Laura Otto Walter,Chandra Chiappin Cardoso,Íris Mattos Santos-Pirath et al.
Laura Otto Walter et al.
Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An adequate T cell response is essential not only for fighting disease but also for the cre...
Daniel Sharygin,Leonidas G Koniaris,Clark Wells et al.
Daniel Sharygin et al.
The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages and monocytes. However, roles for CD14 are incr...
Caspase-6 is a key regulator of cross-talk signal way in PANoptosis in cancer [0.03%]
半胱天冬酶-6在肿瘤PANoptosis交叉信号调控中的关键作用
Ling Qi,Li Wang,Mengru Jin et al.
Ling Qi et al.
Cysteinyl aspartate specific proteinase (caspase)-6 belongs to the caspase family and plays a vital role in mediating cell death. Under certain conditions, three pathways of programmed cell death (PCD), including apoptosis, necroptosis and ...
DNA methylation trajectories during innate and adaptive immune responses of human B lymphocytes [0.03%]
人B淋巴细胞在固有和适应性免疫反应过程中的DNA甲基化轨迹
Kai Fu Jhuang,Man Lun Hsu,Yu-Chia Chen et al.
Kai Fu Jhuang et al.
B lymphocytes can engage in either a rapid T cell-independent pathway (TI) or a delayed long-lasting T cell-independent (TD) response through highly ordered transcriptional programs, yet the detailed underlying mechanisms are unclear. Since...
The turning point of COVID-19 severity is associated with a unique circulating neutrophil gene signature [0.03%]
COVID-19重症拐点与独特的循环中性粒细胞基因特征有关
Carlos A Fuzo,Thais F C Fraga-Silva,Sandra R Maruyama et al.
Carlos A Fuzo et al.
COVID-19 has a broad spectrum of clinical manifestations associated with the host immune response heterogeneity. Despite the advances in COVID-19 research, it is still crucial to seek a panel of molecular markers that enable accurate strati...
Sushmita Chakraborty,Jakob Schneider,Dipendra Kumar Mitra et al.
Sushmita Chakraborty et al.
Interleukin (IL)-9 is an emerging player in the pathogenesis of various chronic inflammatory diseases including bone disorders like rheumatoid arthritis (RA) and psoriatic arthritis. Recently, IL-9 was shown to enhance the osteoclast format...
Dual blockages of a broad and potent neutralizing IgM antibody targeting GH loop of EV-As [0.03%]
针对EV-As病毒GH环的广谱强效中和性IgM抗体Dual-blockage研究
Wenbing Zhu,Jun Li,Zhongxiang Wu et al.
Wenbing Zhu et al.
The reported enterovirus A 71 (EVA71) vaccines and immunoglobin G (IgG) antibodies have no cross-antiviral efficacy against other enterovirus A (EV-A) which caused hand, foot and mouth disease (HFMD). Here we constructed an IgM antibody (20...
Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming [0.03%]
线粒体丙酮酸载体失活通过代谢重编促进NLRP3炎性小体活化和痛风发病
Lih-Chyang Chen,Yu-Jen Chen,Hsin-An Lin et al.
Lih-Chyang Chen et al.
The nucleotide-binding and oligomerization domain, leucine-rich repeats, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a crucial role in innate immunity and is involved in the pathogenesis of autoinflammatory diseases. Gl...
Systemic immune mediators reflect tumour-infiltrating lymphocyte intensity and predict therapeutic response in triple-negative breast cancer [0.03%]
系统性免疫介质反映三阴乳腺癌肿瘤浸润淋巴细胞强度并可预测治疗反应
Ananda D Lopes,Nayane A L Galdino,Amanda B Figueiredo et al.
Ananda D Lopes et al.
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer (BC). Neoadjuvant chemotherapy has proven efficacy in its treatment, and a pathological complete response (pCR) to therapy is predictive of improved long-term survi...
New role of gramicidin A in RIG-I-like receptors-mediated IFN signalling [0.03%]
Gramicidin A在RIG-I样受体介导的IFN信号中的新作用
Xiao Li,Xinyuan Sun,Zhongyi Yan et al.
Xiao Li et al.
The pattern recognition receptors (PRRs) sense exogenous molecular patterns most commonly derived from invading pathogens, to active the interferon (IFN) signalling. In the cytoplasm, the viral double-stranded RNAs (dsRNAs) are sensed by re...