Malignant epithelioid mesenchymal neoplasms with EWSR1/FUS::CREM fusions: clinicopathological and molecular genetic analysis of seven cases highlighting immunophenotypic heterogeneity, frequent aggressive behaviour, and diagnostic pitfalls [0.03%]
Ming Zhao,Jiayun Xu,Shiyu Zheng et al.
Ming Zhao et al.
Aims: Tumours harbouring FET::CREB fusions, particularly those involving EWSR1/FUS and CREM, represent an emerging group that is distinct from and unclassifiable into established categories such as angiomatoid fibrous his...
Aberrant p53 immunohistochemical staining is uncommon in serrated epithelial change, regardless of association with dysplasia [0.03%]
Dorukhan Bahceci,Gregory Y Lauwers,Won-Tak Choi
Dorukhan Bahceci
Aims: Serrated epithelial change (SEC) in inflammatory bowel disease (IBD) is most commonly defined as hyperplastic polyp-like mucosal changes lacking morphological evidence of dysplasia, identified on random or non-targe...
Richard Wing-Cheuk Wong,Karen L Talia,W Glenn McCluggage
Richard Wing-Cheuk Wong
Primary carcinomas of the vagina are uncommon tumours, accounting for
PLAG1-rearranged uterine mesenchymal tumours: A study of 11 cases showing distinct histological features beyond myxoid morphology [0.03%]
Mengyuan Cai,Ke Zuo,Lin Yu et al.
Mengyuan Cai et al.
Aims: PLAG1 gene fusions have been identified in a subset of uterine sarcomas and were historically associated with myxoid morphology. However, recent evidence shows that not all cases demonstrate myxoid features or conve...
Glomerular plasmalemma vesicle-associated protein-1 as an endothelial remodelling marker complementing C4d in chronic active antibody-mediated rejection [0.03%]
Yuto Igarashi,Mayu Shimokawa,Kunio Kawanishi et al.
Yuto Igarashi et al.
Aims: Chronic active antibody-mediated rejection (caABMR) is a major cause of late kidney allograft failure, yet reliable histological indicators of microvascular injury and therapeutic response remain insufficient. Compl...
Yu Xiong,Weiping Liu,Wenyan Zhang et al.
Yu Xiong et al.
Aims: Langerhans cell sarcoma (LCS) is a rare malignant neoplasm that relatively frequently presents with primary cutaneous involvement. Owing to its extreme rarity, it is necessary to characterize the clinicopathological...
Cecily Quinn,Puay Hoon Tan,Kimberly H Allison et al.
Cecily Quinn et al.
The 6th edition of the WHO Classification of Breast Tumours introduces both major and minor changes based on recent advances in our understanding of breast biology, developments in diagnostic modalities, identification of specific molecular...
TERT promoter-mutated thyroid carcinomas: prognostic and histologic insights according to the WHO 2022 classification [0.03%]
Seung Eun Lee,Bogyeong Han,Jung-Sun Kim et al.
Seung Eun Lee et al.
Aims: TERT promoter mutations are late molecular events associated with tumour dedifferentiation and aggressive behaviour in thyroid carcinomas (TCs). Although certain adverse histologic features, particularly tall cell m...
Understanding cholangiocarcinoma: molecular landscape, pathological classification, and challenges in biopsy diagnosis [0.03%]
Yoh Zen
Yoh Zen
Characterization of molecular features of cholangiocarcinoma (CCA) has questioned the traditional, anatomy-based classification scheme and has alternatively suggested biology-based classifications. Intrahepatic CCA has been classified into ...
Immunophenotypic assessment of pure embryonal carcinoma and yolk sac tumour suggests that reprogramming to non-seminoma occurs outside the spermatogonial niche [0.03%]
Daisy Maharjan,Květoslava Michalová,Joao Lobo et al.
Daisy Maharjan et al.
Aims: Germ cell neoplasia in situ (GCNIS) is the precursor of GCNIS-derived testicular germ cell tumours, including seminomas and non-seminomas. Most non-seminomas show mixed histology, often including components of semin...