IL-2 amplifies quantitative TCR signalling inputs to drive Th1 and Th2 differentiation [0.03%]
IL-2通过放大定量的TCR信号输入来驱动Th1和Th2分化
Mohammad Ameen Al-Aghbar,Meritxell Espino Guarch,Nicholas van Panhuys
Mohammad Ameen Al-Aghbar
The activation of CD4+ T-cells in a T cell receptor (TCR)-dependent antigen-specific manner is a central characteristic of the adaptive immune response. In addition to ensuring that CD4+ T-cells recognise their cognate antigen during activa...
Role of novel protein acylation modifications in immunity and its related diseases [0.03%]
新型蛋白脂基化修饰的免疫作用及其相关疾病中的作用机制研究
Xiaoqian Li,Tao Yu,Xiaolu Li et al.
Xiaoqian Li et al.
The cross-regulation of immunity and metabolism is currently a research hotspot in life sciences and immunology. Metabolic immunology plays an important role in cutting-edge fields such as metabolic regulatory mechanisms in immune cell deve...
Review
Immunology. 2024 Jun 12. DOI:10.1111/imm.13822 2024
Regulation of SETD2 maintains immune regulatory function in macrophages to suppress airway allergy [0.03%]
SETD2调节维持巨噬细胞的免疫调控功能以抑制气道过敏反应
Lei Zhang,Junyi Wang,Xiaoyu Liu et al.
Lei Zhang et al.
SET domain-containing 2 (SETD2) is a histone methyltransferase. It regulates the activity of H3K36me3 to enhance gene transcription. Macrophages (Mϕs) are one of the cell types involved in immune response. The purpose of this study is to c...
Expression of GPR56 reflects a hypoactivated state of circulating B cells and is downregulated in B cell subsets in patients with early-stage lung adenocarcinoma [0.03%]
GPR56表达反映了循环B细胞的低活化状态，并在早期肺腺癌患者的B细胞亚群中下调表达
Ayibaota Bahabayi,Zhao Guan,Mohan Zheng et al.
Ayibaota Bahabayi et al.
Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer, and the early detection and diagnosis of this disease are crucial in reducing mortality rates. The timely diagnosis of LUAD is essential for controlling tumour develop...
Impairment of Gal-9 and Tim-3 crosstalk between Tregs and Th17 cells drives tobacco smoke-induced airway inflammation [0.03%]
半乳糖凝集素9和T细胞免疫球蛋白黏蛋白分子3在调节性T细胞和Th17细胞互作中的作用受损驱动烟草烟雾所致气道炎症
Shilin Qiu,Guang Zhou,Junyi Ke et al.
Shilin Qiu et al.
Overexpression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) on T cells has been observed in smokers. However, whether and how galectin-9 (Gal-9)/TIM-3 signal between T-regulatory cells (Tregs) and type 17 helper (Th17) cel...
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2 [0.03%]
淫羊藿黄酮通过作用于小胶质细胞己糖激酶2缓解氧诱导视网膜病变
Xingran Li,Guoqing Wang,Na Li et al.
Xingran Li et al.
Retinopathy of prematurity (ROP) is a retinal disease-causing retinal neovascularization that can lead to blindness. Oxygen-induced retinopathy (OIR) is a widely used ROP animal model. Icariin (ICA) has anti-oxidative and anti-inflammation ...
T cell-intrinsic PKD3 fine-tunes differentiation into CD8+ central memory T cells and CD8 single positive thymocyte development [0.03%]
PKD3通过调节CD8⁺中央记忆T细胞和单阳性胸腺细胞的分化而固有地作用于T细胞中
Jiří Koutník,Sebastian Peer,Dominik Humer et al.
Jiří Koutník et al.
Members of the Protein kinases D (PKD) family are described as regulators of T cell responses. From the two T cell-expressed isoforms PKD2 and PKD3, so far mainly the former was thoroughly investigated and is well understood. Recently, we h...
A unique human cord blood CD8+CD45RA+CD27+CD161+ T-cell subset identified by flow cytometric data analysis using Seurat [0.03%]
一种独特的脐带血CD8+CD45RA+CD27+CD161+T细胞亚群：利用Seurat进行流式数据分析鉴定发现
Julen Gabirel Araneta Reyes,Duan Ni,Brigitte Santner-Nanan et al.
Julen Gabirel Araneta Reyes et al.
Advances in single-cell level analytical techniques, especially cytometric approaches, have led to profound innovation in biomedical research, particularly in the field of clinical immunology. This has resulted in an expansion of high-dimen...
Involvement of Janus kinase-dependent Bcl-xL overexpression in steroid resistance of group 2 innate lymphoid cells in asthma [0.03%]
组2天然淋巴细胞中Bcl-xL的Janus激酶依赖性上调与哮喘糖皮质激素耐药的关系研究
Hayato Shimora,Masaya Matsuda,Yukiko Nakayama et al.
Hayato Shimora et al.
The mechanisms underlying the development of steroid resistance in asthma remain unclear. To establish whether as well as the mechanisms by which the activation of Janus kinases (JAKs) is involved in the development of steroid resistance in...
High common-γ cytokine receptor levels promote expression of Interleukin-2/Interleukin-7 receptor α-chains with implications on T-cell differentiation and function [0.03%]
高水平的共有γ链细胞因子受体促进IL-2/IL-7受体α链表达及其对T细胞分化和功能的影响
Ju-Young Kim,Ertan Mayatepek,Julia Seyfarth et al.
Ju-Young Kim et al.
Cytokines of the common-γ receptor chain (γc) family are crucial for T-cell differentiation and dysregulation of γc cytokine pathways is involved in the pathogenesis of autoimmune diseases. There is increasing evidence that the availabil...