The Contribution of Complement System in Multiple Sclerosis: Mechanisms and Therapeutic Potentials [0.03%]
补体系统在多发性硬化症中的作用：机制和治疗潜力
Runjing Cao,Li-Wen Zhu,Bo Chen et al.
Runjing Cao et al.
The complement system has been described as playing key roles in both innate and adaptive immune responses. Multiple sclerosis (MS) is an autoimmune disease characterised by the destruction of myelinated axons in the central nervous system ...
Review
Immunology. 2025 Apr 16. DOI:10.1111/imm.13929 2025
Alonso D Cruz-Cruz,Jocelyn C Pérez-Lara,Diana Z Velázquez et al.
Alonso D Cruz-Cruz et al.
Salmonella enterica serovar Typhimurium (S. Tm) can colonise different intracellular niches, either actively dividing or remaining dormant to persist. Bacterial persisters are phenotypic variants that temporarily enter a nonreplicative stat...
SAA1 as a Potential Early Diagnostic Biomarker for Sepsis Through Integrated Proteomics and Metabolomics [0.03%]
整合蛋白质组学和代谢组学发现SAA1可作为潜在的早期诊断脓毒症生物标志物
Mengyao Yuan,Pengfei Huang,Yuhan Liu et al.
Mengyao Yuan et al.
Sepsis is characterised by fatal organ dysfunction resulting from a dysfunctional host response to infection, imposing a substantial economic burden on families and society. Therefore, identifying biomarkers for early sepsis diagnosis and i...
Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS) [0.03%]
结核分枝杆菌麦氏亚种副结核分支菌与意大利炎症性肠病及肠易激综合征患者内源性逆转录病毒的关系研究
Stefano Ruberto,Alfredo Santovito,Gian P Caviglia et al.
Stefano Ruberto et al.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD) and irritable bowel syndrome (IBS) are distinct gastrointestinal disorders. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in...
Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell-Dendritic Cell Interaction [0.03%]
固有免疫激活是CCL22的强烈抑制因子，并阻碍调节T细胞-树突细胞相互作用
Ignazio Piseddu,Jan Gärtig,Stephan Eiber et al.
Ignazio Piseddu et al.
The chemokine CCL22 is constitutively expressed at high levels in lymphoid organs, where it controls immunity by promoting contacts between dendritic cells (DC) and regulatory T cells (Treg). However, its regulation and impact in the contex...
Targeting Immune Cell Metabolism: A Promising Therapeutic Approach for Cardiovascular Disease [0.03%]
靶向免疫细胞代谢：心血管疾病治疗的新希望
Dexiang Xia,Qinwen Zheng,Yue Liu et al.
Dexiang Xia et al.
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally. Recent groundbreaking preclinical and clinical research underscores the pivotal role of metabolite remodelling in the pathology of CVD. This metabolic tran...
Review
Immunology. 2025 Mar 24. DOI:10.1111/imm.13913 2025
Upregulated TCF1+ Treg Cells With Stronger Function in Systemic Lupus Erythematosus Through Activation of the Wnt-β-Catenin [0.03%]
系统性红斑狼疮中通过Wnt-β-catenin激活具有更强功能的TCF1+Treg细胞的上调
Xingyue Zeng,Yiming Gao,Ayibaota Bahabayi et al.
Xingyue Zeng et al.
The role of T-cell factor 1 (TCF1) in human regulatory T cells (Treg) and its clinical significance in systemic lupus erythematosus (SLE) remain unclear. Through bioinformatics analysis and flow cytometry, the Tcf7 gene and TCF1 protein wer...
Optimization of Immunotherapy Strategies Based on Spatiotemporal Heterogeneity of Tumour-Associated Tissue-Resident Memory T Cells [0.03%]
基于肿瘤相关组织驻留记忆T细胞的时空异质性的免疫疗法策略优化
Yile Shang,Yinjun He,Xiang Zhang et al.
Yile Shang et al.
Tissue-resident memory T cells (TRMs) reside in peripheral tissues and provide rapid immune defence against local infection and tumours. Tumour-associated TRMs share common tissue-resident features and formation mechanisms, representing som...
Review
Immunology. 2025 Mar 20. DOI:10.1111/imm.13924 2025
Reversing Microglial Polarisation by High Intensity Interval Training: A Novel Approach to Mitigate Inflammatory Responses in Osteoarthritis via Jak2/Stat3 Pathway [0.03%]
高强度间歇训练逆转小胶质细胞极化：通过Jak2/Stat3通路减轻骨关节炎炎症反应的新方法
Xinwei Wang,Mingxia Gao,Peng Xia et al.
Xinwei Wang et al.
Osteoarthritis (OA) is associated with inflammatory responses linked to microglial polarisation within the central nervous system. However, exploring therapeutic approaches and their underlying mechanisms remains a direction for future rese...
Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS-CoV-2-Induced Immune Responses [0.03%]
通过蛋白质组学分析破译SARS-CoV-2诱导免疫反应中潜在靶点的IgG独特型网络
Nicolle Rakanidis Machado,Beatriz Oliveira Fagundes,Lais Alves do Nascimento et al.
Nicolle Rakanidis Machado et al.
The association between COVID-19 and autoimmune diseases has gained increasing recognition, yet the specific targets of SARS-CoV-2-induced IgG are currently in focus for several studies. This study aims to explore the proteomic targets of t...