Rachael J M Bashford-Rogers,Kenneth G C Smith,David C Thomas
Rachael J M Bashford-Rogers
High-throughput sequencing of the DNA/RNA encoding antibody heavy- and light-chains is rapidly transforming the field of adaptive immunity. It can address key questions, including: (i) how the B-cell repertoire differs in health and disease...
Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice [0.03%]
鼠II型鸟苷酸酶表达缺乏而不改变I型鸟苷酸酶的表达能缓解实验性自身免疫性脑脊髓炎
Mariam Choudry,Xiaolei Tang,Tiffany Santorian et al.
Mariam Choudry et al.
In the past there have been a multitude of studies that ardently support the role of arginase II (Arg II) in vascular and endothelial disorders; however, the regulation and function of Arg II in autoimmune diseases has thus far remained unc...
Anuja Mathew
Anuja Mathew
In recent years, our understanding of the complex number of signals that need to be integrated between a diverse number of receptors present on natural killer (NK) cells and ligands present on target cells has improved. Here, we review the ...
The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination [0.03%]
感染或接种后resident、中央和效应记忆CD4+t细胞在保护性免疫中的作用
Joshua I Gray,Lotus M Westerhof,Megan K L MacLeod
Joshua I Gray
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T-cells play a central role in all adaptive immune responses. Vaccines must, therefore, activate CD4 T-cells if they ar...
Antigen-specific airway IL-33 production depends on FcγR-mediated incorporation of the antigen by alveolar macrophages in sensitized mice [0.03%]
抗原特异性气道IL-33的产生依赖于FcγR介导的肺泡巨噬细胞在致敏小鼠中对靶标的摄取
Takeshi Nabe,Masaya Matsuda,Tomoki Ishida et al.
Takeshi Nabe et al.
Although interleukin (IL)-33 is a candidate for the aggravation of asthma, the mechanisms underlying antigen-specific IL-33 production in the lung are unclear. Therefore, we analysed the mechanisms in mice. Intra-tracheal administration of ...
Chang H Kim
Chang H Kim
Commensal microbes and the host immune system have been co-evolved for mutual regulation. Microbes regulate the host immune system, in part, by producing metabolites. A mounting body of evidence indicates that diverse microbial metabolites ...
Innate-like CD8+ T-cells and NK cells: converging functions and phenotypes [0.03%]
具天然杀伤细胞功能和表型的CD8⁺T细胞
Ayako Kurioka,Paul Klenerman,Christian B Willberg
Ayako Kurioka
New data in the worlds of both innate-like CD8+ T-cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely se...
Murine neutrophils treated with alphaB-crystallin reduce IL-12p40 production by dendritic cells [0.03%]
αB-晶体蛋白处理的小鼠中性粒细胞可减少树突状细胞产生的IL-12p40
Trisha M Finlay,Alexandra L Palmer,Shalina S Ousman
Trisha M Finlay
Neutrophils are essential in the fight against invading pathogens. They utilize antimicrobial effector mechanisms, such as phagocytosis, release of proteases and other antimicrobial products, robust oxidative bursts and neutrophil extracell...
Jodie Stephenson,Erik Nutma,Paul van der Valk et al.
Jodie Stephenson et al.
Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining increased attention as they impose a considerable socioeconomic impact, due in part to the ageing community. Neuronal damage is a pathological hallmark o...
Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T-cell-associated autoimmunity [0.03%]
盐暴露增加影响淋巴细胞和髓系效应功能，影响先天相关疾病但不影响T细胞自身免疫反应
Daniëlle Vaartjes,Kutty-Selva Nandakumar,Rikard Holmdahl et al.
Daniëlle Vaartjes et al.
High salt consumption has since long been associated with elevated blood pressure and cardiovascular disease. Recently, mouse studies suggested that a high dietary salt intake exacerbates the clinical manifestations of autoimmunity. Using n...