Activation of Inflammasome complex in nasopharyngeal epithelial cells from patients with Coronavirus disease 2019 contributes to inflammatory state and worse disease outcomes [0.03%]
新冠病毒感染患者鼻咽上皮细胞炎性小体激活加重炎症反应及病情恶化
Zahra Bagheri-Hosseinabadi,Mohsen Dehghan-Banadaki,Gholamhossein Taghipour Khaje Sharifi et al.
Zahra Bagheri-Hosseinabadi et al.
Pathogenesis of Coronavirus disease 2019 (COVID-19) has been associated with dysregulation of both adaptive and innate immune systems. Hence, we determined the contribution of inflammasome in the nasopharyngeal epithelial cells isolated fro...
Autoantigen-selected B cells are bystanders in spontaneous T cell-driven experimental autoimmune hepatitis [0.03%]
自身抗原选择的B细胞是自发性的T细胞驱动的实验性自身免疫性肝炎的旁观者
David Lübbering,Max Preti,Lena Schlott et al.
David Lübbering et al.
Autoreactive B cells are considered pathogenic drivers in many autoimmune diseases; however, it is not clear whether autoimmune B cells are invariably pathogenic or whether they can also arise as bystanders of T cell-driven autoimmune patho...
Samer Kareem,Alexander Jacob,John Mathew et al.
Samer Kareem et al.
The complement system, an arm of the innate immune system plays a critical role in both health and disease. The complement system is highly complex with dual possibilities, helping or hurting the host, depending on the location and local mi...
Monocyte pathology in human tuberculosis is due to plasma milieu changes and aberrant STAT signalling [0.03%]
人类结核病单核细胞病理改变由血浆微环境变化和STAT信号异常引起
Hubert Senanu Ahor,Rebecca Schulte,Ernest Adankwah et al.
Hubert Senanu Ahor et al.
Monocyte-derived macrophages contribute centrally to immune protection in Mycobacterium tuberculosis infection and changes in monocyte phenotype characterize immunopathology in tuberculosis patients. Recent studies highlighted an important ...
Inhibiting N-glycan processing increases the antibody binding affinity and effector function of human natural killer cells [0.03%]
N-糖链加工抑制可增加人自然杀伤细胞的抗体结合亲和力和效应功能
Maria Carolina Rodriguez Benavente,Harrison B Hughes,Paul G Kremer et al.
Maria Carolina Rodriguez Benavente et al.
Novel approaches are required to improve the efficacy of immunotherapies and increase the proportion of patients who experience a benefit. Antibody-dependent cell-mediated cytotoxicity (ADCC) contributes to the efficacy of many monoclonal a...
EPOR activation attenuates colitis via enhancing LC3B-dependent apoptotic cell clearance [0.03%]
激活EPOR通过增强LC3B依赖的凋亡细胞清除来减轻结肠炎
Xue Liu,Ling-Yuan Zhang,Yu-Ge Zhang et al.
Xue Liu et al.
Systemic immune activation and excessive inflammatory response, induced by intestinal barrier damage, are the major characteristics of inflammatory bowel disease (IBD). Excessive apoptotic cell accumulation leads to the production of a larg...
Ability of SpikoGen®, an Advax-CpG adjuvanted recombinant spike protein vaccine, to induce cross-neutralising antibodies against SARS-CoV-2 variants [0.03%]
SpikoGen®诱导针对SARS-CoV-2变异株的交叉中和抗体的能力研究：一种Advax-CpG佐剂型重组刺突蛋白疫苗
Yoshikazu Honda-Okubo,Anna Antipov,Greiciely Andre et al.
Yoshikazu Honda-Okubo et al.
SpikoGen® vaccine is a subunit COVID-19 vaccine expressed in insect cells comprising recombinant spike protein extracellular domain formulated with Advax-CpG55.2™ adjuvant. A Phase 2 trial was conducted in 400 adult participants randomise...
Clinical Trial
Immunology. 2023 Oct;170(2):193-201. DOI:10.1111/imm.13661 2023
Staphylococcus aureus biofilm properties and chronic rhinosinusitis severity scores correlate positively with total CD4+ T-cell frequencies and inversely with its Th1, Th17 and regulatory cell frequencies [0.03%]
金黄色葡萄球菌生物膜特性和慢性鼻窦炎严重程度评分与总CD4⁺T细胞频率呈正相关，而与其Th1、Th17和调节性细胞频率呈负相关
Gohar Shaghayegh,Clare Cooksley,George Bouras et al.
Gohar Shaghayegh et al.
Chronic rhinosinusitis (CRS) represents chronic inflammation of the sinus mucosa characterised by dysfunction of the sinuses' natural defence mechanisms and induction of different inflammatory pathways ranging from a Th1 to a Th2 predominan...
Screening and anti-glioma activity of Chiloscyllium plagiosum anti-human IL-13Rα2 single-domain antibody [0.03%]
基于斑点吻刺虾虎鱼抗人IL-13Rα2单域抗体的筛选及其抗胶质瘤活性研究
Lanyi Qin,Qingyu Ren,Chaoling Lu et al.
Lanyi Qin et al.
Glioblastoma is a common and fatal malignant tumour of the central nervous system, with high invasiveness. Conventional treatments for this disease, including comprehensive treatment of surgical resection combined with chemoradiotherapy, ar...
Prevalence of salivary anti-SARS-CoV-2 IgG antibodies in vaccinated children [0.03%]
接种疫苗儿童口水中抗SARS-CoV-2免疫球蛋白G抗体的流行率
María Noel Badano,Alejandra Duarte,Gabriela Salamone et al.
María Noel Badano et al.