Iivo Hetemäki,T Petteri Arstila,Eliisa Kekäläinen
Iivo Hetemäki
Transcription factor Helios, encoded by the IKZF2 gene, has an important role in regulatory T cells by stabilizing their suppressive phenotype. While Helios is prominently expressed in regulatory T cells, its expression extends beyond to in...
How maternal factors shape the immune system of breastfed infants to alleviate food allergy: A systematic and updated review [0.03%]
母体因素通过影响母乳喂养婴儿的免疫系统来缓解食物过敏：系统性和更新后的回顾性研究
Yuhong Wu,Bihua Chen,Huan Wu et al.
Yuhong Wu et al.
What infants eat early in life may shape the immune system and have long-standing consequences on the health of the host during later life. In the early months post-birth, breast milk serves as the exclusive and optimal nourishment for infa...
RNA technology and nanocarriers empowering in vivo chimeric antigen receptor therapy [0.03%]
RNA技术与纳米载体赋能体内嵌合抗原受体治疗
Jingsheng Cai,Shaoyi Chen,Zheng Liu et al.
Jingsheng Cai et al.
The remarkable success of mRNA-based coronavirus 2019 (COVID-19) vaccines has propelled the advancement of nanomedicine, specifically in the realm of RNA technology and nanomaterial delivery systems. Notably, significant strides have been m...
Expression of RAG and secondary gene rearrangement of BCR in mature peripheral B lymphocytes in Takayasu arteritis [0.03%]
Takayasu动脉炎外周成熟B淋巴细胞RAG表达及BCR二次重排现象研究
Zhenni Wang,Zongxu Jing,Xiaoyun Luo
Zhenni Wang
To evaluate the expression of recombinant activating gene (RAG) and B cell receptor (BCR) gene rearrangements in mature peripheral B lymphocytes in Takayasu arteritis (TA) to explore the possible mechanism of humoral immune response in TA. ...
Multiomic-based immune response profiling in migraine, vestibular migraine and Meniere's disease [0.03%]
基于多组学的免疫反应在偏头痛、前庭性偏头痛和梅尼埃病中的特征分析
Pablo Cruz-Granados,Lidia Frejo,Patricia Perez-Carpena et al.
Pablo Cruz-Granados et al.
Migraine (MI) is the most common neurological disease, affecting with 20% of the world population. A subset of 25% of MI patients showcase concurrent vestibular symptoms, which may classify as vestibular migraine (VM). Meniere's disease (MD...
Aspergillus fumigatus-derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production in macrophages [0.03%]
烟曲霉衍生的gliotoxin通过调节巨噬细胞脂质介质生成从而影响先天免疫细胞活化
Kerstin Günther,Vivien Nischang,Zoltan Cseresnyés et al.
Kerstin Günther et al.
Gliotoxin (GT), a secondary metabolite and virulence factor of the fungal pathogen Aspergillus fumigatus, suppresses innate immunity and supports the suppression of host immune responses. Recently, we revealed that GT blocks the formation o...
Identification of psoriasis-associated immune marker G3BP2 through single-cell RNA sequencing and meta analysis [0.03%]
通过单细胞RNA测序和元分析鉴定银屑病相关免疫标记G3BP2
Shuangshuang Gao,Huayu Fan,Ting Wang et al.
Shuangshuang Gao et al.
Psoriasis is a chronic skin disease with an increasing prevalence each year. However, the mechanisms underlying its onset and progression remain unclear, and effective therapeutic targets are lacking. Therefore, we employs an innovative app...
Meta-Analysis
Immunology. 2024 Dec;173(4):730-747. DOI:10.1111/imm.13851 2024
Inherent metabolic preferences differentially regulate the sensitivity of Th1 and Th2 cells to ribosome-inhibiting antibiotics [0.03%]
固有的代谢偏好不同地调节Th1和Th2细胞对核糖体抑制抗生素的敏感性
Neha Jawla,Raunak Kar,Veena S Patil et al.
Neha Jawla et al.
Mitochondrial translation is essential to maintain mitochondrial function and energy production. Mutations in genes associated with mitochondrial translation cause several developmental disorders, and immune dysfunction is observed in many ...
CCR5-mediated homing of regulatory T cells and monocytic-myeloid derived suppressor cells to dysfunctional endothelium contributes to early atherosclerosis [0.03%]
CCR5介导的调节性T细胞和单核-髓源性抑制细胞向功能障碍内皮细胞归巢参与早期动脉粥样硬化病变形成
Shamima Akhtar,Komal Sagar,Ambuj Roy et al.
Shamima Akhtar et al.
A disbalance between immune regulatory cells and inflammatory cells is known to drive atherosclerosis. However, the exact mechanism is not clear. Here, we investigated the homing of immune regulatory cells, mainly, regulatory T cells (Tregs...
Contributions of each of the BAFF receptors to the lymphocyte profiles in C57BL/6 mice [0.03%]
BAFF受体分别对C57BL/6小鼠淋巴细胞谱型的贡献率
William Stohl,Ying Wu,Malka Stohl
William Stohl
BAFF, a vital B cell survival and differentiation factor, has three receptors: B-cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI) and BR3. Although B cells are greatly reduced in B6.Baff-/- (which harbour n...