CD57 T cells associated with immunosenescence in adults living with HIV or AIDS [0.03%]
与HIV/AIDS成人患者免疫衰老相关的CD57 T细胞
Erivaldo Elias Junior,Vanessa T Gubert,Camila M Bonin-Jacob et al.
Erivaldo Elias Junior et al.
Despite the advancement of human immunodeficiency virus (HIV)-related discoveries, new HIV infections still persist. With the advent of antiretroviral therapy, prognosis has migrated from acute to chronic HIV infection and inflammation, wit...
Structure-guided discovery of aminopeptidase ERAP1 variants capable of processing antigens with novel PC anchor specificities [0.03%]
基于结构的发现具有新型PC锚特异性的抗原加工氨基肽酶ERAP1变异体
Suchita Pande,Hwai-Chen Guo
Suchita Pande
Endoplasmic reticulum aminopeptidase 1 (ERAP1) belongs to the oxytocinase subfamily of M1 aminopeptidases (M1APs), which are a diverse family of metalloenzymes involved in a wide range of functions and have been implicated in various chroni...
The alterations of innate immunity and enhanced severity of infections in diabetes mellitus [0.03%]
糖尿病患者先天性免疫的变化和感染加重的趋势
Zi Zhou,Hao Wang,Sipin Tan et al.
Zi Zhou et al.
Diabetes mellitus (DM) is a metabolic inflammatory disease with a high incidence worldwide. Patients with DM are at a high risk for all types of infections. Type 1 DM is characterised with immune destruction of pancreatic β cells, while ty...
Leishmania surface molecule lipophosphoglycan-TLR2 interaction moderates TPL2-mediated TLR2 signalling for parasite survival [0.03%]
利什曼原虫表面分子脂磷酸糖- Toll 样受体 2 相互作用调节促分裂原活化蛋白激酶激酶 8介导的 Toll 样受体 2信号通路以促进寄生虫存活
Soumya Kanti Ghosh,Divanshu Shukla,Hima Mahor et al.
Soumya Kanti Ghosh et al.
Leishmania donovani, a protozoan parasite, resides and replicates in macrophages and inflicts the potentially fatal disease visceral leishmaniasis (VL). The parasite-expressed surface lipophosphoglycan (LPG) was implicated in binding TLR2 o...
Secondary Streptococcus pneumoniae infection increases morbidity and mortality during murine cryptococcosis [0.03%]
肺炎链球菌二次感染增加小鼠隐球菌病的发病率和死亡率
Bárbara A Miranda,Gustavo J C Freitas,Victor A T Leocádio et al.
Bárbara A Miranda et al.
Microorganisms that cause pneumonia and translocate to the central nervous system (CNS) are responsible for high mortality worldwide. The fungus Cryptococcus gattii (Cg) and the bacteria Streptococcus pneumoniae (Sp) target the same infecti...
Unlocking the role of the B7-H4 polymorphism in psoriasis: Insights into methotrexate treatment outcomes: A prospective cohort study [0.03%]
B7-H4多态性在银屑病中的作用及与甲氨蝶呤疗效关系的前瞻性队列研究
Bing Wang,Zhicheng Wang,Wenjing Yang et al.
Bing Wang et al.
B7-H4 is a recently discovered member of B7 family that negatively regulates T-cell immunity, specifically Th1 and Th17 cell responses. However, its role in the pathogenesis of psoriasis has yet to be determined. This study aims to investig...
Piet C de Groen
Piet C de Groen
The aetiology of type 1 diabetes (T1D) is considered multifactorial with the contribution of the MHC on chromosome 6 being most important. Multiple factors also contribute to the aetiology of colorectal neoplasia, but the final event causin...
Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell-mediated immune surveillance [0.03%]
TRIM30a通过抑制蛋白质量控制系统使肿瘤细胞对NK细胞介导的免疫监视更加敏感
Lukman O Afolabi,Jiacheng Bi,Liang Chen et al.
Lukman O Afolabi et al.
Tumorigenesis entails circumventing cell-intrinsic regulatory mechanisms while avoiding extrinsic immune surveillance and other host defence systems. Nevertheless, how tumour cells' ability to eliminate misfolded proteins affects immune sur...
Tongtong Zhang,Fei Xing,Mingcui Qu et al.
Tongtong Zhang et al.
NLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' funct...