Hybrid grading systems improve progression risk stratification in non-invasive papillary urothelial carcinoma and support a histomorphological continuum of disease progression [0.03%]
混合评分系统可改善非侵袭性乳头状尿路上皮癌的进展风险分层并支持疾病进展情况的组织病理学连续性
Jane K Nguyen,Marcello P Toscano,Jianbo Li et al.
Jane K Nguyen et al.
Objective: Histological grading is a key predictor of progression in non-muscle-invasive bladder cancer (NMIBC). The WHO 1973 three-tier system is limited by heterogeneity within the G2 category, whereas the WHO 2004/2016...
Solitary cutaneous histiocytosis: when genomics defines subclassification [0.03%]
单发性皮肤朗格汉斯细胞组织细胞增生症：当基因组学定义亚分类时
Thomas Papathomas,Markus Andreassen,Lorant Farkas et al.
Thomas Papathomas et al.
Histological assessment of treatment effect in lymph node-positive breast cancer after neoadjuvant chemotherapy [0.03%]
新辅助化疗后淋巴结阳性乳腺癌治疗效果的组织学评估
Yihong Wang,Jess Hart,Mariana Canepa et al.
Yihong Wang et al.
Aims: Neoadjuvant chemotherapy (NACT) is becoming the standard of care for lymph node (LN)-positive breast cancers. Residual disease in the breast and LN serves as a critical prognostic indicator and guides adjuvant thera...
Histopathological stratification of primary aldosteronism using the CYP11B2 size ratio: first evaluation in clinical routine [0.03%]
利用CYP11B2大小比值对原发性醛固酮增多症进行组织病理学分层：首次在临床常规中的评估
Adam Stenman,Tim Nilsson,Henrik Falhammar et al.
Adam Stenman et al.
Background: In primary aldosteronism (PA), the HISTALDO framework classifies aldosterone-producing lesions as 'classical' (solitary nodule) or 'non-classical' (multinodular or diffuse) based on CYP11B2 immunohistochemistr...
Time-dependent histopathological remodelling of the appendix in patients with ulcerative colitis [0.03%]
溃疡性结肠炎患者阑尾的时间依赖性组织病理学重塑
Kurara Yamamoto,Takanori Nishiguchi,Keiko Abe et al.
Kurara Yamamoto et al.
Aims: To characterize the endoscopic features of periappendiceal lesions and histopathological features of appendiceal lesions in patients with conventional ulcerative colitis (UC), particularly in relation to disease dur...
Nosological reappraisal of primary cutaneous apocrine carcinoma based on a clinicopathological and genetic analysis of 30 cases [0.03%]
基于临床病理和遗传分析的30例病例对原发性皮肤大汗腺癌进行疾病分类再评价
Keisuke Goto,Yoji Kukita,Shuichi Ohe et al.
Keisuke Goto et al.
Aims: The nosology of primary cutaneous apocrine carcinoma remains controversial, as the term has often been used as a heterogeneous diagnostic category. The aim of this study was to clarify the clinicopathological and mo...
Whole-slide analysis of mitotic activity in melanoma reveals higher-proliferation hotspots and distinct spatial patterns [0.03%]
全切片分析黑色素瘤的有丝分裂活性揭示了高增殖热点和不同的空间模式
Shlomo Tsuriel,Batel Gabay,Victoria Hannes et al.
Shlomo Tsuriel et al.
Introduction: Accurate assessment of mitotic activity is an important component of melanoma prognostication but remains challenging due to interobserver variability and difficulties in identifying representative mitotic h...
Long-term outcome of high-grade encapsulated papillary carcinoma of the breast: implications for staging and management [0.03%]
高分级乳腺乳头状癌的长期结局：分期和治疗方式的启示
Milena Stevanovic,Emad Rakha,Ian O Ellis et al.
Milena Stevanovic et al.
Background: Encapsulated papillary carcinoma (EPC) of the breast is an uncommon tumour with controversial biological behaviour and staging. Emerging evidence suggests that EPC with adverse pathological features (EPC-A) ma...
Thibault Kervarrec,Maxime Battistella,Nicolas Macagno
Thibault Kervarrec
Epidermal and adnexal tumours of the skin constitute a complex and heterogeneous group of neoplasms, with distinct morphology and behaviour. Over recent years, the genetic characterization of such neoplasms has enabled the identification of...
Paul W Harms
Paul W Harms
Merkel cell carcinoma (MCC) is an aggressive, poorly differentiated neuroendocrine cutaneous carcinoma that has rapidly increased in incidence over the past decades. Due to the significant risk of recurrence, metastasis and mortality, promp...