Photodynamic-Immunotherapy Synergy: Decoding the Spatiotemporal Regulation of Tumour Immunogenicity for Enhanced PD-1 Blockade [0.03%]
光动力免疫疗法协同作用：解码肿瘤免疫原性的时空调节以增强PD-1阻断效应
Zhenni ChenLiu,Leihan Wang,Chen Gu et al.
Zhenni ChenLiu et al.
In recent years, breakthrough advancements have been achieved in cancer immunotherapy, particularly through immune checkpoint inhibition targeting the PD-1/PD-L1 pathway. This approach reverses the immunosuppressive effect of tumour cells o...
Review
Immunology. 2025 Oct 8. DOI:10.1111/imm.70049 2025
Characterising the Transcriptomic Response to Interferon and Infection in European Domestic Ferret Respiratory Tissues Using Long-Read RNA Sequencing [0.03%]
采用长读RNA测序技术表征欧洲家Mustela putorius furo呼吸道组织中干扰素和感染的转录组反应
Rubaiyea Farrukee,Jessie J-Y Chang,Jianshu Zhang et al.
Rubaiyea Farrukee et al.
The European domestic ferret (Mustela putorius furo) is considered the gold standard small animal model for studying human and avian influenza virus infections. However, experimental characterisation of the transcriptomic response to interf...
Anastas D Pashov,Jordan D Dimitrov
Anastas D Pashov
Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity. Here, we discuss the diverse molecular mechanisms underlying polyreactivity, including conformational dyna...
Review
Immunology. 2025 Oct 4. DOI:10.1111/imm.70048 2025
Exhaustion-Resistant CD8+ T Cells in Ankylosing Spondylitis: A Proposed Three-Axis Model [0.03%]
强直性脊柱炎中的抗耗竭CD8+t细胞：三轴模型假设
Xuhong Zhang,Lu Jia,Xueni Lin et al.
Xuhong Zhang et al.
Ankylosing spondylitis (AS) is a chronic immune-mediated disease marked by sustained joint inflammation and aberrant bone remodelling. Although chronic antigen exposure usually enforces terminal exhaustion, emerging evidence indicates that ...
Review
Immunology. 2025 Oct 2. DOI:10.1111/imm.70044 2025
Exhaustion-Resistant CD8+ T Cells in Ankylosing Spondylitis: A Proposed Three-Axis Model [0.03%]
强直性脊柱炎中的抗耗竭CD8⁺T细胞：三轴模型假说
Xuhong Zhang,Lu Jia,Xueni Lin et al.
Xuhong Zhang et al.
Ankylosing spondylitis (AS) is a chronic immune-mediated disease marked by sustained joint inflammation and aberrant bone remodelling. Although chronic antigen exposure usually enforces terminal exhaustion, emerging evidence indicates that ...
Review
Immunology. 2025 Oct 2. DOI:10.1111/imm.70044 2025
Mechanism of Tumour-Associated Macrophage-Derived Exosomes in Chemo-Sensitivity of Laryngeal Cancer by Regulating Aerobic Glycolysis via WTAP/GLUT-1 [0.03%]
喉癌肿瘤相关巨噬细胞来源的外泌体通过WTAP/GLUT-1调控细胞糖酵解从而影响化疗敏感性的机制研究
Xingmei Luo,Guodong Li,Yu Chen et al.
Xingmei Luo et al.
Laryngeal cancer (LC) is a condition characterised by cancerous cell development in laryngeal tissues. This article focuses on the mechanism of tumour-associated macrophage-derived exosomes (TAM-Exos) in LC chemosensitivity by mediating Wil...
β-Glucan Protects Against Sepsis-Induced Kupffer Cell Loss by Inhibiting Pyroptosis and Promoting Self-Renewal [0.03%]
β-葡聚糖通过抑制细胞焦亡和促进自我更新抵抗脓毒症诱导的枯氏细胞丢失
Joseph Adams,Tingting Li,Peilin Zhu et al.
Joseph Adams et al.
Sepsis is a life-threatening condition characterised by a dysregulated host response to infection, resulting in systemic inflammation, immune dysfunction, and multi-organ failure. Kupffer cells (KCs), the largest population of tissue-reside...
Challenge Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory [0.03%]
特异性调节佐剂诱导的固有免疫记忆反应的挑战
Samuel T Pasco,Itziar Martín-Ruiz,Sarai Araujo-Aris et al.
Samuel T Pasco et al.
Understanding the innate immune memory induced by adjuvants provides an opportunity to improve vaccine efficacy by inducing nonspecific secondary responses alongside the intended adaptive defence against the target antigen. To understand th...
Isogenic Immune Cells From T-iPSCs for Studying T Cell-Macrophage Interactions [0.03%]
T-iPSC来源的同基因免疫细胞用于研究T细胞-巨噬细胞相互作用
Ludwig Englmeier,Alexandra Lucaciu
Ludwig Englmeier
Huijuan Wan,Bing Liu,Qian Zhang et al.
Huijuan Wan et al.
Lumbar disc herniation (LDH) is a common degenerative spinal disorder traditionally attributed to mechanical compression. However, growing evidence suggests that the immune system plays a crucial role in its pathogenesis. The role of altera...