The kinetics of IgG subclasses and contributions to neutralizing activity against SARS-CoV-2 wild-type strain and variants in healthy adults immunized with inactivated vaccine [0.03%]
健康成年人接种灭活疫苗后针对新冠病毒原型株及变异株的IgG亚类动力学特征及其中和活性贡献分析
Weixin Chen,Lichi Zhang,Juan Li et al.
Weixin Chen et al.
Neutralizing antibody is an important indicator of vaccine efficacy, of which IgG is the main component. IgG can be divided into four subclasses. Up to now, studies analysing the humoral response to SARS-CoV-2 vaccination have mostly focuse...
The functional diversity of tissue-resident natural killer cells against infection [0.03%]
组织驻留的自然杀伤细胞抗感染的功能多样性
Toby Le,Roger Keith Reeves,Lyle Robert McKinnon
Toby Le
For decades, studies of natural killer (NK) cells have focused on those found in peripheral blood (PBNK cells) as the prototype for NK cell biology. Only recently have researchers begun to explore the diversity of tissue-resident NK (tr-NK)...
Victor Araujo Correa,Amanda Izeli Portilho,Elizabeth De Gaspari
Victor Araujo Correa
Vaccines are the most effective tool to control infectious diseases, which provoke significant morbidity and mortality rates. Most vaccines are administered through the parenteral route and can elicit a robust systemic humoral response, but...
Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment [0.03%]
Keap1通过G9a-GLP和NFκB p50招募调节病毒诱导基因的转录
Veronica Elizabeth Burns,Tom Klaus Kerppola
Veronica Elizabeth Burns
Cells must control genes that are induced by virus infection to mitigate deleterious consequences of inflammation. We investigated the mechanisms whereby Keap1 moderates the transcription of genes that are induced by Sendai virus infection ...
Greg M Delgoffe
Greg M Delgoffe
Editorial
Immunology. 2022 Jul;166(3):267. DOI:10.1111/imm.13521 2022
Update on the current knowledge of lymphatic drainage system and its emerging roles in glioma management [0.03%]
关于淋巴引流系统当前知识及其在胶质瘤管理中新兴作用的更新
Yu-Long Lan,Hongjin Wang,Aiqin Chen et al.
Yu-Long Lan et al.
The draining of brain interstitial fluid (ISF) to cerebrospinal fluid (CSF) and the subsequent draining of CSF to meningeal lymphatics is well-known. Nonetheless, its role in the development of glioma is a remarkable finding that has to be ...
Jia Wang,Ruining Gong,Chenyang Zhao et al.
Jia Wang et al.
The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcripti...
Peritoneal GATA6+ macrophage drives hepatic immunopathogenesis and maintains the Treg cell niche in the liver [0.03%]
腹膜GATA6+巨噬细胞驱动肝脏免疫病理发生并维持肝内调节性T细胞生态niche
Hao Chang,Yangyue Ni,Chunxiang Shen et al.
Hao Chang et al.
The source of macrophages that contribute to human liver disease remains poorly understood. The purpose of this study is to investigate the functional mechanism of peritoneal macrophages in the development of hepatic immunopathology. By per...
Luminal bacteria coated with IgA and IgG during intestinal inflammation as a new and abundant stimulus for colonic macrophages [0.03%]
肠道炎症期间包裹在IgA和IgG中的腔内细菌作为结肠巨噬细胞的新而丰富的刺激物
Lisa Maccio-Maretto,Virginia Piqueras,Bibiana E Barrios et al.
Lisa Maccio-Maretto et al.
In the gut, secretory immunoglobulin A is the predominant humoral response against commensals, although healthy hosts also produce microbiota-specific IgG antibodies. During intestinal inflammation, the content of IgG in the lumen increases...
CIS and TGF-β regulatory pathways influence immunity to bacterial infection [0.03%]
CIS和TGF-β调节途径影响细菌感染的免疫反应
Timothy R McCulloch,Gustavo R Rossi,Jaring Schreuder et al.
Timothy R McCulloch et al.
Immunotherapy has revolutionized cancer therapy by reactivating tumour-resident cytotoxic lymphocytes. More recently, immunotherapy has emerged to restore immunity against infectious agents, including bacterial infections. Immunotherapy pri...