Correlation between antibodies against the pathogenic pHERV-W envelope protein and the inflammatory phase of multiple sclerosis [0.03%]
针对病原性pHERV-W包膜蛋白的抗体与多发性硬化症炎症期的相关性研究
Stefano Ruberto,Davide Cossu,Leonardo A Sechi
Stefano Ruberto
The role of retroviral envelope proteins belonging to the Human Endogenous Retroviral family 'W' (HERV-W), specifically syncytin-1 and pathogenic HERV-W (pHERV-W), as potential risk factors in multiple sclerosis (MS) has been established. T...
Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis [0.03%]
调节性T细胞可防止不变自然杀伤T细胞介导的自身免疫结肠炎和肝炎
Koen Venken,Tine Decruy,Tim Sparwasser et al.
Koen Venken et al.
Immunomodulatory T cells play a pivotal role in protection against (auto)immune-mediated diseases that open perspectives for therapeutic modulation. However, how immune regulatory networks operate in vivo is less understood. To this end, we...
Macrophage-like rapid uptake and toxicity of tattoo ink in human monocytes [0.03%]
纹身墨水中的颜料可在人体单核细胞中快速被吸收并产生毒性
Cheng Lin,Yvonne Marquardt,Stefan Rütten et al.
Cheng Lin et al.
Macrophages play a critical role for the persistence of tattoo ink in human skin. However, a comparison to other skin-resident and blood circulating immune cells and a profound analysis of REACH-compliant tattoo ink are unmet medical needs....
Intratracheal administration of cross-linked water-soluble acrylic acid polymer is associated with inducible bronchi-related lymphoid tissue formation and allergic inflammation [0.03%]
交联的水溶性丙烯酸聚合物气管内给药与诱导支气管相关淋巴组织形成和过敏炎症有关
Takamasa Kido,Chiemi Sugaya,Hiroshi Hano et al.
Takamasa Kido et al.
In a Japanese chemical factory, lung diseases such as pneumoconiosis have been reported among workers handling cross-linked water-soluble acrylic acid polymers (CWAAP). Our previous study reported that a single intratracheal administration ...
Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin-1 downregulation [0.03%]
岩藻糖化缺陷脾细胞通过下调血小板源性生长因子促进T细胞增殖和分化
Jung Hwa Ko,Jin Suk Ryu,Jang-Hee Oh et al.
Jung Hwa Ko et al.
Fucosylation plays a critical role in cell-to-cell interactions and disease progression. However, the effects of fucosylation on splenocytes and their interactions with T cells remain unclear. In this study, we aimed to explore the transcri...
Intestinal permeability and inflammatory features of juvenile age correlate with the eventual systemic autoimmunity in lupus-prone female SWR × NZB F1 (SNF1) mice [0.03%]
肠道通透性和幼年时期的炎症特征与易患红斑狼疮的雌性SWR×NZB F1（SNF1）小鼠终将发生的全身自身免疫相关
Radhika R Gudi,Benjamin M Johnson,Marie-Claude Gaudreau et al.
Radhika R Gudi et al.
The incidence of systemic lupus erythematosus (SLE) is about nine times higher in women than in men, and the underlying mechanisms that contribute to this gender bias are not fully understood. Previously, using lupus-prone (SWR × NZB)F1 (S...
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma [0.03%]
肿瘤浸润细胞上的PD-1表达是复发或难治性弥漫大B细胞淋巴瘤的预后因素
Fumiya Wada,Kimimori Kamijo,Yoshimitsu Shimomura et al.
Fumiya Wada et al.
Background: The tumour microenvironment (TME), which is modulated after immune-chemotherapy, is involved in tumour growth and metastasis. Programmed cell death 1 (PD-1) expressed on tumour-infiltrating non-malignant cells...
Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori [0.03%]
在UreB结构表面嵌合外源性B细胞表位可产生广谱抗幽门螺杆菌抗体反应
Qianyu Ji,Junfei Ma,Shuying Wang et al.
Qianyu Ji et al.
Since Helicobacter pylori (H. pylori) resistance to antibiotic regimens has increased, vaccination is becoming an increasingly important alternative therapy to control H. pylori infection. UreB, FlaA, AlpB, SabA, and HpaA proteins of H. pyl...
Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2 [0.03%]
血红素触发的TLR4信号转导分子机制及血红素结合基序作用的研究
Marie-T Hopp,Janine Holze,Felicitas Lauber et al.
Marie-T Hopp et al.
Haemolytic disorders, such as sickle cell disease, are accompanied by the release of high amounts of labile heme into the intravascular compartment resulting in the induction of proinflammatory and prothrombotic complications in affected pa...
CD8+CD103+PD1+TIM3+ T cells in glioblastoma microenvironment correlate with prognosis [0.03%]
胶质母细胞瘤微环境中CD8+CD103+PD1+TIM3+T淋巴细胞与预后相关性研究
Giulia Romagnoli,Quintino Giorgio D&#x;Alessandris,Imerio Capone et al.
Giulia Romagnoli et al.
Glioblastoma, isocitrate dehydrogenase-wildtype (GB), is the most common and aggressive primary brain malignancy with poor outcome. Immune checkpoint inhibitors (ICIs) have been tested in GB and, despite disappointing results, the identific...
Observational Study
Immunology. 2024 Feb;171(2):198-211. DOI:10.1111/imm.13710 2024