Sialic acid in the regulation of blood cell production, differentiation and turnover [0.03%]
唾液酸在血液细胞生成、分化和更新中的作用
Eric Edward Irons,Sajina Gc,Joseph T Y Lau
Eric Edward Irons
Sialic acid is a unique sugar moiety that resides in the distal and most accessible position of the glycans on mammalian cell surface and extracellular glycoproteins and glycolipids. The potential for sialic acid to obscure underlying struc...
Id1 expression in CD4 T cells promotes differentiation and function of follicular helper T cells and upregulation of related functional molecules [0.03%]
CD4+T细胞中ID1表达促进滤泡辅助性T细胞的分化和功能及其相关效应分子的上调表达
Chen Liu,Xingyue Zeng,Ziqi Xiong et al.
Chen Liu et al.
Although the roles of E proteins and inhibitors of DNA-binding (Id) in T follicular helper (TFH) and T follicular regulatory (TFR) cells have been previously reported, direct models demonstrating the impact of multiple E protein members hav...
Single-cell transcriptomic and T cell antigen receptor analysis of human cytomegalovirus (hCMV)-specific memory T cells reveals effectors and pre-effectors of CD8+- and CD4+-cytotoxic T cells [0.03%]
单细胞转录组和T细胞受体分析揭示人巨细胞病毒特异性记忆T细胞中的效应物和前效应物CD8+和CD4+CTL
Raunak Kar,Somdeb Chattopadhyay,Anjali Sharma et al.
Raunak Kar et al.
Latent human cytomegalovirus (hCMV) infection can pose a serious threat of reactivation and disease occurrence in immune-compromised individuals. Although T cells are at the core of the protective immune response to hCMV infection, a detail...
Prevention and treatment of HPV-related cancer through a mRNA vaccine expressing APC-targeting antigen [0.03%]
通过表达APC靶向抗原的mRNA疫苗预防和治疗HPV相关癌症
Xiaoxuan Li,Huiyan Wang,Wujiang Lai et al.
Xiaoxuan Li et al.
Persistent human papillomavirus (HPV) infection is associated with multiple malignancies. Developing therapeutic vaccines to eliminate HPV-infected and malignant cells holds significant value. In this study, we introduced a lipid nanopartic...
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer [0.03%]
基于TREM1/DAP12的新型多链CAR-T细胞靶向DLL3，对小细胞肺癌有显著抗肿瘤疗效
Fengqi Nie,Yuli Chen,Yanming Hu et al.
Fengqi Nie et al.
Small cell lung cancer (SCLC), recognized as the most aggressive subtype of lung cancer, presents an extremely poor prognosis. Currently, patients with small cell lung cancer face a significant dearth of effective alternative treatment opti...
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids [0.03%]
炎症细胞因子和氧化磷脂对CXCL趋化因子的协同诱导作用
Alma Hodzic,Bernd Gesslbauer,Valery Bochkov et al.
Alma Hodzic et al.
Inflammation is initiated and driven by a mixture of mediators, which modify effects of each other. This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molec...
Omicron breakthrough infections after triple-dose inactivated COVID-19 vaccination: A comprehensive analysis of antibody and T-cell responses [0.03%]
三次接种灭活新冠病毒疫苗后突破性感染Omicron的免疫反应全面分析
Tiandan Xiang,Xufeng Quan,Hang Jia et al.
Tiandan Xiang et al.
This study longitudinally evaluated the immune response in individuals over a year after receiving three doses of an inactivated SARS-CoV-2 vaccine, focusing on reactions to Omicron breakthrough infections. From 63 blood samples of 37 subje...
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome [0.03%]
侧金盏花素通过靶向功能性STING信号体的形成来减轻cGAS-STING介导的疾病
Yan Wang,Guang Xu,Jincai Wen et al.
Yan Wang et al.
Hyperactivation of the cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signalling pathway has been shown to be associated with the development of a variety of inflammatory diseases, and the discovery of an inhibitor of...
Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1 [0.03%]
复制型和非复制型单纯疱疹病毒1的溶瘤活性的比较
Georg Lindner,Annika Walter,Clara L Magnus et al.
Georg Lindner et al.
In 2015, the oncolytic herpes simplex virus 1 (HSV-1) T-VEC (talimogene laherparepvec) was approved for intratumoral injection in non-resectable malignant melanoma. To determine whether viral replication is required for oncolytic activity, ...
Comparative Study
Immunology. 2024 Jun;172(2):279-294. DOI:10.1111/imm.13775 2024
Methyl-supplemented nutrition delays the development of autoimmune disease in pristane-induced murine lupus [0.03%]
甲基补充营养可延迟油佐霉素诱导的小鼠狼疮自身免疫疾病的发展
Silviya Bradyanova,Iliyan Manoylov,Gabriela Boneva et al.
Silviya Bradyanova et al.
The aetiology and progression of systemic lupus erythematosus (SLE) resulted from a complex sequence of events generated both from genetic and epigenetic processes. In the current research, the effect of methyl-supplemented nutrition on the...