Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis [0.03%]
巨噬细胞内脂质积累损害T细胞反应并影响内脏利什曼病的药物治疗效果
Marta Araújo,Diana Moreira,Inês Mesquita et al.
Marta Araújo et al.
Under perturbing conditions such as infection with Leishmania, a protozoan parasite living within the phagosomes in mammalian macrophages, cellular and organellar structures, and metabolism are dynamically regulated for neutralizing the pre...
A robust platform for integrative spatial multi-omics analysis to map immune responses to SARS-CoV-2 infection in lung tissues [0.03%]
一个鲁棒的平台，用于集成空间多组学分析，以映射SARS-CoV-2感染对肺组织免疫反应的影响
Xiao Tan,Laura F Grice,Minh Tran et al.
Xiao Tan et al.
The SARS-CoV-2 (COVID-19) virus has caused a devastating global pandemic of respiratory illness. To understand viral pathogenesis, methods are available for studying dissociated cells in blood, nasal samples, bronchoalveolar lavage fluid an...
TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice [0.03%]
TRAFFICKING MOLECULE 5通过RUNX1调节结肠炎小鼠肠道黏膜Tʜ1/Tʜ17细胞免疫应答
Mengting Li,Caiqin Gan,Runan Zhang et al.
Mengting Li et al.
Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disease associated with CD4+ Th1 and Th17 cell immune responses. Tumour necrosis factor-associated factor 5 (TRAF5) deficiency has been shown to aggravate DSS-induc...
Inhibition of PI3K p110δ activity reduces IgE production in IL-4 and anti-CD40 stimulated human B cell cultures [0.03%]
PI3K p110δ活性抑制可降低白细胞介素4和抗CD40刺激的人B细胞培养物中的IgE产生量
Anna Cutrina-Pons,Aloka De Sa,David J Fear et al.
Anna Cutrina-Pons et al.
Phosphoinositide 3-kinase (PI3K) p110δ signalling negatively regulates the production of mouse IgE. However, there are disparities between the mouse and human IgE biology, and the role of PI3K p110δ in the production of human IgE is yet t...
Deubiquitinase inhibitor PR-619 potentiates colon cancer immunotherapy by inducing ferroptosis [0.03%]
去泛素酶抑制剂PR-619通过诱导铁死亡增强结直肠癌免疫治疗
Jingjing Wu,Chang Liu,Tao Wang et al.
Jingjing Wu et al.
A substantial number of colon cancer patients do not benefit from immunotherapy using programmed cell death 1 (PD1) antibodies. Therefore, combination therapy drugs are required to improve the efficacy of colon cancer immunotherapy. Recent ...
FEN1 inhibitor SC13 promotes CAR-T cells infiltration into solid tumours through cGAS-STING signalling pathway [0.03%]
FEN1抑制剂SC13通过cGAS-STING信号通路促进CAR-T细胞向实体瘤浸润
Yunfei Dong,Yuanyuan Wang,Xuechen Yin et al.
Yunfei Dong et al.
It is well known that chimeric antigen receptor T-cell immunotherapy (CAR-T-cell immunotherapy) has excellent therapeutic effect in haematological tumours, but it still faces great challenges in solid tumours, including inefficient T-cell t...
Cortisol synergizing with endoplasmic reticulum stress induces regulatory T-cell dysfunction [0.03%]
应激诱导的调节性T细胞功能障碍及其机制研究
Jiangping Luo,Caijie Zhou,Shiqi Wang et al.
Jiangping Luo et al.
The dysfunction of regulatory T cell (Treg) is associated with the pathogenesis of many immune diseases. The regiments used to re-establish Treg's function are currently unsatisfactory and need to be improved. The purpose of this study is t...
Targeting PI3Kα increases the efficacy of anti-PD-1 antibody in cervical cancer [0.03%]
PI3Kα抑制能增强抗PD-1抗体在宫颈癌治疗中的疗效
Wei Jiang,Xueyan Ouyang,Chunyan Li et al.
Wei Jiang et al.
Targeting programmed death 1(PD-1) has been approved for relapsed cervical cancer with unsatisfactory clinical efficacy. This study aims to analyse the impact of PI3K pathway activation on tumour immune microenvironment and evaluates the im...
cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases [0.03%]
cAMP响应元件调节剂α促进系统性自身免疫病中效应T细胞的形成
Emil Carlsson,Taylor Cowell-McGlory,Christian M Hedrich
Emil Carlsson
T lymphocytes play a crucial role in adaptive immunity. Dysregulation of T cell-derived inflammatory cytokine expression and loss of self-tolerance promote inflammation and tissue damage in several autoimmune/inflammatory diseases, includin...
Dengqiang Wu,Yujie Li
Dengqiang Wu
Hepatocellular carcinoma (HCC) remains a global health challenge. Novel treatment modalities are urgently needed to extend the overall survival of patients. The liver plays an immunomodulatory function due to its unique physiological struct...