Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis [0.03%]
纳米医学在靶向类风湿关节炎TNFR2中的作用机制的研究进展
Fatmawati Lambuk,Nor Asyikin Nordin,Ali Mussa et al.
Fatmawati Lambuk et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovium and progressive joint destruction which significantly affects both quality of life and socioeconomic status. Admittedly, various treatme...
Microscopic marvels: Decoding the role of micropeptides in innate immunity [0.03%]
微观奇迹：揭秘微肽在先天免疫中的作用
Praveena Naidu,Mandë Holford
Praveena Naidu
The innate immune response is under selection pressures from changing environments and pathogens. While sequence evolution can be studied by comparing rates of amino acid mutations within and between species, how a gene's birth and death co...
Hypoxic tumour-derived exosomal miR-1290 exacerbates the suppression of CD8+ T cells by promoting M2 macrophage polarization [0.03%]
缺氧肿瘤衍生的外泌体miR-1290通过促进M2型巨噬细胞极化来加重对CD8⁺T淋巴细胞的抑制作用
Yeni Yang,Tiansong Wu,Youpeng Wang et al.
Yeni Yang et al.
Hypoxia plays an important role in the metastasis of hepatocellular carcinoma (HCC). Exosomes have been widely studied as mediators of communication between tumours and immune cells. However, the specific mechanism by which hypoxic HCC cell...
Altered epitopes enhance macrophage-mediated anti-tumour immunity to low-immunogenic tumour mutations [0.03%]
修饰的表位可增强巨噬细胞介导的低免疫原性肿瘤突变的抗肿瘤免疫反应
Qiumin Yu,Tingran Zhang,Tiandi He et al.
Qiumin Yu et al.
Personalized neoantigen therapy has shown long-term and stable efficacy in specific patient populations. However, not all patients have sufficient levels of neoantigens for treatment. Although somatic mutations are commonly found in tumours...
Advancement in the development of mRNA-based vaccines for respiratory viruses [0.03%]
基于mRNA的呼吸道病毒疫苗开发进展
Tays Troncoso-Bravo,Mario A Ramírez,Ricardo A Loaiza et al.
Tays Troncoso-Bravo et al.
Acute respiratory infections are the leading cause of death and illness in children under 5 years old and represent a significant burden in older adults. Primarily caused by viruses infecting the lower respiratory tract, symptoms include co...
The role and therapeutic strategies for tissue-resident memory T cells, central memory T cells, and effector memory T cells in psoriasis [0.03%]
组织定位记忆T细胞、中央记忆T细胞和效应记忆T细胞在银屑病中的作用及治疗策略
Guoshu Deng,Yulin Zhang,Jiankun Song et al.
Guoshu Deng et al.
Psoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of...
Mast cells contribute to T-cell accumulation in the bronchoalveolar space in mice with IL-33-induced airway inflammation [0.03%]
髓细胞学稳定细胞有助于T细胞积累在小鼠支气管肺泡空间中由IL-33诱导的呼吸道炎症
P Abigail Alvarado-Vazquez,Erika Mendez-Enriquez,Lisa Pähn et al.
P Abigail Alvarado-Vazquez et al.
Interleukin (IL)-33 released from airway epithelial cells plays a vital role in shaping type 2 immune responses by binding to the ST2 receptor present in many immune cells, including mast cells (MCs). Intranasal administration of IL-33 in m...
Unravelling CD24-Siglec-10 pathway: Cancer immunotherapy from basic science to clinical studies [0.03%]
解密CD24-Siglec-10通路：从基础研究到临床试验的癌症免疫治疗
Rudradeep Hazra,Soumyadeep Chattopadhyay,Arijit Mallick et al.
Rudradeep Hazra et al.
Cancer immunotherapy has revolutionized the treatment landscape by harnessing the power of the immune system to combat malignancies. Two of the most promising players in this field are cluster of differentiation 24 (CD24) and sialic acid-bi...
Edwardsiella tarda induces airways inflammation and production of autoantibodies against lung tissues through regulation of the IL-33-ST2 axis [0.03%]
爱德华氏菌感染通过调节IL-33-ST2轴诱导气道炎症和肺组织自身抗体产生
Yue Hu,Zhihong Feng,Gao An et al.
Yue Hu et al.
Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic respiratory disease characterised by irreversible airways obstruction associated with chronic airways inflammation and remodelling, while the pathogenesis and the me...
Sofia Maceratessi,Natalia G Sampaio
Sofia Maceratessi
During virus infection, many host proteins are redirected from their normal cellular roles to restrict and terminate infection. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are cellular RNA-binding proteins critical to host nucleic aci...