A morphomolecular study of 175 'USP6-associated neoplasms': The USP6 fusion partner strongly depends on morphology and location [0.03%]
175例XPO018/USP6肿瘤的形态分子学研究：USP6融合伴侣强烈依赖于肿瘤的形态和发生部位
Fleur Cordier,Jo Van Dorpe,Raf Sciot et al.
Fleur Cordier et al.
Context: Nodular fasciitis (NF), myositis ossificans/fibro-osseous pseudotumor of the digits (MO/FP) and aneurysmal bone cyst (ABC) are grouped under the category of 'USP6-associated neoplasms' (UANs) due to their shared ...
Transcription factor-based subtype assignment in pulmonary large cell neuroendocrine carcinoma [0.03%]
基于转录因子的肺大细胞神经内分泌癌亚型分配
Yin P Hung,Komson Wannasai,Catherine B Meador et al.
Yin P Hung et al.
Aims: Pulmonary large cell neuroendocrine carcinoma (LCNEC) can be difficult to diagnose due to histological overlap with small cell lung carcinoma (SCLC). SCLC comprises multiple transcription factor-based subtypes. We a...
Adult granulosa cell tumours of the testis analogous to ovarian counterparts are exceptionally rare: analysis of a multicentric series and review of the literature [0.03%]
睾丸颗粒细胞瘤类似于卵巢同名肿瘤，极为罕见：多中心系列研究及文献综述
Costantino Ricci,Dario de Biase,Thais Maloberti et al.
Costantino Ricci et al.
Aims: Testicular adult granulosa cell tumours (AGCTs) are rare and show several clinical-pathological differences with their ovarian counterparts. In a limited number of prior studies, FOXL2 p.Cys134Trp, the hallmark mole...
Acellular mucin pools and neutrophil-to-lymphocyte ratio: unveiling hidden aggressiveness in pathological complete response after chemoradiotherapy for rectal cancer [0.03%]
细胞外黏蛋白池和中性粒细胞与淋巴细胞比率：揭开放化疗后直肠癌病理完全缓解的隐藏侵袭性特征
Zhenyu Xu,Heyuan Zhu,Xiaojie Wang et al.
Zhenyu Xu et al.
Background: Pathological complete response (pCR) following neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC) does not eliminate tumor recurrence risk, with distant metastasis remaining a criti...
Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high-frequency PIK3CA mutations revealed by molecular and immunohistochemical analysis [0.03%]
分子和免疫组化分析揭示的乳腺顶小叶癌特有的代谢重组及高频PIK3CA突变
Harumi Nakamura,Yoji Kukita,Nobuyoshi Kittaka et al.
Harumi Nakamura et al.
Aims: Apocrine carcinoma (AC) is a rare and distinct subtype of invasive breast carcinoma, typically characterized by androgen receptor (AR) positivity and negative expression of oestrogen and progesterone receptors. This...
Testicular mass frozen section examination: Pathological insights and diagnostic accuracy [0.03%]
睾丸肿物冷冻切片检查：病理学见解和诊断准确性
Roselyne Choiniere,Willem P A Boellaard,Marij Dinkelman-Smit et al.
Roselyne Choiniere et al.
Background and objectives: Testicular frozen section examination on excisional biopsy (FSEB) is an underused pathological and surgical approach, considering the increasing number of small benign testicular lesions found o...
Novel NOTCH3 alteration expanding the molecular spectrum of pericytic tumours: report of two cases [0.03%]
NOTCH3新突变扩展周细胞肿瘤分子分型报告两例
Irena Antonia Ungureanu,Megane Le Quang,Rihab Azmani et al.
Irena Antonia Ungureanu et al.
Introduction: Myofibromas are part of the pericytic tumour family, which includes myopericytomas, glomus tumours and angioleiomyomas. While they typically display benign behaviour when arising in the skin and subcutaneous...
Gabrielle Goldman-Lévy,Raymond Barnhill,Boris C Bastian et al.
Gabrielle Goldman-Lévy et al.
The 5th edition of the World Health Organization Classification of Tumours (WCT) serves as a foundation for global diagnostic standards in tumour pathology. Similar to other volumes in this series, the Skin Tumours (Skin5) edition follows a...
Daniel M Berney
Daniel M Berney
Decision-making in breast pathology reporting: the effect of clinical relevant thresholds [0.03%]
乳腺病理报告中的决策制定：临床相关阈值的影响
Zeynep E Kain,Ximena Baez-Navarro,Sabine C Linn et al.
Zeynep E Kain et al.
Aims: In breast cancer (BC) pathology reports, small differences around cut-off values can impact staging and consequently, clinical decision-making. Several pathology variables are not very exact, leaving room for interp...