Mitochondrial Activity Regulates Human T Helper 17 Differentiation and Function [0.03%]
线粒体活性调节人T辅助17的分化和功能
Xinlai Chen,Theodoros Ioannis Papadimitriou,Anne H G van Essen et al.
Xinlai Chen et al.
Immunometabolism plays a pivotal role in T cell fate decisions, yet its specific contribution to human Th17 differentiation remains incompletely understood. Th17 cells, a subset of CD4+ T cells, are central to autoimmune pathogenesis throug...
5-FU Resistance Facilitates Immune Evasion in Esophageal Squamous Cell Carcinoma Through ADAM10-Mediated PD-L1 Shedding and Tumour Microenvironment Remodelling [0.03%]
耐5-氟尿嘧啶的食管鳞状细胞癌通过ADAM10介导的PD-L1脱落和肿瘤微环境重塑促进免疫逃逸
Bangwu Cai,Xiaowen Feng,Shujuan Luo et al.
Bangwu Cai et al.
Chemoresistance remains a major challenge in esophageal squamous cell carcinoma (ESCC) therapy, particularly resistance to 5-Fluorouracil (5-FU). This study uncovers how 5-FU resistance reprograms the tumour microenvironment, primarily thro...
The Immune System and Cellular Senescence: A Complex Interplay in Aging and Disease [0.03%]
免疫系统与细胞衰老：在衰老和疾病中的复杂相互作用
Marc Ayoub,Chris Abou Jaoude,Mohamad Ayoub et al.
Marc Ayoub et al.
Immunosenescence is the process of immune dysfunction and gradual deterioration of the immune system associated with aging, while cellular senescence is the stable cell cycle arrest that can occur in non-immune or immune cells in response t...
Review
Immunology. 2025 Sep 12. DOI:10.1111/imm.70036 2025
Enolase-1 Is a Key Regulator of Neutrophil Recruitment During Acute Inflammation [0.03%]
烯醇化酶-1是急性炎症中性粒细胞募集的关键调节因子
Hsueh-Yen Lu,Ping-Hsiang Huang,Ting-Wei Lee et al.
Hsueh-Yen Lu et al.
Enolase-1 (ENO1) is a moonlighting protein with multiple functions. When expressed on the cell surface, ENO1 binds plasminogen (PLG) and promotes cell migration by facilitating plasmin (PLM)-mediated extracellular matrix degradation. Here, ...
COX-2 Mediates Immune Evasion and Decreases Chemosensitivity in Breast Cancer Through Activation of the JAK2/STAT3 Signalling Pathway [0.03%]
环氧合酶2通过活化JAK2/STAT3信号通路介导免疫逃逸并降低乳腺癌的化疗敏感性
Guohua Liu,Peng Liu,Kai Liang et al.
Guohua Liu et al.
With 1 in every 20 women afflicted, breast cancer is the most frequent malignant tumour in women and a significant health burden on women. Drug resistance in cancer is the key problem limiting current therapy approaches. Cyclooxygenase-2 (C...
Microneedle-Delivered Multivalent MPXV DNA Vaccines Induce Promising Immunity Profiles and Cross-Protection in Mice [0.03%]
微针递送的MPXV多价DNA疫苗可诱导小鼠产生良好的免疫反应并提供交叉保护
Yawei Wang,Xueting Cheng,Baoying Huang et al.
Yawei Wang et al.
Traditional DNA vaccines, typically administered via intramuscular injection with electroporation (IM-E), often cause discomfort and require trained personnel. Addressing these challenges, we developed multivalent DNA vaccines targeting bot...
Dendritic Cell-Derived Extracellular Vesicles as Therapeutic Cancer Vaccines: Mechanisms and Optimization Strategies [0.03%]
树突状细胞来源的外泌体作为治疗性癌症疫苗：机制和优化策略
Jonathan Shpigelman,Krishna Rao
Jonathan Shpigelman
Extracellular vesicles (EVs) are ubiquitously secreted nanoparticles that modulate the activities of recipient cells either through the transfer of bioactive cargo or by surface receptor-mediated signalling. EVs derived from dendritic cells...
Review
Immunology. 2025 Sep 2. DOI:10.1111/imm.70033 2025
Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in Mice [0.03%]
脆弱拟杆菌通过抑制黏蛋白产生和改变菌群组成促进小鼠1型糖尿病发病加速
Radhika R Gudi,Harrison Taylor,Benjamin M Johnson et al.
Radhika R Gudi et al.
Type 1 diabetes (T1D) in humans is associated with a higher Bacteroidetes:Firmicutes ratio and a higher abundance of Bacteroides genus members. Bacteroides fragilis (BF) is an integral component of the human colonic commensal microbiota. He...
Tertiary Lymphoid Structures Predict Prognosis and Immune Checkpoint Inhibitor Efficacy in Lung Squamous Cell Carcinoma [0.03%]
结节性淋巴样组织能预测肺鳞状细胞癌的预后和免疫检查点抑制剂的效果
Kuifei Chen,Suna Zhou,Pin Zhou et al.
Kuifei Chen et al.
Lung squamous cell carcinoma (LUSC) is a highly mortal cancer. Tertiary lymphoid structures (TLSs) play a crucial role in creating a specific and essential environment for the development of cellular and humoral immune responses against tum...