Icariin Induces Chondrocyte Degeneration via Activation of the NF-κB Signalling Pathway and Reduces the Inflammation Factor Expression Induced by Lipopolysaccharide [0.03%]
淫羊藿苷通过激活NF-κB信号通路诱导软骨细胞退化并降低脂多糖诱导的炎症因子表达
Tianjun Zhai,Jie Wang,Yeping Chen et al.
Tianjun Zhai et al.
To investigate the effect of icariin on chondrocytes by activating the nuclear factor kappa-B (NF-κB) signalling pathway and the mechanism of icariin in inducing chondrocytes degeneration. Chondrocytes were cultured in vitro and treated wi...
Maternal Carriage of Prevotella copri Is Associated With Increased Thymus Derived Naïve Regulatory T Cells in Cord Blood [0.03%]
母体携带普雷沃氏菌与脐带血中来源于胸腺的初始调节T细胞增加有关
Yuan Gao,Martin O&#x;Hely,Fiona Collier et al.
Yuan Gao et al.
Impact of Pre-Infection COVID-19 Vaccination on the Incidence and Severity of Long COVID: A Retrospective Case-Control Study [0.03%]
新冠感染前接种疫苗对长新冠的发生和严重程度的影响：病例对照回顾性研究
Elena Barado,Silvia Carlos,Laura Moreno-Galarraga et al.
Elena Barado et al.
Long COVID is an emerging condition with an important impact on the quality of life of affected individuals. This study aims to analyse the association between complete vaccination prior to SARS-CoV-2 infection and the subsequent developmen...
X-Ray Crystallography Based Epitope Mapping of Glycoproteins and RNA in Chandipura Vesiculovirus for Vaccine Design [0.03%]
基于X射线晶体学的加尼亚-vesiculo病毒糖蛋白和RNA表位图谱绘制与疫苗设计
Aron Rodrick Lakra
Aron Rodrick Lakra
This study investigates potential epitopes in the glycoprotein and RNA of Chandipura vesiculovirus (CHPV) using MHC Class I (HLA-A0201) and MHC Class II (DRB1_0101) molecules with 3D structures derived from x-ray crystallography. Computatio...
Epstein-Barr Virus-Induced 3 Attributes to TLR7-Mediated Splenomegaly [0.03%]
EB病毒通过诱导EBI3促进TLR7介导的脾大反应
Masanori Iseki,Yuma Sakamoto,Daiki Takezaki et al.
Masanori Iseki et al.
Epstein-Barr virus-induced 3 (EBI3) functions as a component of the heterodimer cytokine IL-27, which regulates innate and acquired immune responses. The expression of EBI3 gene is induced by Toll-like receptors (TLRs). Repeated treatment w...
Renal and Peripheral Blood Transcriptome Signatures That Predict Treatment Response in Proliferative Lupus Nephritis-A Prospective Study [0.03%]
预测增生性狼疮肾炎治疗反应的肾脏和外周血转录组标志物-一项前瞻性研究
Sree Nethra Bulusu,Anitha Nagaraj Bavikatte,Sanket Shah et al.
Sree Nethra Bulusu et al.
Mechanisms contributing to non-response to treatment in lupus nephritis (LN) are unclear. We characterised the transcriptome of paired peripheral blood mononuclear cells (PBMCs) and renal tissues in LN before and after cyclophosphamide (CYC...
A Novel Polymersome Nanocarrier Promotes Anti-Tumour Immunity by Improved Priming of CD8+ T Cells [0.03%]
一种新型聚合物纳米载体通过有效启动CD8⁺T细胞促进抗肿瘤免疫响应
Regine J Dress,William W Ho,Victor Ho et al.
Regine J Dress et al.
Cancer is one of the leading causes of death worldwide. In recent years, immune checkpoint inhibitor therapies, in addition to standard immuno- or chemotherapy and surgical approaches, have massively improved the outcome for cancer patients...
The Role of Innate Immunity in Healthy Aging Through Antimicrobial Peptides [0.03%]
抗菌肽在健康老龄化过程中固有免疫的作用
Yejin Cho,Jeong-Hoon Hahm
Yejin Cho
In a super-aging society, the increase in the elderly population is closely tied to a rise in infectious diseases due to factors such as weakened immune systems and decreased vaccine efficacy in older adults. Various opportunistic pathogens...
Review
Immunology. 2025 Jan 21. DOI:10.1111/imm.13899 2025
TYK2:p.Pro1104Ala Variant Protects Against Autoimmunity by Modulating Immune Cell Levels [0.03%]
TYK2:p.Pro1104Ala变异通过调节免疫细胞水平对抗自身免疫反应
Maristella Steri,Valeria Orrù,Carlo Sidore et al.
Maristella Steri et al.
The TYK2:p.Pro1104Ala (rs34536443) hypomorph variant has been associated with protection against numerous autoimmune disorders. Thus, its mechanism of action becomes of great interest. Here, consistent with the participation of activated im...
IL-6 Signalling to Responding T Cells Is Key to Calcitonin Gene-Related Peptide-Exposed Endothelial Cell Enhancement of Th17 Immunity During Langerhans Cell Antigen Presentation [0.03%]
朗格汉斯细胞抗原呈递过程中，补体因子C5a诱导的内皮细胞促进Th17免疫的关键机制研究
Wanhong Ding,Cameron Moattari,Lori L Stohl et al.
Wanhong Ding et al.
Calcitonin gene-related peptide (CGRP) biases Langerhans cell (LC) Ag presentation to CD4+ T cells towards Th17-type immunity through actions on endothelial cells (ECs). We now report further evidence that IL-6 signalling at responding T ce...