Maria Mulet,Ruben Osuna-Gómez,Carlos Zamora et al.
Maria Mulet et al.
The migration and antimicrobial functions of neutrophils seem to be impaired during sepsis and contribute to the dysregulation of immune responses and disease pathogenesis. However, the role of neutrophil extracellular traps (NETs) remains ...
PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity [0.03%]
PKCζ活化促进脐带血T细胞向Th1 IFN-γ倾向成熟
Khalida Perveen,Alex Quach,Michael J Stark et al.
Khalida Perveen et al.
A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells (CBTC), associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a hig...
βhCG mediates immune suppression through upregulation of CD11b+ Gr1+ myeloid derived suppressor cells, CD206+ M2 macrophages, and CD4+ FOXP3+ regulatory T-cells in BRCA1 deficient breast cancers [0.03%]
BRCA1缺陷型乳腺癌中，βhCG通过上调CD11b+Gr1+髓源性抑制细胞、CD206+M2巨噬细胞和CD4+FOXP3+调节性T细胞介导免疫抑制作用
Geetu Rose Varghese,Dipyaman Patra,Vishnu Sunil Jaikumar et al.
Geetu Rose Varghese et al.
BRCA1 mutation is reported in about 70% of all triple negative breast cancers (TNBC), while BRCA1 defect due to promoter hypermethylation is seen in about 30%-60% of sporadic breast cancers. Although PARP inhibitors and platinum-based chemo...
Polymorphonuclear myeloid-derived suppressor cells play a proinflammatory role via TNF-α+ B cells through BAFF/BTK/NF-κB signalling pathway in the pathogenesis of collagen-induced arthritis mice [0.03%]
多形核髓系来源抑制性细胞通过TNF-α+B细胞在胶原诱导的关节炎小鼠发病机制中发挥促炎症作用：BAFF/BTK/NF-κB信号通路参与
Mei Li,Zhicheng Tang,Ruilu Shu et al.
Mei Li et al.
Although various studies have been performed on the function of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in RA, the results were conflicting. Here we were trying to clarify the role of PMN-MDSCs in the pathogenesis of ...
Malignancy-associated immune responses: Lessons from human inborn errors of immunity [0.03%]
肿瘤相关免疫反应：来自人类先天性免疫缺陷的启示
Agnel Aliyath,Ayolola Eni-Olotu,Niamh Donaldson et al.
Agnel Aliyath et al.
It is widely understood that cancer is a significant cause of morbidity and mortality worldwide. Despite numerous available treatments, prognosis for many remains poor, thus, the development of novel therapies remains essential. Given the i...
Effect of gut flora mediated-bile acid metabolism on intestinal immune microenvironment [0.03%]
肠道菌群介导的胆汁酸代谢对肠粘膜免疫微环境的影响
Yan Zhang,Xueyan Gao,Shuochen Gao et al.
Yan Zhang et al.
According to reports, gut microbiota and metabolites regulate the intestinal immune microenvironment. In recent years, an increasing number of studies reported that bile acids (BAs) of intestinal flora origin affect T helper cells and regul...
Comparison of culture media reveals that non-essential amino acids strongly affect the phenotype of human monocyte-derived macrophages [0.03%]
不同培养基比较显示非必需氨基酸强烈影响人单核细胞源巨噬细胞的表型
Kristian W Antonsen,Henriette N Friis,Boe S Sorensen et al.
Kristian W Antonsen et al.
Macrophages are important innate immune cells with the ability to adapt their phenotype to environmental cues. Research on human macrophages often uses monocyte-derived macrophages cultured in vitro, but it is unclear if culture medium affe...
TLR3/TRIF pathway confers protection against herpes simplex encephalitis through NK cell activation mediated by a loop of type I IFN and IL-15 from epithelial and dendritic cells [0.03%]
toll样受体3/trif途径通过上皮细胞和树突状细胞产生的一类i型干扰素和il-15的循环激活自然杀伤细胞来预防单纯疱疹病毒脑炎
Erdenebileg Uyangaa,Jin Young Choi,Seong Ok Park et al.
Erdenebileg Uyangaa et al.
Autosomal recessive (AR) and dominant (AD) deficiencies of TLR3 and TRIF are believed to be crucial genetic causes of herpes simplex encephalitis (HSE), which is a fatal disease causing focal or global cerebral dysfunction following infecti...
6-Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD-1 to inhibit PD-1 signalling and enhance T cell function [0.03%]
6-巯基嘌呤通过抑制PD-1信号传导和增强T细胞功能来强力抑制磷酸化PD-1的SHP2募集
Lu Liu,Yuxi Lei,Zongyao Zheng et al.
Lu Liu et al.
Antibody inhibitors that block PD-1/PD-L1 interaction have been approved for oncological clinics, yielding impressive treatment effects. Small molecules inhibiting PD-1 signalling are at various stages of development, given that small molec...
DACH1 regulates macrophage activation and tumour progression in hypopharyngeal squamous cell carcinoma [0.03%]
DACH1调节低咽鳞状细胞癌巨噬细胞活化和肿瘤进展
Wenjing Li,Licheng Xu,Jing Cao et al.
Wenjing Li et al.
Dachshund family transcription factor 1 (DACH1) has been shown to exhibit a tumour-suppressive role in a number of human cancers. However, the role of DACH1 in hypopharyngeal squamous cell carcinoma (HPSCC) and its function in the tumour mi...