Macrophage expressed tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis progression [0.03%]
巨噬细胞表达的抗酒石酸酸性磷酸酶5促进肺纤维化进展
Jesper Bergwik,Ravi Kiran Varma Bhongir,Médea Padra et al.
Jesper Bergwik et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder involving scarring of pulmonary tissue and a subsequent decrease in respiratory capacity, ultimately resulting in death. Tartrate resistant acid phosphatase 5 (ACP5) plays a...
Gut microbiota and intestinal immunity-A crosstalk in irritable bowel syndrome [0.03%]
肠道微生物群和肠道免疫-肠易激综合症的串话
Yuxuan Chen,Shuyan Feng,Ying Li et al.
Yuxuan Chen et al.
Irritable bowel syndrome (IBS), one of the most prevalent functional gastrointestinal disorders, is characterized by recurrent abdominal pain and abnormal defecation habits, resulting in a severe healthcare burden worldwide. The pathophysio...
Jun Ding,Pengyu Chen,Chunjian Qi
Jun Ding
Circadian rhythms are a ubiquitous feature in nearly all living organisms, representing oscillatory patterns with a 24-h cycle that are widespread across various physiological processes. Circadian rhythms regulate a multitude of physiologic...
Adenosine 2A receptor antagonists promote lymphocyte proliferation in sepsis by inhibiting Treg expression of PD-L1 in spleen [0.03%]
腺苷2A受体拮抗剂通过抑制脾脏Treg的PD-L1表达促进脓毒症淋巴细胞增殖
Teng Zhang,Jie Zhao,Ting Zheng et al.
Teng Zhang et al.
The spleen is essential for lymphocyte proliferation, which is associated to sepsis prognosis. Adenosine 2A receptor (A2AR) blocking promotes lymphocyte proliferation in sepsis, however the mechanism is uncertain. Our sepsis cecum ligation ...
Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sjögren's syndrome [0.03%]
性别差异对干燥综合征临床表现、发病机制、治疗和预后影响的研究
Yuhao Xuan,Xiao Zhang,Huaxun Wu
Yuhao Xuan
Sjögren's syndrome is a common chronic autoimmune disease that manifests as dry mouth, dry eyes and systemic complications. There are sex differences in the clinical manifestations between men and women, with the average age of onset being...
Single-cell profiling of bronchoalveolar cells reveals a Th17 signature in neutrophilic severe equine asthma [0.03%]
支气管肺泡细胞的单细胞分析揭示了中重度马哮喘的Th17标记物签名
Sophie E Sage,Tosso Leeb,Vidhya Jagannathan et al.
Sophie E Sage et al.
Severe equine asthma (SEA) is a complex respiratory condition characterized by chronic airway inflammation. It shares many clinical and pathological features with human neutrophilic asthma, making it a valuable model for studying this condi...
TLR7 enhancing follicular helper T (Tfh) cells response in C57BL/6 mice infected with Plasmodium yoelii NSM TLR7 mediated Tfh cells in P. yoelii infected mice [0.03%]
感染了NSM的耶氏疟原虫的小鼠中由TLR7介导的滤泡辅助T细胞反应
Quan Yang,Lu Zhou,Zhengrong Tan et al.
Quan Yang et al.
Toll-like receptors (TLRs) play an important role in inducing innate and acquired immune responses against infection. However, the effect of Toll-like receptor 7 (TLR7) on follicular helper T (Tfh) cells in mice infected with Plasmodium is ...
How to improve translatability and clinical relevance of preclinical studies in rheumatoid arthritis [0.03%]
如何提高风湿性关节炎临床前研究的可转化性和临床相关性
George D Kalliolias,Efthimia K Basdra,Athanasios G Papavassiliou
George D Kalliolias
Comparison of the stability of glycoprotein acetyls and high sensitivity C-reactive protein as markers of chronic inflammation [0.03%]
糖蛋白乙酰化物和高灵敏度C反应蛋白作为慢性炎症标志物的稳定性比较研究
Daisy C P Crick,Golam M Khandaker,Sarah L Halligan et al.
Daisy C P Crick et al.
It has been suggested that glycoprotein acetyls (GlycA) better reflects chronic inflammation than high sensitivity C-reactive protein (hsCRP), but paediatric/life-course data are sparse. Using data from the Avon Longitudinal Study of Parent...
High TSLP responses in the human infant airways are associated with pre-activated airway epithelial IFN antiviral immunity [0.03%]
人类婴儿气道中对TSLP的高反应与气道上皮IFN抗病毒免疫的预活化有关
Allison Welham,Elizabeth Chorvinsky,Surajit Bhattacharya et al.
Allison Welham et al.
Thymic stromal lymphopoietin (TSLP) is a primarily epithelial-derived cytokine that drives type 2 allergic immune responses. Early life viral respiratory infections elicit high TSLP production, which leads to the development of type 2 infla...