Dietary human milk oligosaccharides reduce allergic airway inflammation by modulating SCFAs level and ILC2 activity [0.03%]
diets降低过敏性气道炎症通过调节SCFA水平和ILC2活性的作用机制研究
Xu Han,Zhongjie Wang,Hongchuan Cao et al.
Xu Han et al.
Group 2 innate lymphoid cells (ILC2s) play a crucial role in the progression of asthma, yet the regulatory mechanisms modulating ILC2 responses in asthma remain underexplored. Human milk oligosaccharides (HMOs), vital non-nutritive componen...
Plonmarlimab, a novel anti-GM-CSF blocking antibody, ameliorates disease progression in the pre-clinical model of macrophage activation syndrome [0.03%]
一种新型的GM-CSF阻断抗体Plonmarlimab可改善噬血细胞性淋巴组织细胞增多症模型中小鼠的疾病进展
Jian Ding,Ke Xu,Yanling Niu et al.
Jian Ding et al.
Objectives: We aimed to characterize and investigate the safety and efficacy of Plonmarlimab, a novel anti-granulocyte-macrophage colony-stimulating factor (anti-GM-CSF) neutralizing antibody, on the treatment of macropha...
Spatial tertiary lymphoid structures imply response to anti-PD-1 plus anlotinib in advanced non-small cell lung cancer [0.03%]
空间三级淋巴器官结构提示抗PD-1联合安罗替尼治疗晚期非小细胞肺癌的疗效
Jianli Ma,Yuwei Deng,Minghui Zhang et al.
Jianli Ma et al.
Despite breakthroughs of immunotherapy synergistically combined with blockade of vascular endothelial growth factor receptor, several patients with advanced non-small cell lung cancer (NSCLC) experience non-response or followed relapse. Org...
Fibroblast-like synoviocytes preferentially induce terminal differentiation of IgD+ memory B cells instead of naïve B cells [0.03%]
成纤维样滑膜细胞优先诱导IgD+记忆B细胞而非初始B细胞终末分化
Dennis Bleck,Klara Loacker-Schöch,Tim Classen et al.
Dennis Bleck et al.
Rheumatoid arthritis (RA) is a systemic autoimmune disease driven by highly active autoantibody-producing B cells. Activation of B cells is maintained within ectopic germinal centres found in affected joints. Fibroblast-like synoviocytes (F...
Hydroxychloroquine attenuates double-stranded RNA-stimulated hyper-phosphorylation of tristetraprolin/ZFP36 and AU-rich mRNA stabilization [0.03%]
羟氯喹可减轻双链RNA引起的TTP/ZFP36超磷酸化及AU富集mRNA的稳定
Edward G Hitti,Zeyad Muazzen,Walid Moghrabi et al.
Edward G Hitti et al.
The human innate immune system recognizes dsRNA as a pathogen-associated molecular pattern that induces a potent inflammatory response. The primary source of pathogenic dsRNA is cells infected with replicating viruses, but can also be relea...
SOX17 orchestrates immune evasion in early colorectal adenomas and cancers [0.03%]
SOX17在早期结肠腺瘤和癌症中的免疫逃逸作用
Bo Pei,Huiye Yang,Fuxiang Zhou
Bo Pei
Yuri Chaves Martins,Pamela Rosa-Gonçalves,Cláudio Tadeu Daniel-Ribeiro
Yuri Chaves Martins
The clonal selection theory (CST) is the centrepiece of the current paradigm used to explain immune recognition and memory. Throughout the past decades, the original CST had been expanded and modified to explain new experimental evidences s...
Peripheral blood MR1 tetramer-positive mucosal-associated invariant T-cell function is modulated by mammalian target of rapamycin complex 1 in patients with active tuberculosis [0.03%]
活动性肺结核患者外周血MR1单体阳性黏膜相关不变T细胞功能受哺乳动物雷帕霉素靶点复合物1调节
Chao-Ying Zhou,Ya-Long Yang,Zhen-Yu Han et al.
Chao-Ying Zhou et al.
Tuberculosis (TB) is still an urgent global public health problem. Notably, mucosal-associated invariant T (MAIT) cells play an important role in early anti-TB immune response. Targeted control of them may be an effective method to improve ...
NME4 suppresses NFκB2-CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma [0.03%]
NME4通过抑制NFκB2-CCL5轴限制食管鳞癌中CD8+T细胞浸润
Shutao Zheng,Shuo He,Yan Liang et al.
Shutao Zheng et al.
Thought of as a metastasis-associated gene, however, NME/NM23 nucleoside diphosphate kinase 4 (NME4) has rarely been described in the context of the tumour microenvironment. To understand the immunological implications of NME4 in oesophagea...
Roles of Menin in T cell differentiation and function: Current knowledge and perspectives [0.03%]
Menin在T细胞分化和功能中的作用：现有知识与展望
Pingping Zhou,Weiru Liu,Jian Ma
Pingping Zhou
The commitment to specific T lymphocytes (T cell) lineages is governed by distinct transcription factors, whose expression is modulated through epigenetic mechanisms. Unravelling these epigenetic mechanisms that regulate T cell differentiat...