Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage [0.03%]
对SARS-CoV-2患者心脏组织的转录组分析确定了DNA损伤
Arutha Kulasinghe,Ning Liu,Chin Wee Tan et al.
Arutha Kulasinghe et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ complications. In comparison with the 2009 pandemic (pH1N1), SARS-CoV-2 infection is likely to lead to more severe...
Fei Li,Huiling Liu,Dan Zhang et al.
Fei Li et al.
The metabolic reprogramming during T cell activation and differentiation affects T cell fate and immune responses. Cell metabolism may serve as the driving force that induces epigenetic modifications, contributing to regulating T cell diffe...
Single-cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer [0.03%]
单细胞景观和浸润B细胞的临床结局在结直肠癌中的作用
Jie Xia,Zhangjuan Xie,Gengming Niu et al.
Jie Xia et al.
B cells constitute a major component of infiltrating immune cells in colorectal cancer (CRC). However, the characteristics of B cells and their clinical significance remain unclear. In this study, using single-cell RNA sequencing and multic...
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis [0.03%]
子宫内膜异位病灶中异常种植的子宫内膜基质细胞通过Mettl3/Trib1/ERK/STAT3信号通路诱导巨噬细胞M2极化产生乳酸
Yanling Gou,Han Wang,Tong Wang et al.
Yanling Gou et al.
Endometriosis is a gynaecological condition characterized by the growth of endometrium-like tissues within and outside of the pelvic cavity. Recent studies have demonstrated that aberrant infiltration of M2 macrophages is mainly responsible...
Circular RNA ACTR2 activates M2 polarization of macrophages through activating Yes-associated protein signalling and contributes to renal fibrosis [0.03%]
Circular RNA ACTR2通过激活Yes相关蛋白信号促进巨噬细胞M2极化并参与肾纤维化
Hua Fu,Ling Chu,Yi-Shu Yuan et al.
Hua Fu et al.
Macrophages, associated with their heterogenous and dynamic polarization status, actively shape the development of renal fibrosis (RF). In this study, we revealed the significance of a signalling axis, circular RNA ACTR2 (circACTR2)/miR-200...
Eleven-month longitudinal study of antibodies in SARS-CoV-2 exposed and naïve primary health care workers upon COVID-19 vaccination [0.03%]
对接触和未接触SARS-CoV-2的医护人员接种新冠疫苗后抗体纵向研究（为期十一月）
Carlota Dobaño,Anna Ramírez-Morros,Selena Alonso et al.
Carlota Dobaño et al.
We evaluated the kinetics of antibody responses to Two years into the COVID-19 pandemic and 1 year after the start of vaccination rollout, the world faced a peak of cases associated with the highly contagious Omicron variant of concern (VoC...
Shimeng Zhou,Jinfeng Zhu,Jingwei Xu et al.
Shimeng Zhou et al.
The immune checkpoint programmed death receptor 1 (PD-1) and programmed death ligand 1 (PD-L1) are biologically important immunosuppressive molecules, and the PD-L1/PD-1-mediated signalling pathway is currently considered one of the main me...
Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three-dose immunization regimen of CoronaVac [0.03%]
风湿病患者生发中心T细胞辅助细胞的动力学及其在新冠疫苗克尔来福三剂免疫程序中的后续抗体应答反应研究
Xingyu Zhou,Yifan Wang,Bo Huang et al.
Xingyu Zhou et al.
Given increased acceptance of the CoronaVac, there is an unmet need to assess the safety and immunogenic changes of CoronaVac in patients with rheumatic diseases (RD). Here we comprehensively analysed humoral and cellular responses in patie...
High density of CD8 T cell and immune imbalance of T lymphocytes subsets are associated with proliferative verrucous leukoplakia [0.03%]
CD8T细胞高密度及T淋巴细胞亚群免疫失衡与增殖性疣状白斑相关性研究
Darcy Fernandes,Camila de Oliveira Barbeiro,Mariana Paravani Palaçon et al.
Darcy Fernandes et al.
Oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL) are oral potentially malignant disorders (OPMDs) that microscopically show no or varying degrees of dysplasia. Even sharing clinical and microscopic aspects, PVL shows a mo...
Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment [0.03%]
IgE受体免疫球蛋白（FCER1G）片段在癌症免疫浸润和肿瘤微环境中的作用
Riwei Yang,Zude Chen,Leqi Liang et al.
Riwei Yang et al.
Although recent studies have revealed the relationship between Fc Fragment of IgE Receptor Ig (FCER1G) and human tumours, there is still a lack of a more comprehensive pan-cancer analysis of FCER1G as an immune-related gene. In this study, ...