Single-cell RNA sequencing reveals the altered innate immunity in immune checkpoint inhibitor-related myocarditis [0.03%]
单细胞RNA测序揭示了免疫检查点抑制剂相关心肌炎中改变的固有免疫力
Bowen Lou,Manyun Guo,Tao Zheng et al.
Bowen Lou et al.
Myocarditis has emerged as a rare but lethal immune checkpoint inhibitor (ICI)-associated toxicity. However, the exact mechanism and the specific therapeutic targets remain underexplored. In this study, we aim to characterise the transcript...
Early life vaccination reprograms the metabolism and function of myeloid cells in neonates [0.03%]
早年疫苗接种会重新编排新生儿的髓系细胞的代谢和功能
Yingying Chen,Hui Li,Jie Zhou
Yingying Chen
Vaccination after birth provides protection against pathogen infection and immune related disorders in healthy children. The detailed effects of vaccination on neonatal immunity, however, remain largely unknown. Here, we reported that vacci...
NRP1 downregulation correlates with enhanced ILC2 responses during IL-33 challenge [0.03%]
IL-33挑战期间NRP1下调与增强的ILC2反应相关
Ying Wang,Gaoyu Liu,Jianye Wang et al.
Ying Wang et al.
Group 2 innate lymphoid cells (ILC2s) play critical roles in driving the pathogenesis of allergic airway inflammation. The mechanisms underlying the regulation of ILC2s remain to be fully understood. Here, we identified neuropilin-1 (NRP1) ...
Tumour-associated neutrophils: Potential therapeutic targets in pancreatic cancer immunotherapy [0.03%]
肿瘤相关中性粒细胞：胰腺癌免疫治疗中的潜在治疗靶点
Qihang Wu,Han Mao,Zhengting Jiang et al.
Qihang Wu et al.
Pancreatic cancer (PC) is a highly malignant tumour of the digestive system with poor therapeutic response and low survival rates. Immunotherapy has rapidly developed in recent years and has achieved significant outcomes in numerous maligna...
Psychological stress to ovalbumin peptide-specific T-cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell [0.03%]
心理压力通过卵清蛋白肽特异性T细胞受体转基因小鼠影响1型调节性T细胞的抑制能力
Xiaoyu Liu,Xuejie Xu,Yun Liao et al.
Xiaoyu Liu et al.
Numerous diseases of the immune system can be traced back to the malfunctioning of the regulatory T cells. The aetiology is unclear. Psychological stress can cause disruption to the immune regulation. The synergistic effects of psychologica...
NK92 cells and peripheral blood NK cells respond oppositely upon dasatinib treatment [0.03%]
NK92细胞和外周血NK细胞对达沙替尼治疗反应相反
Fengqi Li,Zhongyi Wang,Dongpeng Zheng et al.
Fengqi Li et al.
Natural killer (NK) cell is a valuable tool for immunotherapy in cancer treatment, both the cultured cell line NK92 and primary NK cells are widely studied and used in research and clinical trials. Clinical observations witnessed the improv...
Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment [0.03%]
Pla2g5通过巨噬细胞增殖和LA/Ffar1肺细胞募集促进病毒诱导的肺炎症
Masaya Koganesawa,Daniel F Dwyer,Kinan Alhallak et al.
Masaya Koganesawa et al.
Macrophages expressing group V phospholipase A2 (Pla2g5) release the free fatty acid (FFA) linoleic acid (LA), potentiating lung type 2 inflammation. Although Pla2g5 and LA increase in viral infections, their role remains obscure. We genera...
Role of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them? [0.03%]
气道上皮在病毒性呼吸道感染中的作用：氨溴索能预防或减轻这些疾病吗？
Elisabetta Pace,Serena Di Vincenzo,Maria Ferraro et al.
Elisabetta Pace et al.
Alterations in airway epithelial homeostasis increase viral respiratory infections risk. Viral infections frequently are associated with chronic obstructive pulmonary disease (COPD) exacerbations, events that dramatically promote disease pr...
Myeloid-derived suppressor cells from tumour-bearing mice induce the population expansion of CD19hiFcγRIIbhi regulatory B cells via PD-L1 [0.03%]
携瘤小鼠的髓源抑制性细胞通过PD-L1诱导CD19hiFcγRIIbhi调节性B细胞群体扩增
Wenyan Chen,Xiaomin Ning,Yang Liu et al.
Wenyan Chen et al.
Myeloid-derived suppressor cells (MDSCs) increase in number and gain immunosuppressive functions in tumours and many other pathological conditions. MDSCs are characterized by their strong T-cell immunosuppressive capacity. The effects that ...
Immunopathology in human pulmonary tuberculosis: Inflammatory changes in the plasma milieu and impaired host immune cell functions [0.03%]
人类肺结核的免疫病理变化：血浆环境中的炎症改变和受损的宿主免疫细胞功能
Hubert Senanu Ahor,Monika Vivekanandan,Jean De Dieu Harelimana et al.
Hubert Senanu Ahor et al.
Host immune response is key for protection in tuberculosis, but the causative agent, Mycobacterium (M.) tuberculosis, manages to survive despite immune surveillance. Key mechanisms of immune protection have been identified, but the role of ...