Fcγ RIIb protects from reperfusion injury by controlling antibody and type I IFN-mediated tissue injury and death [0.03%]
Fcγ RIIb通过控制抗体和I型干扰素介导的组织损伤和死亡来预防再灌注损伤
Camila Bernardo de Brito,Fernando Roque Ascenção,Raquel Duque Nascimento Arifa et al.
Camila Bernardo de Brito et al.
Intestinal ischemia and reperfusion (I/R) is accompanied by an exacerbated inflammatory response characterized by deposition of IgG, release of inflammatory mediators, and intense neutrophil influx in the small intestine, resulting in sever...
Distinct activities of Vδ1+ T-cells upon different cytomegalovirus reactivation status after haematopoietic transplantation [0.03%]
不同移植物抗宿主病状态下造血干细胞移植后巨细胞病毒再活化对Vδ1阳性T细胞不同作用机制的研究
Ruoyang Liu,Ning Wu,Haitao Gao et al.
Ruoyang Liu et al.
Cytomegalovirus (CMV) reactivation is the most frequent viral infectious complication correlating to non-relapse mortality after allogeneic haematopoietic cell transplantation (alloHCT). The intrinsic anti-CMV immunity has not been complete...
E3 ubiquitin ligase MID1 ubiquitinates and degrades type-I interferon receptor 2 [0.03%]
E3连接酶MID1泛素化并降解I型干扰素受体IFNR2
Xiangjie Chen,Qian Zhao,Ying Xu et al.
Xiangjie Chen et al.
Type I interferon (IFN-I) is a common biological molecule used for the treatment of viral diseases. However, the clinical antiviral efficacy of IFN-I needs to be greatly improved. In this study, IFN-I receptor 2 (IFNAR2) was revealed to und...
CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2 [0.03%]
CD5L通过扩展CD11c hoch肺泡巨噬细胞并抑制NLRP3炎性小体的活化来减弱过敏性气道炎症（HDAC2）
Danlin Weng,Song Gao,Hailan Shen et al.
Danlin Weng et al.
Allergic asthma is an airway inflammatory disease dominated by type 2 immune responses and there is currently no curative therapy for asthma. CD5-like antigen (CD5L) has been known to be involved in a variety of inflammatory diseases. Howev...
Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus [0.03%]
条件性敲除雌激素受体α影响CD11c+细胞在系统性红斑狼疮小鼠中的存活和炎症因子谱型
Mara L Lennard Richard,Jena R Wirth,Aastha Khatiwada et al.
Mara L Lennard Richard et al.
Oestrogen and oestrogen receptor alpha (ERα) have been implicated in systemic lupus erythematosus pathogenesis. ERα signalling influences dendritic cell (DC) development and function, as well as inflammation and downstream immune response...
Immune responses to Sinopharm/BBIBP-CorV in individuals in Sri Lanka [0.03%]
斯里兰卡人群接种国药集团北京生物研究所新冠疫苗后的免疫反应
Chandima Jeewandara,Inoka Sepali Aberathna,Pradeep Darshana Pushpakumara et al.
Chandima Jeewandara et al.
As there are limited data of the immunogenicity of the Sinopharm/BBIBP-CorV in different populations, antibody responses against different SARS-CoV-2 variants of concern and T cell responses, we investigated the immunogenicity of the vaccin...
Immunogenicity and safety of SpikoGen®, an adjuvanted recombinant SARS-CoV-2 spike protein vaccine as a homologous and heterologous booster vaccination: A randomized placebo-controlled trial [0.03%]
序贯或同源加强免疫斯波克ゲン®新冠疫苗（基于重组新型冠状病毒S蛋白疫苗）的免疫原性和安全性：随机对照试验
Payam Tabarsi,Nassim Anjidani,Ramin Shahpari et al.
Payam Tabarsi et al.
SpikoGen® is a subunit recombinant spike protein vaccine combined with Advax-CpG55.2™ adjuvant. This COVID-19 vaccine was shown to be safe, immunogenic and efficacious in previous clinical trials. This study aimed to assess the safety and...
Randomized Controlled Trial
Immunology. 2022 Nov;167(3):340-353. DOI:10.1111/imm.13540 2022
Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β [0.03%]
Hp-TGM的气道过敏性嗜酸性粒细胞减少作用：一种线虫来源的TGF-β类似物
Caroline Chauché,Orhan Rasid,Anne-Marie Donachie et al.
Caroline Chauché et al.
Type 2-high asthma is a chronic inflammatory disease of the airways which is increasingly prevalent in countries where helminth parasite infections are rare, and characterized by T helper 2 (Th2)-dependent accumulation of eosinophils in the...
Characterization of the immune regulatory property of CD22+ CD9+ B cells [0.03%]
CD22+ CD9+ B细胞的免疫调节特性分析
Gui Yang,Limin Suo,Suqin Hu et al.
Gui Yang et al.
Immunodisruptive homeostasis is recognized in allergic disorders. The mechanism of restoration of immunologic homeostasis in the body is not fully understood. Galectin-9 (Gal9) and CD22 have immune regulatory functions. The goal of this stu...
Calcium controlled NFATc1 activation enhances suppressive capacity of regulatory T cells isolated from generalized vitiligo patients [0.03%]
钙离子调控的NFATc1活化增强泛发性白癜风患者调节性T细胞的抑制功能
Prashant S Giri,Ankit H Bharti,Rasheedunnisa Begum et al.
Prashant S Giri et al.
NFATs and FOXP3 are linked with impaired regulatory T-cells (Tregs) in generalized vitiligo (GV). To elucidate calcium mediated NFATc1 signalling pathway and its effect on Treg suppressive capacity in GV. Calcium levels, calcineurin, NFATc1...