Lymph node stromal cells support the maturation of pre-DCs into cDC-like cells via colony-stimulating factor 1 [0.03%]
淋巴结基质细胞通过刺激因子支持前DC向cDC样细胞成熟发育
Carolin Wiechers,Joern Pezoldt,Michael Beckstette et al.
Carolin Wiechers et al.
Conventional dendritic cells (cDCs) arise from committed precursor dendritic cells (pre-DCs) in the bone marrow that continuously seed the periphery. Pre-DCs and other upstream progenitors proliferate and mature in response to Fms-related r...
Lung adenocarcinoma manifesting as subsolid nodule potentially represents tumour in the equilibrium phase of immunoediting [0.03%]
表现为亚实性结节的肺腺癌可能代表免疫编辑平衡期的肿瘤
Rongxin Xiao,Yi Ma,Hao Li et al.
Rongxin Xiao et al.
Lung adenocarcinomas manifesting as subsolid nodules (SSN-LUADs) possess distinct dormant behaviour. This study was designed to compare the immune landscapes of normal lungs (nLungs), SSN-LUADs and LUADs manifesting as solid nodules (SN-LUA...
Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy [0.03%]
髓样分化因子-2活化心肌病患者的单核细胞
Rico Feldtmann,Andreas Kümmel,Bishwas Chamling et al.
Rico Feldtmann et al.
Plasma levels of myeloid differentiation factor-2 (MD-2), a co-receptor of toll-like-receptor 4 (TLR4), independently predict mortality in patients with dilated cardiomyopathy (DCM). We tested whether monocyte activation by MD-2 contributes...
TIM3/CEACAM1 pathway involves in myeloid-derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysplastic syndrome [0.03%]
TIM3/CEACAM1途径参与髓系衍生抑制细胞诱导的骨髓炎性微环境中的CD8+t细胞衰竭在骨髓增生异常综合征中发挥作用
Shunjie Yu,Xiaotong Ren,Fanqiao Meng et al.
Shunjie Yu et al.
Myeloid-derived suppressor cells (MDSC) induced cellular immune deficiency and bone marrow inflammatory microenvironment play an important role in the pathogenesis and progression of myelodysplastic syndrome (MDS), but the underlying mechan...
Jim Q Ho,Mohammad Reza Sepand,Banafsheh Bigdelou et al.
Jim Q Ho et al.
The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and has a complex interaction with the immune system, including gr...
Pathogenetic role and clinical significance of interleukin-1β in cancer [0.03%]
细胞因子IL-1β在癌症发病机制及临床意义中的作用研究进展
Anna M Malkova,Anna R Gubal,Anastasia L Petrova et al.
Anna M Malkova et al.
In recent years, pro-oncogenic mechanisms of the tumour microenvironment (ТМЕ) have been actively discussed. One of the main cytokines of the TМЕ is interleukin-1 beta (IL-1β), which exhibits proinflammatory properties. Some studies h...
Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum [0.03%]
细胞起源和生态位可用性决定了腹膜巨噬细胞定植腔室和大网膜的能力
Pieter A Louwe,Stuart J Forbes,Cécile Bénézech et al.
Pieter A Louwe et al.
The relationship between macrophages of the peritoneal cavity and the adjacent omentum remains poorly understood. Here, we describe two populations of omental macrophages distinguished by CD102 expression and use an adoptive cell transfer a...
Greg M Delgoffe
Greg M Delgoffe
Editorial
Immunology. 2022 May;166(1):1. DOI:10.1111/imm.13478 2022
cGAS modulates cytokine secretion and bacterial burdens by altering the release of mitochondrial DNA in pseudomonas pulmonary infection [0.03%]
环鸟苷酸-腺苷酸合成酶通过改变铜绿假单胞菌肺部感染中线粒体DNA的释放来调节细胞因子分泌和细菌负荷
Biao Wang,Chuanmin Zhou,Qun Wu et al.
Biao Wang et al.
Cyclic GMP-AMP synthase (cGAS) is essential for fighting against viruses and bacteria, but how cGAS is involved in host immune response remains largely elusive. Here, we uncover the crucial role of cGAS in host immunity based on a Pseudomon...