LGR4 Deficiency Aggravates Skin Inflammation and Epidermal Hyperplasia in Imiquimod-Induced Psoriasis [0.03%]
LGR4缺陷通过加重咪喹莫德诱导的银屑病小鼠模型中的皮肤炎症和表皮增生促进银屑病进展
Mengfei Xue,Ruijie Yang,Guihong Li et al.
Mengfei Xue et al.
Psoriasis is a chronic inflammatory skin disease characterised by inflammatory cell infiltration, keratinocyte hyperproliferation and increased neovascularization. Despite extensive research, the precise mechanisms underlying psoriasis path...
SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells [0.03%]
SNX17通过树突细胞调节抗原内吞和吞噬体成熟
Sofía Dinamarca,Cristina Croce,Anna Salvioni et al.
Sofía Dinamarca et al.
Antigen cross-presentation is the process whereby small peptides derived from exogenous antigens are attached to MHC-I molecules triggering CD8+ T lymphocyte activation. The endocytic route of dendritic cells (DCs) is highly specialised for...
Metabolic Regulation of Inflammation: Exploring the Potential Benefits of Itaconate in Autoimmune Disorders [0.03%]
代谢调控炎症：探究衣康酸在自身免疫性疾病中的潜在益处
Yin Luo,Li-Yan Jiang,Zhe-Zhen Liao et al.
Yin Luo et al.
Itaconic acid and its metabolites have demonstrated significant therapeutic potential in various immune diseases. Originating from the tricarboxylic acid cycle in immune cells, itaconic acid can modulate immune responses, diminish inflammat...
Review
Immunology. 2024 Nov 14. DOI:10.1111/imm.13875 2024
Hulya Kose,Orhan Gorukmez,Sara Sebnem Kilic
Hulya Kose
Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment [0.03%]
癌症代谢重塑与免疫抑制微环境
Durre Aden,Niti Sureka,Samreen Zaheer et al.
Durre Aden et al.
Cancer is a complex and heterogeneous disease characterised by uncontrolled cell growth and proliferation. One hallmark of cancer cells is their ability to undergo metabolic reprogramming, which allows them to sustain their rapid growth and...
Sphingosine-1-Phosphate Signalling Inhibition Suppresses Th1-Like Treg Generation by Reversing Mitochondrial Uncoupling [0.03%]
鞘氨醇-1-磷酸信号通路抑制通过逆转线粒体解偶联抑制Th1样Treg的生成
Rachel Coulombeau,Claudia Selck,Nicolas Giang et al.
Rachel Coulombeau et al.
Inflammatory environments induce the generation of dysfunctional IFNγ+T-bet+FOXP3+ Th1-like Tregs, which show defective function and are found in autoimmune conditions including multiple sclerosis (MS). The pathways that control the genera...
RGS10 Deficiency Alleviated Intestinal Mucosal Inflammation Through Suppression of Th1/Th17 Cell Immune Responses in Ulcerative Colitis [0.03%]
RGS10缺乏通过抑制溃疡性结肠炎的Th1/Th17细胞免疫反应缓解肠道黏膜炎症
Yonghong Yang,Yiming Shao,Xizhuang Gao et al.
Yonghong Yang et al.
Regulator of G-protein signalling (RGS) 10 plays critical roles in several immune related diseases. However, whether RGS10 is involved in colonic inflammation of ulcerative colitis (UC) is still obscure. This study aimed to investigate the ...
The Immune Regulatory Functions in B Cells Are Restored by CpG to Reduce Experimental Food Allergy [0.03%]
CpG恢复B细胞的免疫调节功能以减轻实验性食物过敏
Qiao Liu,Dong-Hua Bin,Zhuo-Ya Wang et al.
Qiao Liu et al.
Dysfunctional immune regulation contributes to the pathogenesis of food allergy (FA). The mechanism behind regulatory B-cell dysfunction is unclear. CpG has immune regulatory functions. The purpose of this study is to use CpG to recover the...
Downregulation of type I interferon signalling pathway by urate in primary human PBMCs [0.03%]
尿酸通过下调初始人外周血单个核细胞中I型干扰素信号途径发挥免疫抑制作用
Medeea Badii,Valentin Nica,Ancuța R Straton et al.
Medeea Badii et al.
Type I interferons (IFN1s) mediate innate responses to microbial stimuli and regulate interleukin (IL)-1 and IL-1 receptor antagonist (Ra) production in human cells. This study explores interferon-stimulated gene (ISG) alterations in the tr...
New Engineered-Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E [0.03%]
一种新型的肉毒杆菌素嵌合体神经毒素突变体可有效同时预防A型和E型肉毒杆菌素中毒
Jingrong Wang,Jiansheng Lu,Bolin Li et al.
Jingrong Wang et al.
Botulinum neurotoxins (BoNTs), including serotypes A and E, are potent biotoxins known to cause human poisoning. In addition to the critical protective antigen found in the full BoNT molecule, the receptor binding domain (Hc domain), BoNTs ...