Engineered polyspecific antibodies: A new frontier in the field of immunotherapeutics [0.03%]
工程化多特异性抗体：免疫治疗领域的新前沿
Sandeep,Suraj H Shinde,Sakeel Ahmed et al.
Sandeep et al.
The 21st-century beginning remarked with the huge success of monospecific MAbs, however, in the last couple of years, polyspecific MAbs (PsAbs) have been an interesting topic and show promise of being biobetter than monospecific MAbs. Polys...
Idiotopes of antibodies against HIV-1 CD4-induced epitope shared with those against microorganisms [0.03%]
针对HIV-1诱导的CD4表位与微生物的抗体 idiotopes相似性研究
Shashwata Biswas,Takeo Kuwata,Soichiro Yamauchi et al.
Shashwata Biswas et al.
Induction of antibodies (Abs) against the conformational CD4-induced (CD4i) epitope is frequent in HIV-1 infection. However, the mechanism of development of anti-CD4i Abs is unclear. We used anti-idiotypic (aID) monoclonal Abs (mAbs) of ant...
Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level [0.03%]
针对单个RhD特异性B细胞克隆的IgG-Fc糖基化的评估显示在克隆而非克型水平上的调控
Erik L de Graaf,Mads Delbo Larsen,Nieke van der Bolt et al.
Erik L de Graaf et al.
The type and strength of effector functions mediated by immunoglobulin G (IgG) antibodies rely on the subclass and the composition of the N297 glycan. Glycosylation analysis of both bulk and antigen-specific human IgG has revealed a marked ...
The dual role of regulatory T cells in hepatitis B virus infection and related hepatocellular carcinoma [0.03%]
调节性T细胞在乙肝病毒感染及相关肝癌中的双重作用
Jinan He,Rui Miao,Yao Chen et al.
Jinan He et al.
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths worldwide. Hepatitis B virus (HBV) infection is a major etiologic factor leading to HCC. While there have been significant advancements in controlling HBV replic...
The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function [0.03%]
可溶性IL-2受体α/CD25作为IL-2功能的调节因子
Juliane Lokau,Lynn M Petasch,Christoph Garbers
Juliane Lokau
The pleiotropic cytokine interleukin-2 (IL-2) is an integral regulator of healthy and pathological immune responses, with the most important role in regulating the homeostasis of regulatory T cells. IL-2 signalling involves three distinct r...
Probiotic Bacillus spp. enhance TLR3-mediated TNF signalling in macrophages [0.03%]
芽孢杆菌益生菌增强巨噬细胞中的TLR3介导的TNF信号转导
Katrine Damgaard Winther,Erik Juncker Boll,Dorthe Sandvang et al.
Katrine Damgaard Winther et al.
Probiotics have been reported to have immunomodulatory properties in the context of infectious disease and inflammation, although the underlying mechanisms are not fully understood. Here, we aimed to determine how different probiotic bacter...
Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity [0.03%]
S100A8、S100A9和S100A12在感染、炎症和免疫中的作用
Pengpeng Xia,Xingduo Ji,Li Yan et al.
Pengpeng Xia et al.
S100 proteins are small proteins that are only expressed in vertebrates. They are widely expressed in many different cell types and are involved in the regulation of calcium homeostasis, glucose metabolism, cell proliferation, apoptosis, in...
Applications of single-cell omics for chimeric antigen receptor T cell therapy [0.03%]
单细胞组学在嵌合抗原受体T细胞治疗中的应用
Sasan Ghaffari,Mahshid Saleh,Behnia Akbari et al.
Sasan Ghaffari et al.
Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment modality. The breakthroughs in CAR T cell therapy were, in part, possible with the help of cell analysis methods, such as single-cell analysis. Bulk analyses hav...
Melanoma tumour-derived glycans hijack dendritic cell subsets through C-type lectin receptor binding [0.03%]
黑色素瘤糖类通过C型凝集素受体结合专职性抗原呈递细胞亚群诱导免疫逃逸
Camille Niveau,Eleonora Sosa Cuevas,Benoît Roubinet et al.
Camille Niveau et al.
Dendritic cell (DC) subsets play a crucial role in shaping anti-tumour immunity. Cancer escapes from the control immune system by hijacking DC functions. Yet, bases for such subversion are only partially understood. Tumour cells display abe...
New sights of low dose IL-2: Restoration of immune homeostasis for viral infection [0.03%]
低剂量IL-2的新视野——病毒感染下的免疫稳态重建
Rui Su,Tingting Zhang,Hui Wang et al.
Rui Su et al.
Viral infection poses a significant threat to human health. In addition to the damage caused by viral replication, the immune response it triggers often leads to more serious adverse consequences. After the occurrence of viral infection, in...