Analysis of SCLC subtype markers (ASCL1, NEUROD1, POU2F3, YAP1), DLL3, OTP, and TTF1 in 300 lung carcinoids and enteropancreatic neuroendocrine tumours [0.03%]
300例肺类癌和肠胰神经内分泌肿瘤中SCLC分型标记物（ASCL1、NEUROD1、POU2F3、YAP1）、DLL3、OTP及TTF1的分析
Jonathan Willner,Irfan Khan,Zeynep Tarcan et al.
Jonathan Willner et al.
Aims: ASCL1, NEUROD1, POU2F3 and YAP1 are recently described markers of transcriptional subtypes in small cell lung carcinoma (SCLC), while DLL3, regulated by ASCL1, is a target of novel therapeutic agents in various neur...
Genetic and immunohistochemical studies identify recurrent ACTB mutations and PTEN alterations in tubular adenomas of the breast [0.03%]
基因和免疫组化研究识别出乳腺管状腺瘤中ACTB突变和PTEN改变的复发性
Hnin Ingyin,James P Solomon,Yuewei Li et al.
Hnin Ingyin et al.
Aims: Tubular adenoma of the breast (TAB) is a rare and understudied neoplasm, initially thought to represent a fibroadenoma (FA) variant. Recently, it has been shown that TABs lack MED12 mutations indicating a distinct p...
Construction of a risk score based on the histopathological tumour microenvironment and its prognostic value in primary operable colorectal cancer [0.03%]
基于结直肠癌肿瘤微环境的预后风险评分模型的建立及其临床应用价值研究
Xiaoke Zhang,Zhengyang Wang,Liye Wang et al.
Xiaoke Zhang et al.
Aims: The incidence and mortality rates of colorectal cancer (CRC) are increasing worldwide. We aimed to construct a novel classification system, Risk Score, based on the histopathological tumour microenvironment and asse...
A minor high-grade component in non-invasive papillary urothelial carcinoma is not associated with a more indolent behaviour [0.03%]
非侵袭性乳头状尿路上皮癌中的低级别成分并不预示着更良性的行为特征
Mina S Farag,Neda Oghbaei,Jaffar Hussain et al.
Mina S Farag et al.
Aims: The latest WHO edition proposed using a cut-off of ≥5% high-grade component (%HGc) as a criterion to label non-invasive papillary urothelial carcinomas as high-grade (pTaHG). It also suggested that tumours with min...
Correct diagnosis of patients with fibrolamellar carcinoma: A Dutch nationwide study [0.03%]
荷兰全国范围内纤维板层肝癌患者正确诊断的研究
Alicia Furumaya,Abisha Gumede,Víola B Weeda et al.
Alicia Furumaya et al.
Aims: Fibrolamellar carcinoma (FLC) is a rare primary liver cancer. Adequate diagnosis is essential for appropriate treatment. The current study evaluates the diagnosis of fibrolamellar carcinoma in a Dutch cohort. ...
Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area [0.03%]
外阴皮脂腺肿瘤中人乳头瘤病毒感染和错配修复蛋白表达的关系研究
Katharina Wiedemeyer,Zainab Al-Shamma,Martin Köbel et al.
Katharina Wiedemeyer et al.
Aims: This study aimed to investigate the clinical and histopathological features of sebaceous tumours of the genital area and their association with human papilloma virus (HPV) infection and mismatch repair (MMR) protein...
Tall cell carcinoma with reversed polarity of the breast harbouring IDH1 hotspot mutation: morphologic, immunohistochemical and genetic characterization of two cases [0.03%]
形态学、免疫组化和遗传表型特征的2例IDH1热点突变伴极向逆转的高细胞癌病例报告
Gregor Krings,Sherin Hashem,Marsha A Apushkin et al.
Gregor Krings et al.
Aims: Tall cell carcinomas with reversed polarity (TCCRPs) are rare, indolent triple negative or oestrogen receptor (ER)-low positive breast cancers classically characterized by solid-papillary and papillary proliferation...
Tumour budding in pretreatment cervical biopsies: a prognosticator for personalised therapy in the era of precision oncology [0.03%]
精准肿瘤学时代个性化治疗的预后指标：术前宫颈活检中的肿瘤芽生现象
Young Sub Lee,Kwangil Yim,Chan Joo Kim et al.
Young Sub Lee et al.
Aims: Tumour budding (TB) is a noteworthy morphologic indicator for tumour microenvironment (TME) especially because it is detectable with routine haematoxylin and eosin (H&E) staining. Its prognostic relevance has been d...
GREB1-rearranged uterine tumour shares a common DNA methylation signature with ESR1-rearranged UTROSCT [0.03%]
GREB1重组型子宫肿瘤与ESR1重组型UTROSCT具有共同的DNA甲基化特征
Cheng-Han Lee,Yow-Shan Lee,Jennifer A Bennett et al.
Cheng-Han Lee et al.
Background and objectives: GREB1-rearranged uterine tumours encompass a group of uterine mesenchymal tumours with varied histologic appearances. The fusion partners to GREB1 include NCOA1-3, SS18 and NR4A3. Given that som...
Claudin-18 expression in gastric type adenocarcinoma and HPV-associated adenocarcinoma of the uterine cervix [0.03%]
Claudin-18在胃型腺癌和HPV相关宫颈腺癌中的表达
Nobuko Yasutake,Yuki Yokawa,Takehiro Tanaka et al.
Nobuko Yasutake et al.
Aims: Claudin-18 (CLDN18) is both a marker for the gastric phenotype and a therapeutic target. However, little is known about its immunoexpression in endocervical adenocarcinomas (ECAs), particularly as detected using the...