Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation [0.03%]
染色质结合型去泛素化酶MYSM1作用于血液生成前体细胞以控制树突状细胞的发展及其对微生物刺激的反应程序
Marwah Mousa,Yue Liang,Lin Tze Tung et al.
Marwah Mousa et al.
Dendritic cells (DCs) are the most significant antigen presenting cells of the immune system, critical for the activation of naïve T cells. The pathways controlling DC development, maturation, and effector function therefore require precis...
Abrogation and homeostatic restoration of IgE responses by a universal IgE allergy CTL vaccine-The three signal self/non-self/self (S/NS/S) theory [0.03%]
通用IgE过敏CTL疫苗通过三信号自我/非自我/自我（S / NS / S）理论废除和恢复IgE反应
Swey-Shen Chen,Hailan Zhang
Swey-Shen Chen
Natural IgE cytotoxic peptides (nECPs), which are derived from the constant domain of the heavy chain of human IgE producing B cells via endoplasmic reticulum (ER) stress, are decorated onto MHC class 1a molecules (MHCIa) as unique biomarke...
The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells [0.03%]
神经滨蛋白样2蛋白（NBEAL2）控制肥大细胞核糖体蛋白RPS6的稳态水平
Philine Wegner,Julia Drube,Lisa Ziegler et al.
Philine Wegner et al.
The Beige and Chediak-Higashi (BEACH) domain-containing, Neurobeachin-like 2 (NBEAL2) protein is a molecule with a molecular weight of 300 kDa. Inactivation of NBEAL2 by loss-of-function mutations in humans as well as deletion of the Nbeal2...
Xuening Liu,Alison Zhao,Su Xiao et al.
Xuening Liu et al.
Immune system imbalances contribute to the pathogenesis of several different diseases, and immunotherapy shows great therapeutic efficacy against tumours and infectious diseases with immune-mediated derivations. In recent years, molecules t...
The correlation between systemic inflammatory markers and efficiency for advanced gastric cancer patients treated with ICIs combined with chemotherapy [0.03%]
系统炎症标志物与接受ICIs联合化疗的晚期胃癌患者疗效的相关性研究
Qiuxia Dong,Fuxing Zhao,Yuying Li et al.
Qiuxia Dong et al.
Currently lacking research to explore the correlation between inflammatory markers and the efficacy of immune checkpoint inhibitors (ICIs) combined with chemotherapy in the treatment of advanced gastric cancer. This study is a retrospective...
Chimerism of avian IgY-scFv and truncated IgG-Fc: A novel strategy in cross-species antibody generation and enhancement [0.03%]
禽IgY-scFv和截短IgG-Fc的嵌合体：交叉物种抗体生成及增强的新策略
Shikun Ge,Alberto Carlos Pires Dias,Xiaoying Zhang
Shikun Ge
Chicken single-chain fragment variable (IgY-scFv) is a functional fragment and an emerging development in genetically engineered antibodies with a wide range of biomedical applications. However, scFvs have considerably shorter serum half-li...
Anti- and pro-inflammatory milieu differentially regulate differentiation and immune functions of oligodendrocyte progenitor cells [0.03%]
抗炎和促炎环境对少突胶质细胞前体细胞的分化及免疫功能有差异性调节作用
Omri Zveik,Ariel Rechtman,Livnat Brill et al.
Omri Zveik et al.
Oligodendrocyte progenitor cells (OPCs) were regarded for years solely for their regenerative role; however, their immune-modulatory roles have gained much attention recently, particularly in the context of multiple sclerosis (MS). Despite ...
Sequential engagement of adhesion molecules and cytokine receptors impacts both piecemeal and anaphylactic degranulation of human basophils [0.03%]
粘附分子和细胞因子受体的顺序结合影响人肥大细胞的片断式与过敏性脱颗粒作用
Ladan Mansouri,Frida Kalm,Sophia Björkander et al.
Ladan Mansouri et al.
Basophils are rare granulocytes in circulation which home to tissues in a process depending on rolling, adhesion and cytokine exposure. However, it is still unclear how these steps affect basophil degranulation. Our aim was to imitate these...
Prognostic biomarkers associated with immune checkpoint inhibitors in hepatocellular carcinoma [0.03%]
与肝细胞癌免疫检查点抑制剂预后相关的生物标志物
Xiu Chen,Liqiu Kou,Xiaolu Xie et al.
Xiu Chen et al.
The treatment of hepatocellular carcinoma (HCC), particularly advanced HCC, has been a serious challenge. Immune checkpoint inhibitors (ICIs) are landmark drugs in the field of cancer therapy in recent years, which have changed the landscap...
Mycobacterium vaccae alleviates allergic airway inflammation and airway hyper-responsiveness in asthmatic mice by altering intestinal microbiota [0.03%]
通过改变肠道微生物,Mycobacterium vaccae缓解了哮喘小鼠的过敏性气道炎症和气道高反应性
Huan Xiao,Li-Ting Fang,An-Zhou Tang et al.
Huan Xiao et al.
Host immunity can influence the composition of the gut microbiota and consequently affect disease progression. Previously, we reported that a Mycobacterium vaccae vaccine could ameliorate allergic inflammation in asthmatic mice by regulatin...