MTAP deficiency contributes to immune landscape remodelling and tumour evasion [0.03%]
MTAP缺陷导致免疫景观重塑和肿瘤逃逸
Wen-Hsin Chang,Ssu-Wei Hsu,Jun Zhang et al.
Wen-Hsin Chang et al.
Methylthioadenosine phosphorylase (MTAP) deficiency occurs in various malignancies and is associated with poor survival in cancer patients. However, the mechanisms underlying tumour progression due to MTAP loss are yet to be elucidated. Uti...
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19 [0.03%]
补体系统的替代途径失调在组织中驱动了持续的补体激活并预测了COVID-19全程中的疾病转归
Matthew K Siggins,Kate Davies,Rosie Fellows et al.
Matthew K Siggins et al.
Complement, a critical defence against pathogens, has been implicated as a driver of pathology in COVID-19. Complement activation products are detected in plasma and tissues and complement blockade is considered for therapy. To delineate ro...
The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells [0.03%]
白细胞IL1A基因多态性rs17561的突变与血细胞释放IL-1α减少有关
Kimberley A Wiggins,Katerina Pyrillou,Melanie Humphry et al.
Kimberley A Wiggins et al.
Interleukin-1 alpha (IL-1α) is a powerful cytokine that drives inflammation and modulates adaptive immunity. Due to these powerful effects, IL-1α is controlled at multiple levels from transcription to cleavage and release from the cell. G...
Greg M Delgoffe
Greg M Delgoffe
Editorial
Immunology. 2022 Oct;167(2):123. DOI:10.1111/imm.13576 2022
Tumour necrosis factor plays a deleterious role in the pathogenesis of chikungunya virus infection [0.03%]
肿瘤坏死因子在白喉病毒发病机制中起破坏性作用
Thaiane Pinto Moreira,Carla Daiane Ferreira de Sousa,Victor Rodrigues de Melo Costa et al.
Thaiane Pinto Moreira et al.
Arthralgia is a hallmark of chikungunya virus (CHIKV) infection and can be very debilitating and associated with a robust local inflammatory response. Many pathophysiological aspects associated with the disease remain to be elucidated. Here...
Paleo-immunology of human anti-carbohydrate antibodies preventing primate extinctions [0.03%]
人类抗碳水化合物抗体的古免疫学预防灵长类动物灭绝
Uri Galili
Uri Galili
Two human natural anti-carbohydrate antibodies appeared in critical evolutionary events that brought primates and hominins to brink of extinction. The first is the anti-Gal antibody, produced in Old-World monkeys (OWM), apes and humans. It ...
mTORC1-GLUT1-mediated glucose metabolism drives hyperactivation of B cells in primary Sjogren's syndrome [0.03%]
原发性舍格伦综合征中mTORC1-GLUT1介导的葡萄糖代谢驱动B细胞过度活化
Xuan Luo,Xunyao Wu,Anqi Wang et al.
Xuan Luo et al.
Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by B cell hyperactivation and hypergrammaglobulinemia. Currently, the role of metabolic pathways in the B cells of pSS patients is poorly defined. Here...
BDNF is a prognostic biomarker involved in immune infiltration of lung adenocarcinoma and is associated with brain metastasis [0.03%]
脑 sourceMapping:href=http://db.yunbi.rocks/BMARK10K/term/?id=CL:0000087&source=PheWeb target=_blank亚转移肺腺癌免疫浸润相关生物标志物BDNF的预后价值分析
Qian Yu,Yitian Wang,Guangming Yi et al.
Qian Yu et al.
Non-small cell lung cancer (NSCLC) is one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies, particularly lung adenocarcinoma (LUAD). Brain-derived neurotrophic factor...
Break down the barriers of auto-inflammation: How to deal with a monogenic auto-inflammatory disease and immuno-haematological features in 2022? [0.03%]
打破自炎症的壁垒：单基因自炎症性疾病及免疫/血液学特征如何应对（2022年）
Hélène Vergneault,Capucine Picard,Sophie Georgin-Lavialle
Hélène Vergneault
In the past few years, the spectrum of monogenic systemic auto-inflammatory diseases (MSAID) has widely expanded beyond the typical recurrent fever. Immuno-haematological features, as cytopenias, hypogammaglobulinemia, hypereosinophilia, ly...
Ben Nicholas,Alistair Bailey,Katy J McCann et al.
Ben Nicholas et al.
Oesophageal adenocarcinoma (OAC) has a relatively poor long-term survival and limited treatment options. Promising targets for immunotherapy are short peptide neoantigens containing tumour mutations, presented to cytotoxic T-cells by human ...