bone marrow. They play a crucial role as the first line of defence against microbial infections. Neutrop...
The Bidirectional Orchestrator: Ficolin-1's Pivotal Role in Innate Immunity and Disease [0.03%]
双向调控者：Ficoln-1在固有免疫和疾病中的关键作用
Cao Yu,Li Lei,Ji Zhenhua et al.
Cao Yu et al.
Ficolin-1 (FCN1, M-FCN), the key pattern recognition molecule of the innate immune system, possesses a collagen-like domain and a fibrinogen-like domain, exhibiting bidirectional immunomodulatory functions that influence immune homeostasis ...
Review
Immunology. 2025 Dec 15. DOI:10.1111/imm.70085 2025
The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation [0.03%]
CREB3L1在潜伏和重症结核病免疫调节中的双重作用机制研究
Felipe T Lima,Ricardo C Castro,Francisco R Javier et al.
Felipe T Lima et al.
During tuberculosis (TB), organ-specific immune responses and intracellular pathways play critical roles in disease progression and prognosis. Identifying genes that regulate these immune mechanisms remains a key challenge in improving TB m...
Unravelling the Immunological Enigma of Sickle Cell Disease: Current Understanding and Future Directions [0.03%]
解开镰状细胞病免疫学谜团：当前理解与未来方向
Sumit Jamwal,Cecelia Calhoun,Subhasis Mohanty et al.
Sumit Jamwal et al.
Sickle cell disease (SCD) is caused by a mutation in the β-globin gene, resulting in abnormal haemoglobin S (HbS). Beyond genetic mutation, dysregulation of immune-related genes such as those regulating NF-κB signalling, inflammasome acti...
Review
Immunology. 2025 Dec 12. DOI:10.1111/imm.70080 2025
Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS-Induced Colitis [0.03%]
肠道微生物组组成和粪便代谢物的差异与DSS诱导结肠炎的易感性有关
Jessica M Till,Orion D Brock,Elyza A Do et al.
Jessica M Till et al.
Variation in microbiome composition is linked to differences in intestinal immune phenotypes and can be leveraged to identify microbiome-driven contributions to phenotypes of interest. Furthermore, such variation has been associated with di...
Mass-Standardised Differential Antibody Binding to a Spectrum of SARS-CoV-2 Variant Spike Proteins: Wuhan, Alpha, Beta, Gamma, Delta, Omicron BA.1, BA.4/5, BA.2.75 and BA.2.12.1 Variants-Antibody Immunity Endotypes [0.03%]
针对新冠病毒变异株刺突蛋白的抗体结合差异性大规模标化研究：武汉、阿尔法、贝塔、伽马、德尔塔、奥密克戎BA.1、BA.4/5、BA.2.75和BA.2.12.1变异株-抗体免疫分型
Philip H James-Pemberton,Shivali Kohli,Jordan Twynham et al.
Philip H James-Pemberton et al.
A fully mass-standardised quantitative comparative analysis of the differential antibody binding to spike variant proteins to SARS-CoV-2 has been performed for the variants: Wuhan, Alpha, Beta, Gamma, Delta and the Omicron variants BA.1, BA...