Multi-omic and spatial dissection of immunotherapy response groups in non-small cell lung cancer [0.03%]
非小细胞肺癌免疫治疗反应组的多组学和空间解析
James Monkman,Honesty Kim,Aaron Mayer et al.
James Monkman et al.
The composition and activation status of the cellular milieu contained within the tumour microenvironment (TME) is becoming increasingly recognized as a driving factor for immunotherapy response. Here, we employed multiplex immunohistochemi...
Burnout in science [0.03%]
科学研究中的职业倦怠感
Greg M Delgoffe
Greg M Delgoffe
Editorial
Immunology. 2023 May;169(1):1-2. DOI:10.1111/imm.13639 2023
IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice [0.03%]
IL-1β促进小鼠ILC3细胞产生IL-17A加重中性粒细胞性气道炎症
Dan Yang,Yi&#x;na Li,Ting Liu et al.
Dan Yang et al.
IL-17A-producing group 3 innate lymphoid cells (ILC3s) have been found to participate in the development of various phenotypes of asthma, however, little is known about how ILC3s mediate neutrophilic airway inflammation. Elevated IL-1β has...
Development of novel self-assembled vaccines based on tumour-specific antigenic peptide and TLR2 agonist for effective breast cancer immunotherapy via activating CD8+ T cells and enhancing their function [0.03%]
基于肿瘤特异性抗原肽和TLR2激动剂的新型自组装疫苗通过激活CD8+t细胞并增强其功能促进有效乳腺癌免疫治疗的发展
Wei Shi,Zhenzhen Tong,Shuang Chen et al.
Wei Shi et al.
Vaccines based on tumour-specific antigens are a promising approach for immunotherapy. However, the clinical efficacy of tumour-specific antigens is still challenging. Twelve conjugates with self-assembly properties were designed and synthe...
T-cell exhaustion in CAR-T-cell therapy and strategies to overcome it [0.03%]
CAR-T细胞治疗中的T细胞耗竭及其应对策略
Xuechen Yin,Lingfeng He,Zhigang Guo
Xuechen Yin
Tumour immunotherapy has achieved good therapeutic effects in clinical practice and has received increased attention. Cytotoxic T cells undoubtedly play an important role in tumour immunotherapy. As a revolutionary tumour immunotherapy appr...
CD226 deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene-induced atopic dermatitis [0.03%]
CD226缺陷通过加重硝氯苯诱导的小鼠特应性皮炎中的肠道免疫紊乱促进疾病发生发展
Tingting Wang,Wei Qiao,Yang Xie et al.
Tingting Wang et al.
Intestinal mucosal immunity plays a pivotal role in host defence. In this study, we found that cluster of differentiation 226 (CD226) gene knockout (KO) led to more severe atopic dermatitis (AD)-related skin pathologies and bowel abnormalit...
AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway [0.03%]
活化 AhR 通过 Skp2/K63 泛素化途径增强 Lkb1 介导的脂肪酸氧化促进 Treg 细胞生成
Qin Zhang,Yanrong Zhu,Changjun Lv et al.
Qin Zhang et al.
Several aryl hydrocarbon receptor (AhR) agonists have been reported to promote the generation of regulatory T cells (Treg cells), and the action mechanisms need to be identified. In this study, we addressed the underlying mechanism of AhR a...
TCR-Pred: A new web-application for prediction of epitope and MHC specificity for CDR3 TCR sequences using molecular fragment descriptors [0.03%]
TCR-Pred：一种使用分子片段描述符预测表位和MHC特异性的新型网络应用程序，用于CDR3 TCR序列
Anton S Smirnov,Anastasia V Rudik,Dmitry A Filimonov et al.
Anton S Smirnov et al.
The search for the relationships between CDR3 TCR sequences and epitopes or MHC types is a challenging task in modern immunology. We propose a new approach to develop the classification models of structure-activity relationships (SAR) using...
Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNβ production [0.03%]
Pellino3连接酶通过下调TRAF3介导的转录因子IRF3和IFNβ诱导抑制流感B依赖型RIG-I信号通路
Anna Kula,Edyta Makuch,Marta Lisowska et al.
Anna Kula et al.
Viral infection activates the innate immune system, which recognizes viral components by a variety of pattern recognition receptors and initiates signalling cascades leading to the production of pro-inflammatory cytokines. To date, signalli...
Yin Yao,Yiyin Hu,Fei Wang
Yin Yao
Despite the clinical success of monoclonal and bispecific antibodies, there are still limitations in the therapeutic effect of malignant tumours, such as low response rate, treatment resistance, and so on, inspiring the exploration of trisp...