Transforming growth factor-β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis [0.03%]
转化生长因子-β、白介素-23和白介素-1β调节多药耐药结核病活动期的TH22应答
Belén R Imperiale,Ana Gamberale,Noemí Yokobori et al.
Belén R Imperiale et al.
We previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could infl...
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics [0.03%]
尼帕病毒治疗新进展：疫苗、抗病毒和药物疗法的现状分析
Gayatree Mishra,Vishal Prajapat,Debasis Nayak
Gayatree Mishra
Nipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-...
Macrophage memory: Types, mechanisms, and its role in health and disease [0.03%]
巨噬细胞记忆：类型、机制及其在健康和疾病中的作用
Xu-Hui Fang,Zhi-Jing Li,Chun-Yan Liu et al.
Xu-Hui Fang et al.
On the basis of the mechanisms of action and characteristics of immune effects, immunity is commonly categorized into innate and adaptive immunity. Adaptive immunity is associated with the response to non-self-entities and is characterized ...
Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients [0.03%]
维生素D缺乏与HBV感染患者γδT细胞衰竭的风险增加有关
Ke Li,Eying Lu,Qian Wang et al.
Ke Li et al.
Previous studies have demonstrated that T cell exhaustion is associated with poor clearance of Hepatitis B virus (HBV). However, whether the expression of exhaustion markers on innate-like circulating γδ T cells derived from patients with...
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis [0.03%]
SKG类风湿关节炎小鼠模型中B淋巴细胞发育的失调
Joo Eun June Kim,Lin Tze Tung,Roselyn R Jiang et al.
Joo Eun June Kim et al.
Rheumatoid arthritis is a chronic and systemic inflammatory disease that affects approximately 1% of the world's population and is characterised by joint inflammation, the destruction of articular cartilage and bone, and many potentially li...
Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock [0.03%]
Flot2缺陷促进B细胞介导的炎症反应和内毒素休克
Qin Yang,Zhenhua Zhang,Ziye Chen et al.
Qin Yang et al.
Sepsis is a life-threatening disease characterized by multiple organ dysfunction. B cells play a pivotal role in sepsis. Here, we first observed the significantly reduced Flot2 gene expression in B cells from patients with bacterial sepsis ...
Hayder M Al-Kuraishy,Ali K Albuhadily,Ali I Al-Gareeb et al.
Hayder M Al-Kuraishy et al.
Interleukin-7 improves the fitness of regulatory T cells for adoptive transfer [0.03%]
白细胞介素-7能提高供体调节性T细胞的转移能力
Ilaria Cosorich,Jessica Filoni,Carla Di Dedda et al.
Ilaria Cosorich et al.
Adoptive regulatory T-cell (Treg) transfer has emerged as a promising therapeutic strategy for regulating immune responses in organ transplantation, graft versus host disease, and autoimmunity, including Type 1 diabetes. Traditionally, Treg...
Ziwen Qin,Yujuan Chen,Yue Wang et al.
Ziwen Qin et al.
Bronchial asthma is a heterogeneous disease characterised by chronic airway inflammation. A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells are involved in the airway inflammat...
Ceftazidime reduces cellular Skp2 to promote type-I interferon activity [0.03%]
头孢他啶通过降低细胞Skp2水平来促进I型干扰素活性
Caixia Qiao,Fan Huang,Jiuyi He et al.
Caixia Qiao et al.
Skp2 plays multiple roles in malignant tumours. Here, we revealed that Skp2 negatively regulates type-I interferon (IFN-I)-mediated antiviral activity. We first noticed that Skp2 can promote virus infection in cells. Further studies demonst...