Homotherapy for heteropathy: Interleukin-41 and its biological functions [0.03%]
异因同治：白细胞介素-41及其生物学功能
Runfeng Shi,Meixin He,Yongzheng Peng et al.
Runfeng Shi et al.
Interleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. ...
Review
Immunology. 2024 Apr 9. DOI:10.1111/imm.13791 2024
CXCR3+ effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection [0.03%]
效应调节性T细胞与下呼吸道副黏病毒感染期间的疾病耐受相关
Ismail Sebina,Sylvia Ngo,Ridwan B Rashid et al.
Ismail Sebina et al.
Lifestyle factors like poor maternal diet or antibiotic exposure disrupt early life microbiome assembly in infants, increasing the risk of severe lower respiratory infections (sLRI). Our prior studies in mice indicated that a maternal low-f...
A review on comprehending immunotherapeutic approaches inducing ferroptosis: Managing tumour immunity [0.03%]
诱导铁死亡的免疫治疗作用机制及管理肿瘤免疫研究进展综述
Soumyadeep Chattopadhyay,Rudradeep Hazra,Arijit Mallick et al.
Soumyadeep Chattopadhyay et al.
Ferroptosis, a necrotic, iron-dependent controlled cell death mechanism, is distinguished by the development of lipid peroxides to fatal proportions. Malignant tumours, influenced by iron to promote fast development, are vulnerable to ferro...
Radiation-induced fibrosis: Mechanisms and therapeutic strategies from an immune microenvironment perspective [0.03%]
放射诱导的纤维化：从免疫微环境角度解析其机制和治疗策略
Mengting Zheng,Zhonglong Liu,Yue He
Mengting Zheng
Radiation-induced fibrosis (RIF) is a severe chronic complication of radiotherapy (RT) manifested by excessive extracellular matrix (ECM) components deposition within the irradiated area. The lung, heart, skin, jaw, pelvic organs and so on ...
K33 only mutant ubiquitin augments bone marrow-derived dendritic cell-mediated CTL priming via PI3K-Akt pathway [0.03%]
K33-only突变型泛素通过PI3K-Akt途径增强骨髓来源的树突状细胞介导的CTL初始反应
Yi Yun Liang,Xiao Yan Liao,Jun Jun Jia et al.
Yi Yun Liang et al.
To explore the effect of K33 only mutant ubiquitin (K33O) on bone marrow-derived dendritic cells' (BMDCs') maturity, antigen uptake capability, surface molecule expressions and BMDC-mediated CTL priming, and further investigate the role of ...
GLP-1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells [0.03%]
胰高血糖素样肽1受体激动剂通过调节肠道微生物群和第3型固有淋巴样细胞功能来缓解结肠炎
Hanxiao Sun,Jie Shu,Jupei Tang et al.
Hanxiao Sun et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which are drugs used for treating type 2 diabetes, have been reported to exert anti-inflammatory effects on inflammatory bowel disease (IBD), the mechanism of which remains elusive. Here...
The dysfunction of CD8+ T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis [0.03%]
子宫内膜异位病灶成纤维细胞激活的CD8+T细胞功能障碍促进了子宫内膜异位症的免疫逃逸
Zhi-Xiong Huang,Dian-Chao Lin,Hua-Ying Zhang et al.
Zhi-Xiong Huang et al.
Endometriosis is defined as an oestrogen-dependent and inflammatory gynaecological disease of which the pathogenesis remains unclear. This study aimed to investigate the cellular heterogeneity and reveal the effect of CD8+ T cells on the pr...
A new strategy for immunotherapy of microsatellite-stable (MSS)-type advanced colorectal cancer: Multi-pathway combination therapy with PD-1/PD-L1 inhibitors [0.03%]
微卫星稳定型结直肠癌的免疫治疗新策略——PD-1/PD-L1抑制剂多通路联合疗法
Lingli Cai,Anqi Chen,Dong Tang
Lingli Cai
Colorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of morbidity and mortality; 85% of these tumours are proficient mismatch repair (pMMR)-microsatellite instability-low (MSI-L)/microsatellite stable (MSS) CRC ...
Review
Immunology. 2024 Mar 22. DOI:10.1111/imm.13785 2024
The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function [0.03%]
IRF9或STAT2的缺失对人类自然杀伤细胞发育和功能的影响微乎其微
Ane Calvo-Apalategi,Marta López Nevado,Luz Yadira Bravo-Gallego et al.
Ane Calvo-Apalategi et al.
Analysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real-world conditions. Here we have addressed the importance of type I interferon signalling...
Inhibition of leukotriene-B4 signalling-mediated host response to tuberculosis is a potential mode of adjunctive host-directed therapy [0.03%]
白三烯B4信号介导的宿主抗结核免疫反应抑制是潜在的宿主导向治疗作用机制
Ushashi Banerjee,Salik Miskat Borbora,Madhura Guha et al.
Ushashi Banerjee et al.
Treatment of tuberculosis (TB) is faced with several challenges including the long treatment duration, drug toxicity and tissue pathology. Host-directed therapy provides promising avenues to find compounds for adjunctively assisting antimyc...